Metabolic Vulnerability Indices and Alzheimer's Disease Risk: A Prospective Analysis of the UK Biobank Cohort [0.03%]
代谢脆弱性指标与阿尔茨海默病风险的关系：英国生物银行队列的前瞻性分析
Guanran Ding,Yuting Liu,Yixin Zhao et al.
Guanran Ding et al.
Background: Metabolic dysfunction is implicated in Alzheimer's disease (AD) pathogenesis. Branched-chain amino acids (BCAAs) have been prospectively linked to dementia risk, yet prospective associations of composite metab...
Insulin resistance mediates associations of weight gain with serum uric acid and hyperuricemia in Chinese population [0.03%]
胰岛素抵抗介导了体重增加与血尿酸及高尿酸血症的关联：一项中国人群研究
Shanshan Huang,Junxin Wen,Qingxin Qin et al.
Shanshan Huang et al.
Background: Studies on the association between weight change and serum uric acid (SUA) or hyperuricemia (HUA) remain limited, and the underlying mechanisms remain unclear. ...
Later energy intake within a shorter eating window is associated with adverse metabolic profiles among Korean adults [0.03%]
在韩国成年人群中，较短进食时间段内的后一阶段能量摄入与代谢异常有关
Hannah Kim,Hyojee Joung,Sangah Shin
Hannah Kim
Background: Mistimed eating has been implicated in adverse metabolic outcomes, including obesity and metabolic syndrome. However, existing studies have largely examined isolated aspects of time-related eating behaviors. ...
Long-term exposure to food-contact microplastics disrupts gut microbiota and alters colon metabolites [0.03%]
长期接触食物接触微塑料会扰乱肠道微生物群并改变结肠代谢物
Shihong Su,Fangfang Yan
Shihong Su
Microplastics (MPs) are increasingly recognized as widespread contaminants, and the impact of long-term exposure to different types of MPs on colon damage is poorly explored. The effects of four food-contact MPs (polyethylene (PE), polyprop...
Intake of herring oils resulted in lower pulmonary concentration of angiotensin-converting enzyme 2 but did not affect blood pressure in male obese Zucker fa/fa rats [0.03%]
食用鲱鱼油可降低肥胖 Zucker 雄性大鼠肺组织中血管紧张素转换酶 2 的浓度但不影响血压
Andrea Hansen,Svein Are Mjøs,Eirik Søfteland et al.
Andrea Hansen et al.
Background: Angiotensin-converting enzyme 2 (ACE2) is a receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is involved in blood pressure regulation and inflammation through the renin-angiote...
Persistent lipotoxicity overwhelms adaptive capacity in human hepatic cell line [0.03%]
人肝细胞系中的持续脂毒性超越了适应能力
Ilaria Serra,Elisa Bisconti,Francesco Vari et al.
Ilaria Serra et al.
Background: Chronic fatty acid (FA) elevation drives metabolic dysfunction-associated liver disease (MASLD). Hepatocytes buffer transient lipid overload via coordinated adaptive mechanisms, but the temporal limits of this...
Metabolic, endocrine and appetite responses to carbohydrate versus niacin ingestion during exercise in healthy females and males [0.03%]
健康男女在运动中摄入碳水化合物和烟酸对代谢、内分泌及摄食反应的影响
Louise Bradshaw,Alfonso Moreno-Cabañas,Bruno Spellanzon et al.
Louise Bradshaw et al.
Background: The substrates used during exercise may influence the post-exercise response of systemic metabolites and hormones, along with the drive to refeed following exercise. However, no study has assessed whether mani...
Psychological attributes predict dietary pattern transitions in older adults: Evidence from a national longitudinal study on healthy aging [0.03%]
心理特征预测老年人饮食模式的转变——来自一项全国性健康老龄化纵向研究的证据
Cheng-Cheng Niu,Cody Ding,Yue-Qin Hu et al.
Cheng-Cheng Niu et al.
Background: Dietary patterns are important determinants of health in older adults, yet little is known about how psychological attributes influence changes in dietary patterns over time. ...
Fish and Shellfish Consumption by Type and Risks of All-Cause and Cause-Specific Mortality in the Japan Public Health Centre-Based Prospective Study [0.03%]
日本公共卫生中心前瞻性研究中按鱼类和贝类的类型分类的摄入量与全因及特定原因死亡率之间的关系
Mio Fujimaki,Junko Ishihara,Rieko Kanehara et al.
Mio Fujimaki et al.
Background: Although numerous studies have separately examined the fish and shellfish intakes, fish types, and n-3 polyunsaturated fatty acids (n-3 PUFAs) in relation to mortality, few studies have concurrently evaluated ...
Long-term supplementation with fruits and vegetables prevents cognitive impairment induced by a Western-style high-fat diet in male mice [0.03%]
长期摄入果蔬能够预防西方高脂饮食诱导的小鼠认知障碍
Weimin Guo,Barbara Shukitt-Hale,Dayong Wu et al.
Weimin Guo et al.
Background: Aging, obesity, and high-fat Western diets are linked to increased risk of cognitive decline. Although higher fruit and vegetable (FV) intake may protect against cognitive decline, evidence remains inconsisten...