Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells [0.03%]
Bcl6和Blimp1的依赖性驱动小鼠记忆和滤泡辅助CD4 + T细胞的分化不同
Thomas Ciucci,Melanie S Vacchio,Ting Chen et al.
Thomas Ciucci et al.
During the immune response, CD4+ T cells differentiate into distinct effector subtypes, including follicular helper T (Tfh) cells that help B cells, and into memory cells. Tfh and memory cells are required for long-term immunity; both depen...
Making memories with Bcl-6 [0.03%]
Bcl-6形成的记忆
Kaitlin A Read,Kenneth J Oestreich
Kaitlin A Read
For over a decade, mutual antagonism between the transcriptional repressors Bcl-6 and Blimp-1 has been appreciated as a key mechanistic determinant of lymphoid differentiation programs. Now, in this issue of JEM, Ciucci et al. (2021. J. Exp...
Li Wang,Michael A Crackower,Hao Wu
Li Wang
Inflammasome proteins play an important role in many diseases of high unmet need, making them attractive drug targets. However, drug discovery for inflammasome proteins has been challenging in part due to the difficulty in solving high-reso...
Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products [0.03%]
肠道上皮簇细胞的诱导被小鼠蠕虫及其分泌物所抵消
Claire Drurey,Håvard T Lindholm,Gillian Coakley et al.
Claire Drurey et al.
Helminth parasites are adept manipulators of the immune system, using multiple strategies to evade the host type 2 response. In the intestinal niche, the epithelium is crucial for initiating type 2 immunity via tuft cells, which together wi...
Clifton E Barry,Katrin D Mayer-Barber
Clifton E Barry
The majority of humans infected with Mycobacterium tuberculosis never experience clinical symptoms or signs, but predicting those who will remains out of reach. Here, we discuss recent studies that reveal patterns and pathways that determin...
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons [0.03%]
ZNF382通过抑制DRG神经元中Cxcl13的silencer介导的表观遗传活性来控制小鼠神经病理性疼痛
Longfei Ma,Lina Yu,Bao-Chun Jiang et al.
Longfei Ma et al.
Nerve injury-induced changes of gene expression in dorsal root ganglion (DRG) are critical for neuropathic pain genesis. However, how these changes occur remains elusive. Here we report the down-regulation of zinc finger protein 382 (ZNF382...
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice [0.03%]
茎环RNA活化剂可保护小鼠免受急性及慢性SARS-CoV-2感染
Tianyang Mao,Benjamin Israelow,Carolina Lucas et al.
Tianyang Mao et al.
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I agonist, stem-loop RNA ...
Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation [0.03%]
中性粒细胞DREAM促进血管炎症中的中性粒细胞募集
Jing Li,Tripti Kumari,Andrew Barazia et al.
Jing Li et al.
The interaction between neutrophils and endothelial cells is critical for the pathogenesis of vascular inflammation. However, the regulation of neutrophil adhesive function remains not fully understood. Intravital microscopy demonstrates th...
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis [0.03%]
儿童肠道病毒菱脑炎中TLR3或MDA5依赖的I型IFN免疫的先天性错误
Jie Chen,Huie Jing,Andrea Martin-Nalda et al.
Jie Chen et al.
Enterovirus (EV) infection rarely results in life-threatening infection of the central nervous system. We report two unrelated children with EV30 and EV71 rhombencephalitis. One patient carries compound heterozygous TLR3 variants (loss-of-f...
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development [0.03%]
组蛋白去甲基化酶Lsd1在T细胞发育过程中调控多重重塑基因程序
Daniel B Stamos,Lauren M Clubb,Apratim Mitra et al.
Daniel B Stamos et al.
Analysis of the transcriptional profiles of developing thymocytes has shown that T lineage commitment is associated with loss of stem cell and early progenitor gene signatures and the acquisition of T cell gene signatures. Less well underst...