Elia D Tait Wojno
Elia D Tait Wojno
Drurey et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211140) show that excretory/secretory products from the parasitic helminth Heligmosomoides polygyrus suppress the host-protective small intestinal epithelial response. These fin...
Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C [0.03%]
3K3A活化蛋白C对小鼠缺血性白质和少突胶质细胞的保护作用
Mikko T Huuskonen,Yaoming Wang,Angeliki Maria Nikolakopoulou et al.
Mikko T Huuskonen et al.
Subcortical white matter (WM) stroke accounts for 25% of all strokes and is the second leading cause of dementia. Despite such clinical importance, we still do not have an effective treatment for ischemic WM stroke, and the mechanisms of WM...
A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15 [0.03%]
表达生长因子的巨噬细胞亚群通过GDF-15调控再生性炎症反应
Andreas Patsalos,Laszlo Halasz,Miguel A Medina-Serpas et al.
Andreas Patsalos et al.
Muscle regeneration is the result of the concerted action of multiple cell types driven by the temporarily controlled phenotype switches of infiltrating monocyte-derived macrophages. Pro-inflammatory macrophages transition into a phenotype ...
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway [0.03%]
WEE1抑制通过激活ERV和dsRNA途径诱导抗肿瘤免疫
Ensong Guo,Rourou Xiao,Yifan Wu et al.
Ensong Guo et al.
Targeted therapies represent attractive combination partners with immune checkpoint blockade (ICB) to increase the population of patients who benefit or to interdict the emergence of resistance. We demonstrate that targeting WEE1 up-regulat...
DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis [0.03%]
DCIR及其配体去唾液酸双天线N-糖链对DC功能和破骨细胞生成的调节作用
Tomonori Kaifu,Rikio Yabe,Takumi Maruhashi et al.
Tomonori Kaifu et al.
Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor with a carbohydrate recognition domain and an immunoreceptor tyrosine-based inhibitory motif. Previously, we showed that Dcir-/- mice spontaneously develop autoimmune enthesit...
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation [0.03%]
血干细胞的PU.1上调是分化没有快速自调节的结果
Nouraiz Ahmed,Martin Etzrodt,Philip Dettinger et al.
Nouraiz Ahmed et al.
Transcription factors (TFs) regulate cell fates, and their expression must be tightly regulated. Autoregulation is assumed to regulate many TFs' own expression to control cell fates. Here, we manipulate and quantify the (auto)regulation of ...
ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice [0.03%]
ACC1表达的致病T辅助2细胞群促进小鼠肺部和皮肤炎症
Takahiro Nakajima,Toshio Kanno,Satoru Yokoyama et al.
Takahiro Nakajima et al.
T cells possess distinguishing effector functions and drive inflammatory disorders. We have previously identified IL-5-producing Th2 cells as the pathogenic population predominantly involved in the pathology of allergic inflammation. Howeve...
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy [0.03%]
NR2F1特异性激动剂通过诱导癌细胞休眠来抑制转移
Bassem D Khalil,Roberto Sanchez,Tasrina Rahman et al.
Bassem D Khalil et al.
We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically activates dormancy programs in malignant cells. The agonist led to a self-regulated increase in NR2F1 mRNA and protein and downstream transcription of a...
Roland A Cooper,Laura Kirkman
Roland A Cooper
Innovative drug treatments for malaria, optimally with novel targets, are needed to combat the threat of parasite drug resistance. As drug development efforts continue, there may be a role for a host-targeting, repurposed cancer drug admini...
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients [0.03%]
高OXPHOS的CD8 T细胞亚群可预测黑色素瘤患者对免疫治疗具有抗性
Chuan Li,Yee Peng Phoon,Keaton Karlinsey et al.
Chuan Li et al.
Immune checkpoint inhibitor (ICI) therapy continues to revolutionize melanoma treatment, but only a subset of patients respond. Major efforts are underway to develop minimally invasive predictive assays of ICI response. Using single-cell tr...