Evaluating the Role of Erythrocyte-Related Markers in Predicting Adenosine Response in Supraventricular Tachycardia [0.03%]
评估红细胞相关标志物在预测房性心动过速腺苷反应中的作用
Seth Carroll,Kathleen Soter,Mallory McGee et al.
Seth Carroll et al.
Background: Supraventricular tachycardia (SVT) accounts for ~50 000 emergency department (ED) visits annually. Adenosine is a commonly used pharmacologic intervention, but predictors of success remain unclear. Erythrocyte...
Safety and Efficacy of the Prescribing Practices of Ketamine for Pain and Agitation in the Medical Intensive Care Unit [0.03%]
重症监护病房中使用氯胺酮止痛和镇静的处方安全性和有效性
Shaelyn Cooper,MaryEllen Antkowiak,Derek Devine et al.
Shaelyn Cooper et al.
Background: Ketamine has analgesic and sedative properties that are thought to reduce opioid tolerance and opioid-induced hyperalgesia. For this reason, ketamine may be used to manage pain and agitation, although the lite...
Comparing Vasopressin and Hydrocortisone as Adjunctive Measures in Septic Shock [0.03%]
血管加压素与氢化可的松作为难治性感染性休克辅助治疗的比较研究
Hannah F Wang,Beena Cheriyan,Marianne Huebner et al.
Hannah F Wang et al.
Background: Norepinephrine has been widely established as the first-line agent for hemodynamic support in septic shock. The timing and order of initiation of vasopressin and hydrocortisone as adjunctive agents remains hig...
Garadacimab-gxii-A Novel Prophylactic Treatment for Hereditary Angioedema: A Drug Review [0.03%]
gardacimab-gxii：遗传性血管性水肿的新型预防治疗药物：药物评价
Kelli M Schindel,Omar Raheel,Chenan A Huang et al.
Kelli M Schindel et al.
Objective: To describe garadacimab-gxii, an antibody that inhibits factor XII, indicated for hereditary angioedema (HAE) prophylaxis, approved by the Food and Drug Administration in June 2025 for patients 12 years and old...
Effect of Sphingosine-1-Phosphate Receptor Modulators on Insulin Resistance: A Review [0.03%]
鞘氨醇-1-磷酸受体调节剂对胰岛素抵抗的影响：综述研究
Sandra Caíña López,Luciano Martínez Martínez,Andrea Bartolomé Figueroa et al.
Sandra Caíña López et al.
Objective: The objective is to review the potential impact of sphingosine-1-phosphate (S1P) receptor modulators on insulin resistance in patients with multiple sclerosis, including underlying mechanisms and clinical evide...
Transdermal "Natural GLP-1" Dietary Supplements Violate Law and Place Patients at Risk [0.03%]
违规的经皮“天然GLP-1”膳食补充剂令患者处于危险之中
C Michael White,Zeeya Tai,Klaus Nuzi
C Michael White
Consumers precluded from obtaining semaglutide or tirzepatide by clinicians or insurers are turning to natural "GLP-1" transdermal patches. The Dietary Supplement Health and Education Act specifies dietary supplement products must be swallo...
Evaluation and Optimization of INR Goals in Patients With Mechanical Aortic Valves in a Pharmacist-Run Clinic: An Anticoagulation Stewardship Initiative [0.03%]
药师管理的心脏病诊所中机械瓣膜患者INR目标值的评估与优化：一项抗凝 stewardship 项目
Barbara Wang,Madison Hubert,Malgorzata Symons et al.
Barbara Wang et al.
Background: Patients with a mechanical aortic valve replacement (AVR) require lifelong anticoagulation with warfarin. International normalized ratio (INR) goals for mechanical AVRs can change throughout treatment as risk ...
Estimating GFR Using Creatinine, Cystatin C, or Both and the Impact on Predicted Vancomycin Half-Life [0.03%]
基于血清肌酐、胱抑素C或联合估算肾小球滤过率对预测万古霉素半衰期的影响
Amanda Dobson,Robert MacLaren,Shelby Pons et al.
Amanda Dobson et al.
Background: Glomerular filtration rate (GFR) is commonly estimated with equations using creatinine, cystatin C, or a combination of both. Drug dosages may differ depending on the which equation. ...
Fitusiran: A Novel Antithrombin-Targeting Therapy for Hemophilia A and B, With or Without Inhibitors [0.03%]
Fitusiran：一种新型抗凝血酶疗法用于甲型和乙型血友病患者（有或无抑制物）
Mohammad T Alashqar,Milap C Nahata
Mohammad T Alashqar
Objective: The objective of the study is to critically review the literature about clinical evidence on the efficacy and safety of fitusiran among patients with hemophilia A or B. ...
Gabapentinoids in Chronic Kidney Disease: A Closer Look at Respiratory Risk [0.03%]
慢性肾病患者的加巴喷丁类药物治疗：仔细评估呼吸系统风险
Lauren Harven,Renee Alexander Paxton,Christopher Giuliano
Lauren Harven
Background: In 2019, the Food and Drug Administration issued a warning regarding the risk of respiratory depression with gabapentin use, especially when combined with opioids or other central nervous system depressants. W...