Caroline R Champion
Caroline R Champion
Objective: To review the immunogenicity and safety of a hepatitis B vaccine containing the cytosine phosphoguanosine (CpG) 1018 adjuvant (HepB-CpG). Data ...
The Association of ICH Exclusion Criteria With Mortality and Disability Rates in ICH Patients Receiving 4F-PCC for Anticoagulation Reversal [0.03%]
接受4F-PCC抗凝逆转的ICH患者中ICH排除标准与死亡率和残疾率的关系
Maryam Zaeem,Blake A Porter,Samantha Delibert et al.
Maryam Zaeem et al.
Background: Intracranial hemorrhage (ICH) exclusion criteria in the landmark four-factor prothrombin complex concentrate (4F-PCC) trial have not been incorporated into clinical practice and incremental predictive ability ...
Fostemsavir: A Novel Attachment Inhibitor for Patients With Multidrug-Resistant HIV-1 Infection [0.03%]
福斯特韦尔：一种新型的用于多重药物抵抗HIV-1感染患者的附着抑制剂
Kayla Hiryak,David E Koren
Kayla Hiryak
Objective: To review the efficacy and safety of fostemsavir (FTR) for the treatment of multidrug-resistant HIV-1 infection in heavily treatment-experienced adults who are failing their current antiretroviral regimen. ...
Effectiveness of a Calculation-Free Weight-Based Unfractionated Heparin Nomogram With Anti-Xa Level Monitoring Compared With Activated Partial Thromboplastin Time [0.03%]
无计算体重为基础的普通肝素 nomogram 联合抗 -Xa 水平监测与活化部分凝血活酶时间比较的有效性研究
Nicole M Kindelin,Ananth M Anthes,Sarah M Providence et al.
Nicole M Kindelin et al.
Background: Accurate monitoring of intravenous unfractionated heparin (UFH) is essential to mitigate the risk of adverse drug events associated with dosing errors. Although recent data support anti-factor Xa (anti-Xa) mon...
Comparative Study
The Annals of pharmacotherapy. 2021 May;55(5):575-583. DOI:10.1177/1060028020961503 2021
Performance Assessment of a Multifaceted Unfractionated Heparin Dosing Protocol in Adult Patients on Extracorporeal Membrane Oxygenator [0.03%]
成人膜肺氧合患者多因素肝素给药方案的疗效评估
Abdulrazaq Al-Jazairi,Shahad Raslan,Rayd Al-Mehizia et al.
Abdulrazaq Al-Jazairi et al.
Background: The use of extracorporeal membrane oxygenator (ECMO) support devices are associated with complications, including bleeding and thrombosis. Unfractionated heparin (UFH) is the gold standard anticoagulant in ECM...
Evaluation of Acute Postoperative Pain Management During an Injectable Opioid Shortage [0.03%]
注射用阿片类药物短缺期间急性术后疼痛管理的评估
Kenneth K Tran,Madeline A VanDaele,Sylvia Tran et al.
Kenneth K Tran et al.
Background: Drug product shortages, including injectable opioids, are common and have the potential to adversely affect patient care. Objective: ...
Observational Study
The Annals of pharmacotherapy. 2021 May;55(5):611-617. DOI:10.1177/1060028020962037 2021
Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma [0.03%]
恩福妥单抗-ejfv：首款针对尿路上皮癌的靶向NECTIN4抗体药物偶联物
Zachery Halford,Mary Kate Anderson,Matthew D Clark
Zachery Halford
Objective: To evaluate the pharmacology, pharmacokinetics, clinical efficacy, safety, dosing, cost, and clinical implications of enfortumab vedotin-ejfv (EV) in the treatment of locally advanced or metastatic urothelial c...
Direct Oral Anticoagulant for the Treatment of VTE in Cancer Patients: A Systematic Review and Meta-analysis [0.03%]
直接口服抗凝剂治疗癌症患者的VTE的系统评价和荟萃分析
Shujie Dong,Yatong Zhang,Yan Li et al.
Shujie Dong et al.
Background: Recent clinical guidelines suggest direct oral anticoagulants (DOACs) as treatment for cancer-associated thrombosis (CAT), but the strength of such recommendations was not clear. Newly released trials add unce...
Development of Machine Learning Models to Validate a Medication Regimen Complexity Scoring Tool for Critically Ill Patients [0.03%]
开发机器学习模型以验证危重病人药物治疗方案复杂性评分工具的有效性
Mohammad A Al-Mamun,Todd Brothers,Andrea Sikora Newsome
Mohammad A Al-Mamun
Introduction: The Medication Regimen Complexity -Intensive Care Unit (MRC-ICU) is the first tool for measuring medication regimen complexity in critically ill patients. This study tested machine learning (ML) models to in...
Observational Study
The Annals of pharmacotherapy. 2021 Apr;55(4):421-429. DOI:10.1177/1060028020959042 2021
Initial Dosage Optimization of Tacrolimus in Pediatric Patients With Thalassemia Major Undergoing Hematopoietic Stem Cell Transplantation Based on Population Pharmacokinetics [0.03%]
基于群体药代动力学的地塞米松初始剂量优化研究：用于接受造血干细胞移植治疗的海洋性贫血 major 儿童患者
Siru Zhou,Ren Zhang,Chunle Lv et al.
Siru Zhou et al.
Background: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for hematological disorders. Tacrolimus is widely used after HSCT, but it has highly interindividual variable pharmacokinetics. Populati...