The cytoskeleton contributes to abnormal genome-lamina interactions in LMNA-deficient cardiomyocytes [0.03%]
核纤层蛋白LMNA缺陷的心肌细胞中细胞骨架参与了异常的基因组-核纤层相互作用
Kaitlyn M Shen,Emily J Shields,Vasia Barka et al.
Kaitlyn M Shen et al.
The spatial organization of chromatin at the nuclear lamina contributes to genome structure and gene regulation. Mechanical inputs are increasingly recognized as key regulators of nuclear architecture, and understanding how they control gen...
Brenda I Cesar,Yumi Kim
Brenda I Cesar
A defining feature of meiosis is the synaptonemal complex (SC), a zipper-like protein structure that forms between homologous chromosomes to regulate their recombination and segregation. Historically viewed as an enigmatic electron-dense sc...
Carlotta Peselj,F-Nora Vögtle
Carlotta Peselj
In this issue, Yan et al. show that mitochondrial targeting signals (presequences) vary widely in import strength. Using the quantitative MitoLuc and PotLuc assays, they dissect multiple parameters of protein import and reveal how presequen...
Hiba Baaziz,Daniela Cimini
Hiba Baaziz
Micronucleus membrane rupture drives genome instability; however, the mechanisms governing this phenomenon remain unclear. Zych and colleagues reveal that impaired protein export, caused by reduced levels of the transport protein RCC1, driv...
Sidney W Whiteheart
Sidney W Whiteheart
In this issue, Ambrosio et al. (https://doi.org/10.1083/jcb.202507149) identify GRIP1-associated protein 1 as a key element in packaging both endocytosed and de novo-synthesized cargo into nascent α-granules of platelet-progenitor megakary...
Correction: Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II [0.03%]
订正：CKS-1介导的同源重组在减数第一次分裂中降解securin，在减数第二次分裂中降解cyclin B1以触发后期启动
Jie Yang,Eisuke Sumiyoshi,Bruce Bowerman
Jie Yang
OptoTAT reveals microtubule acetylation as a rapid trigger for GEF-H1-mediated cell migration [0.03%]
OptoTAT揭示微管乙酰化是GEF-H1介导的细胞迁移的快速触发因素
Abhijit Deb Roy,Cristian Saez Gonzalez,Milda Stanislauskas et al.
Abhijit Deb Roy et al.
Microtubule acetylation is implicated in regulating cell motility, yet its physiological role in directional migration and the underlying molecular mechanisms have remained unclear. This knowledge gap has persisted primarily due to a lack o...
Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion [0.03%]
单细胞转录组在集体侵袭中的时空动态变化及其关键调控机制
Priti Agarwal,Iska Maimon Zielonka,Hila Gingold et al.
Priti Agarwal et al.
Collective cell invasion underlies organ development, epithelial repair, and cancer metastasis. "Leader cells" remodel ECM, sense guidance cues, reorganize their cytoskeleton, and coordinate follower cells, but the molecular programs enabli...
A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells [0.03%]
PTPN23依赖的ESCRT途径是哺乳动物细胞固有分泌所必需的路径
Danièle Stalder,Conceição Pereira,Dick J H van den Boomen et al.
Danièle Stalder et al.
Secreted proteins are essential for processes like immune responses, cellular communication, and extracellular matrix remodeling. Once synthesized and processed at the Golgi, some of these proteins are packaged for delivery to the plasma me...
Angela K O Lwin,Alpha S Yap
Angela K O Lwin
The cell biology of tissues challenges us to understand how fundamental processes found in free living as well as communal cells are coordinated to achieve complex patterns of behavior on the scale of cellular populations. In this issue, So...