Adonice P Khoury,Jason Powell
Adonice P Khoury
Objective: To review the published data including the pharmacology, efficacy, and safety of seladelpar, a peroxisome proliferator-activated receptor delta (PPARδ) agonist leading to the Food and Drug Administration (FDA)...
Severe Acute Respiratory Failure Associated With Trimethoprim/Sulfamethoxazole Among Adolescent and Young Adults: An Active Comparator-Restricted Disproportionality Analysis From the FDA Adverse Event Reporting System (FAERS) Database [0.03%]
FDA不良事件报告系统数据库中有关青少年和年轻成年人的复方新诺明所致急性呼吸衰竭严重病例分析
Fatemeh Ahmadi,Niaz Chalabianloo,Eric McArthur et al.
Fatemeh Ahmadi et al.
Background: The US Food and Drug Administration (FDA) has raised concerns about a potential link between trimethoprim/sulfamethoxazole (TMP-SMX) and an increased risk of acute respiratory failure/acute respiratory distres...
Retrospective Analysis of Tacrolimus Levels: The First 56 Days Following Allogeneic Hematopoietic Stem Cell Transplant and Patient Outcomes [0.03%]
回顾性分析他克莫司水平：异基因造血干细胞移植后前56天及患者结局
Kateryna Kovalenko,Joseph Bubalo,Jennifer Saultz et al.
Kateryna Kovalenko et al.
Background: Despite prophylaxis, acute graft-versus-host disease (aGVHD) occurs in up to 40% to 60% of patients undergoing an allogeneic hematopoietic stem cell transplantation (alloHSCT). Tacrolimus remains a common GVHD...
A Randomized Controlled Trial Plus a Systematic Review and Meta-Analysis of Published Studies Evaluating a Conventional Prophylactic Regimen of Oral Dexamethasone vs Short-Course Intravenous Dexamethasone in Preventing Paclitaxel-Associated Hypersensitivity Reactions in Patients With Gynecologic Malignancies [0.03%]
一项随机对照试验加上对已发表研究的系统评价和荟萃分析评估口服地塞米松常规预防方案与短程静脉注射地塞米松在预防妇科恶性肿瘤患者紫杉醇相关超敏反应中的效果
Kofi N Donkor,Hyeree Jang,Julie Hana Selim et al.
Kofi N Donkor et al.
Background: Hypersensitivity reactions (HSRs) are often encountered in patients receiving paclitaxel infusions. The conventional method, comprising dexamethasone 20 mg (Dex20) taken 12 and 6 hours before paclitaxel plus h...
Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Nervous System Disorders: A Systematic Review and Meta-Analysis [0.03%]
钠-葡萄糖共转运蛋白2抑制剂对神经系统疾病的效应：系统性评价和荟萃分析
Bo Xu,Mingxia Yang,Shaoqian Li et al.
Bo Xu et al.
Background: Adults with type 2 diabetes mellitus (T2DM) are at an increased risk for certain brain or psychiatric disorders, as are those with or without chronic kidney disease or heart failure. Whether sodium-glucose cot...
Adverse Reactions by Radiopharmaceuticals: Retrospective Analysis of the Portuguese National Pharmacovigilance System [0.03%]
放射药物的不良反应：葡萄牙国家药物警戒系统的回顾性分析
Sara Martins,Ângelo Jesus,Ricardo Andrade et al.
Sara Martins et al.
Background: Radiopharmaceuticals are essential in the field of nuclear medicine, but like any other medicinal product, radiopharmaceuticals can potentially cause adverse reactions in patients. ...
A Comparison of Outcomes of Standard Weight-Based and Capped Doses of Albumin for Spontaneous Bacterial Peritonitis [0.03%]
标准体重依赖型与固定剂量人血白蛋白治疗自发性细菌性腹膜炎的比较研究
Lily Huang,Avery Marcotte,Taryn S Murray et al.
Lily Huang et al.
Background: Albumin is recommended in the management of patients with spontaneous bacterial peritonitis (SBP) to reduce rates of renal injury and mortality. Current guideline recommendations suggest an intravenous albumin...
Nitrofurantoin Versus Comparators in the Treatment of Cystitis due to Extended-Spectrum β-Lactamase-Producing Enterobacterales: A Multicenter Cohort Study [0.03%]
治疗由于可产生超广谱β内酰胺酶的肠杆菌科引起的膀胱炎中呋喃妥因与其他药物的对比：多中心队列研究
Abrar K Thabit,Khalid Al Sulaiman,Lulwa Alfaraj et al.
Abrar K Thabit et al.
Background: The increasing prevalence of extended-spectrum β-lactamase (ESBL)-producing bacteria has limited treatment options for cystitis. The recommendation of nitrofurantoin for treatment is based solely on in vitro ...
Impact of Hypoalbuminemia on Clinical Outcomes in Patients Receiving Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia [0.03%]
低白蛋白血症对接受复方新诺明治疗的耐甲氧西林金黄色葡萄球菌所致血流感染患者的临床结局的影响
Kaylee M Whitenack,Dan Ilges,Kevin L Epps et al.
Kaylee M Whitenack et al.
Background: Cefazolin is a preferred treatment option for methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. Recent studies have suggested a potential impact on clinical outcomes in patients with hypoalbumin...
Safety of Different Weight-Based Dosing Strategies of Intravenous Acyclovir in Obese Patients: A Retrospective Cohort Study [0.03%]
肥胖患者静脉注射阿昔洛韦不同体重给药方案的安全性：一项回顾队列研究
Mohamed Omar Saad,Safeya Omar Habib,Ahmed Mohammed Alhomosy et al.
Mohamed Omar Saad et al.
Background: In obese patients receiving intravenous (IV) acyclovir, conflicting data exist regarding the risk of acute kidney injury (AKI) with different weight-based dosing strategies: total body weight (TBW), adjusted b...