Mechanosensitive ion channels in immunity from biophysics to mechanomedicine [0.03%]
从生物物理学到机械医疗的免疫系统中的机械敏感性离子通道
Hangyu Zhang,Dexiang Jiang,Yimin Mou et al.
Hangyu Zhang et al.
Immune cells operate within a dynamic mechanical environment. Shear stress, matrix stiffness, membrane tension, and cellular traction continuously shape their fate and function. Mechanosensitive ion channels (MSICs) are the convergent molec...
Meso-soup: A Community Approach to Building a Computational Description of the Biological Mesoscale [0.03%]
介观汤：建立生物介观尺度计算描述的社区方法
Sarah Anne Harris,Gianluca Lattanzi,Angelo Rosa et al.
Sarah Anne Harris et al.
Physics-based models of biomolecular systems that explicitly represent biomolecular structure and mechanics, such as atomistic molecular dynamics simulations are well-established because experimental data has been available to iteratively i...
Electrostatics and disease: A large-scale assessment of human missense variants causing protein charge alterations and their implications for disease [0.03%]
静电与疾病：人类错义变异导致的蛋白质电荷变化的大规模评估及其对疾病的含义
Nirav Modha,Shailesh Kumar Panday,Emil Alexov
Nirav Modha
How do changes in electrical charge drive protein dysfunction and result in pathogenicity? This study investigates the relationship between charge-altering missense mutations and pathogenicity across a large-scale dataset, the MOGEDO databa...
Charge reversal in the heparin-binding pocket enhances the stability and activity of the human FGF1 [0.03%]
将肝素结合口袋中的电荷反转可增强人成纤维细胞生长因子FGF1的稳定性和活性
Julie Eberle Davis,Rebecca Kerr,Jeevapani J Hettige et al.
Julie Eberle Davis et al.
Human fibroblast growth factor 1 (hFGF1) is a potent signaling molecule whose role in cell growth, differentiation, and migration has made it an excellent candidate for wide-ranging biomedical applications. hFGF1 binds heparan sulfate prote...
Cell-size heterogeneity acts as a regime-dependent mechanical switch for collective migration [0.03%]
细胞大小异质性作为集体迁移的制度依赖性机械开关的作用
Xiangdong Kong,Xinyuan Wu,Mingyue Wang et al.
Xiangdong Kong et al.
Cell-size heterogeneity is ubiquitous in epithelial tissues, yet the fundamental physical principles governing its impact on collective migration remain elusive. Here, we show that size heterogeneity acts as a regime-dependent mechanical sw...
Conformational Bifurcation of Tau R3-R4 Oligomers Underlies Fibril Polymorphism [0.03%]
Tau R3-R4 寡聚体构象分歧造就原纤维多样性
Tong Zhang,Lingling Dai,Yanping Ma et al.
Tong Zhang et al.
Tau aggregation into amyloid fibrils is a central pathological feature of multiple neurodegenerative diseases, yet identical tau sequences can adopt structurally distinct fibril conformations associated with different disorders. How such di...
Dynamical-nonequilibrium (D-NEMD) alanine scanning for identifying allosteric positions in proteins [0.03%]
动态非平衡(D-NEMD)型丙氨酸扫描法在蛋白质中识别别构位点的应用
Balazs Balega,Michael Beer,Dan T S Pike et al.
Balazs Balega et al.
Allosteric effects are widespread in proteins, but predicting the impact of sequence substitutions at positions distant from ligand-binding or enzyme active sites remains challenging, as their effects are mediated through complex dynamical ...
Chain Collapse, Reduced Dielectric, and Water Release Drive Protein Phase Separation [0.03%]
链崩解、介电常数降低和水分释放驱动蛋白质相分离
Ethan A Perets,Jacob A Spies,Justin H Cheong et al.
Ethan A Perets et al.
Biomolecular condensates represent unique microenvironments that organize intracellular biology and promote biochemical reactions. However, the biomolecular interactions driving condensate phase separation are often weak, transient, and het...
Multi-body Fluctuation-Induced Forces Between Membrane Proteins: Insights from Mesoscale Simulations [0.03%]
膜蛋白之间的多体涨落诱导力：来自介观模拟的见解
Adrià Bravo Vidal,Weria Pezeshkian
Adrià Bravo Vidal
The spatial organization of membrane-associated proteins is essential for a wide range of cellular processes, including signal transduction, endocytosis, and cell adhesion. While protein clustering can be driven by direct short-range forces...
Mapping Active-Site Conformational Ensembles Along Competing Catalytic Pathways of the Hairpin Ribozyme [0.03%]
发夹型核酶催化路径竞争过程中的活性中心构象族变化规律映射图
Sélène Forget,Guillaume Stirnemann
Sélène Forget
The catalytic mechanism of the hairpin ribozyme has remained controversial for more than two decades, with different experimental approaches often supporting distinct mechanistic interpretations. In this work, we investigate the conformatio...