Stephen L Nutt,Julie Tellier
Stephen L Nutt
The generation of high-affinity antibodies in the germinal center (GC) requires interplay between GC B cells and T follicular helper cells. Rauschmeier et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211406) report that Bhlhe40 rest...
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion [0.03%]
TCR信号强度界定了T细胞功能障碍和癌症逃逸的不同机制
Mojdeh Shakiba,Paul Zumbo,Gabriel Espinosa-Carrasco et al.
Mojdeh Shakiba et al.
T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor antigens with varying TCR signal strength. High-signal-strengt...
Michael H Atkins,Rebecca Scarfò,Kathleen E McGrath et al.
Michael H Atkins et al.
In the mouse, the first hematopoietic cells are generated in the yolk sac from the primitive, erythro-myeloid progenitor (EMP) and lymphoid programs that are specified before the emergence of hematopoietic stem cells. While many of the yolk...
Yousuke Takahama
Yousuke Takahama
Whether autologous hematopoietic stem cell transplantation is free from graft-versus-host disease is controversial. Alawam et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211239) now demonstrate that prolonged damage in thymic medul...
Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis [0.03%]
Bhlhe40通过抑制生发中心反应预防淋巴瘤发生的作用机制研究
René Rauschmeier,Annika Reinhardt,Charlotte Gustafsson et al.
René Rauschmeier et al.
The generation of high-affinity antibodies against pathogens and vaccines requires the germinal center (GC) reaction, which relies on a complex interplay between specialized effector B and CD4 T lymphocytes, the GC B cells and T follicular ...
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer [0.03%]
前列腺癌中的脂质载负肿瘤相关巨噬细胞可促进肿瘤生长和侵袭性
Michela Masetti,Roberta Carriero,Federica Portale et al.
Michela Masetti et al.
Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis of this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell R...
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis [0.03%]
抑制ADAM17可抑制内皮细胞坏死性凋亡并阻止转移
Julia Bolik,Freia Krause,Marija Stevanovic et al.
Julia Bolik et al.
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of blood vessels to escape the hostile circulation and establish metastases at distant organ sites. Here, we id...
TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C [0.03%]
TIM3+ TRBV11-2 T细胞和IFNγ信号在巡逻单核细胞和CD16+自然杀伤细胞中界定了MIS-C
Levi Hoste,Lisa Roels,Leslie Naesens et al.
Levi Hoste et al.
In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation syndrome termed multisystem inflammatory syndrome in children (MIS-C). We compared MIS-C immunopathology with severe COVID-19 in adults. MIS-C does not...
Danielle J Dauphars,Ariana Mihai,Liuyang Wang et al.
Danielle J Dauphars et al.
The Tcra repertoire is generated by multiple rounds of Vα-Jα rearrangement. However, Tcrd recombination precedes Tcra recombination within the complex Tcra-Tcrd locus. Here, by ablating Tcrd recombination, we report that Tcrd rearrangemen...
B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice [0.03%]
TBK1从B细胞本身分泌对小鼠感染和接种疫苗期间生发中心的形成至关重要
Michelle S J Lee,Takeshi Inoue,Wataru Ise et al.
Michelle S J Lee et al.
The germinal center (GC) is a site where somatic hypermutation and clonal selection are coupled for antibody affinity maturation against infections. However, how GCs are formed and regulated is incompletely understood. Here, we identified a...