Clearance Confusion: An Exploratory Analysis of Inpatient Dosing Discordances Between Renal Estimating Equations [0.03%]
Clearance Confusion：肾功能估算公式之间的住院给药差异的探索性分析
Sean M McConachie,Laila Shammout,Dmitriy M Martirosov
Sean M McConachie
Background: Numerous equations exist for estimating renal clearance for drug dosing, and discordance rates may be as high as 40% in certain populations. However, the populations and types of equations used in these studie...
Anticoagulation Management for Impella Percutaneous Ventricular Assist Devices: An Analysis of a Single-Center Experience [0.03%]
艾抗凝法管理伊普尔拉辅助装置：单一中心经验分析
Ethan Wood,Charles Hayes,Anthony Hart
Ethan Wood
Background: Impella devices offer temporary mechanical circulatory support for cardiogenic shock. The manufacturer recommends systemic anticoagulation with a target activated clotting time of 160 to 180 s but provides no ...
Standard Versus Extended Duration Direct-Acting Antiviral Therapy in Hepatitis C Patients With Slow Response to Treatment [0.03%]
治疗丙型肝炎慢反应患者的标准化疗与延长化疗的直接抗病毒疗法比较研究
Ashley H McKnight,Mary L Townsend,Mohamed G Hashem et al.
Ashley H McKnight et al.
Background: Response-guided hepatitis C therapy was standard with interferon-based regimens but is not used for direct-acting antivirals (DAAs). Week 4 viral kinetics may predict sustained virological response (SVR) with ...
Incidence and Risk Factors of Acute Kidney Injury in Patients Receiving Concomitant Vancomycin and Continuous-Infusion Piperacillin/Tazobactam: A Retrospective Cohort Study [0.03%]
万古霉素与连续输注哌拉西林/他唑巴坦联用患者的急性肾损伤发生率及危险因素：回顾性队列研究
Kameron Blair,Elizabeth W Covington
Kameron Blair
Background: During a recent shortage of small-volume parenteral solutions, some hospitals administered piperacillin/tazobactam via continuous infusion to utilize larger fluid volumes. Although the incidence of acute kidne...
Kathleen K Adams,William L Baker,Diana M Sobieraj
Kathleen K Adams
News and social media platforms have implicated dietary supplements in the treatment and prevention of coronavirus disease 2019 (COVID-19). During this pandemic when information quickly evolves in the presence of contradicting messages and ...
Emergency Authorization of Chloroquine and Hydroxychloroquine for Treatment of COVID-19 [0.03%]
新冠肺炎疫情期间氯喹和羟氯喹的紧急授权使用政策
Christopher R Piszczatoski,Jason Powell
Christopher R Piszczatoski
The world is suffering a respiratory pandemic disease caused by a novel coronavirus (2019-nCoV), commonly known as COVID-19 (coronavirus disease 2019). The Food and Drug Administration issued an emergency authorization for chloroquine and h...
Opioid Prescribing After Discharge in a Previously Mechanically Ventilated, Opioid-Naïve Cohort [0.03%]
重症监护后机械通气新手术患者的阿片类药物出院处方
Emmeline C Academia,Christian J Gabriel,Amanda Mueller et al.
Emmeline C Academia et al.
Background: Opioids are utilized for pain management during and after mechanical ventilation in the intensive care unit (ICU). Objective: ...
Medication Regimen Complexity Index Prediction of Adverse Drug Reaction-Related Hospital Admissions [0.03%]
用药复杂性指数预测药物不良反应相关的住院风险
Colin M Curtain,Jie Yi Chang,Justin Cousins et al.
Colin M Curtain et al.
Background: The relationship between the medication regimen complexity index (MRCI) and adverse drug reaction (ADR)-related hospital admissions has not yet specifically been investigated. ...
Desirae E Lindquist,Laura B Poveromo,Lisa M Vann et al.
Desirae E Lindquist et al.
Disparities in the Use of Guideline-Based Pharmacotherapy Exist for Atherosclerotic Cardiovascular Disease and Heart Failure Patients Who Have Intellectual/Developmental Disabilities in a Commercially Insured Database [0.03%]
在商业保险数据库中动脉粥样硬化性心血管疾病和心力衰竭患者使用基于指南的药物治疗存在智力/发育障碍差异
Steven R Erickson,Tanima Basu,Michael P Dorsch et al.
Steven R Erickson et al.
Background: Patients who have intellectual/developmental disabilities (IDDs) develop atherosclerotic cardiovascular disease (ASCVD) or heart failure (HF) at rates similar to or higher than the general population. They als...