Shu Hisata,Alexandra C Racanelli,Pouneh Kermani et al.
Shu Hisata et al.
Chronic obstructive pulmonary disease (COPD) is marked by airway inflammation and airspace enlargement (emphysema) leading to airflow obstruction and eventual respiratory failure. Microvasculature dysfunction is associated with COPD/emphyse...
Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma [0.03%]
整合应激反应的激活使黑色素瘤易受线粒体核糖体靶向抗生素的影响
Roberto Vendramin,Vicky Katopodi,Sonia Cinque et al.
Roberto Vendramin et al.
The ability to adapt to environmental stress, including therapeutic insult, contributes to tumor evolution and drug resistance. In suboptimal conditions, the integrated stress response (ISR) promotes survival by dampening cytosolic translat...
Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion [0.03%]
Foxo1通过调控黏液分泌控制肠道稳态和共生关系
Zuojia Chen,Jialie Luo,Jian Li et al.
Zuojia Chen et al.
Mucus produced by goblet cells in the gastrointestinal tract forms a biological barrier that protects the intestine from invasion by commensals and pathogens. However, the host-derived regulatory network that controls mucus secretion and th...
PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection [0.03%]
PGD2和CRTH2在寄生虫感染期间对抗2型细胞因子引起的肠上皮反应
Oyebola O Oyesola,Michael T Shanahan,Matt Kanke et al.
Oyebola O Oyesola et al.
Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote worm expulsion during intestinal helminth infection. How these epithelial responses are regulated remains incompletely underst...
Gautham Yepuri,Syed Nurul Hasan,Ann Marie Schmidt et al.
Gautham Yepuri et al.
In obesity complicated by hypertension, multicellular processes integrate to orchestrate cardiac fibrosis; the underlying mechanisms, however, remain elusive. In this issue of JEM, Cheng et al. (2021. J. Exp. Med. https://doi.org/10.1084/je...
Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity [0.03%]
转录因子Zhx2限制自然杀伤细胞的成熟并抑制其抗肿瘤免疫功能
Siyu Tan,Xiaowei Guo,Mengzhen Li et al.
Siyu Tan et al.
The maturation and functional competence of natural killer (NK) cells is a tightly controlled process that relies on transcription factors (TFs). Here, we identify transcriptional repressor zinc fingers and homeoboxes 2 (Zhx2) as a novel re...
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis [0.03%]
单细胞RNA测序分析识别银屑病皮肤中产生IL1B和IL23的CD14+树突状细胞群
Satoshi Nakamizo,Charles-Antoine Dutertre,Ahad Khalilnezhad et al.
Satoshi Nakamizo et al.
Inflammatory skin diseases including atopic dermatitis (AD) and psoriasis (PSO) are underpinned by dendritic cell (DC)-mediated T cell responses. Currently, the heterogeneous human cutaneous DC population is incompletely characterized, and ...
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity [0.03%]
遗传模型揭示了适应性免疫对潜伏结核分枝杆菌感染的差异化影响
Hongwei Su,Kan Lin,Divya Tiwari et al.
Hongwei Su et al.
Studying latent Mycobacterium tuberculosis (Mtb) infection has been limited by the lack of a suitable mouse model. We discovered that transient depletion of biotin protein ligase (BPL) and thioredoxin reductase (TrxB2) results in latent inf...
CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants [0.03%]
CD16⁺CD163⁺单核细胞在早产儿坏死性小肠结肠炎炎症部位的迁移
Oluwabunmi O Olaloye,Peng Liu,Jessica M Toothaker et al.
Oluwabunmi O Olaloye et al.
Necrotizing enterocolitis (NEC) is a severe gastrointestinal complication of prematurity. Using suspension and imaging mass cytometry coupled with single-cell RNA sequencing, we demonstrate severe inflammation in patients with NEC. NEC muco...
Impaired respiratory burst contributes to infections in PKCδ-deficient patients [0.03%]
PKCδ缺陷患者呼吸爆发功能受损导致易感染现象
Anna-Lena Neehus,Kunihiko Moriya,Alejandro Nieto-Patlán et al.
Anna-Lena Neehus et al.
Patients with autosomal recessive protein kinase C δ (PKCδ) deficiency suffer from childhood-onset autoimmunity, including systemic lupus erythematosus. They also suffer from recurrent infections that overlap with those seen in patients w...