Océane Marescal,Kuan-Chung Su,Brittania Moodie et al.
Océane Marescal et al.
Quiescence is a state in which cells undergo a proliferative arrest while maintaining their capacity to divide again. Here, we analyze how cells regulate their centromeres during quiescence entry and exit. Despite the constitutive localizat...
Spatial inhibition of RhoA by RhoGAP15B promotes protrusive activity during collective migration [0.03%]
RhoGAP15B通过抑制RhoA促进集体迁移中的细胞突起作用
Vítor Yang,Cristian Marchant,Bing Liu et al.
Vítor Yang et al.
The Rho family GTPases RhoA, Rac1, and Cdc42 are well-established regulators of collective migration by driving the formation of cellular protrusions and by regulating actomyosin contraction and adhesion. However, how their activation and i...
Qi-Hong Zheng,Chengge Zhang,Ming-Xin Wang et al.
Qi-Hong Zheng et al.
A general mechanism to maintain epithelial integrity during tissue movements is to couple adhesion strength with mechanical force. Mechanosensitive proteins are recruited to cell-cell contacts to reinforce membrane-cortex linkage in respons...
Shyama Nandakumar,Deepika Vasudevan
Shyama Nandakumar
Cells in metabolically active tissues with high biosynthetic and secretory demands often use robust stress-responsive mechanisms to maintain homeostasis. Coordinating such stress response mechanisms requires intercellular communication and ...
The SWR1 complex prevents the vacuolar delivery of ATG proteins through a noncanonical pathway [0.03%]
SWR1复合体通过非经典途径阻止ATG蛋白转运至液泡
Siyu Fan,Huan Yang,Jianting Lei et al.
Siyu Fan et al.
Autophagy is a conserved catabolic process that relies on vacuoles or lysosomes. While autophagosome formation is well characterized, the mechanisms that prevent autophagy-related proteins form being enclosed by the autophagosome and degrad...
PI(3)P regulates mitochondrial dynamics through FGD-dependent actin organization [0.03%]
PI(3)P通过FGD依赖的肌动蛋白组织调节线粒体动力学
Shan Zhao,Jie Zhang,Tengfei Ma et al.
Shan Zhao et al.
Mitochondria form highly complex and dynamic networks to maintain their homeostasis. However, the underlying mechanisms remain elusive. Here we report a PI(3)P-dependent mechanism that regulates the mitochondrial dynamics required for forma...
Localized active transport shapes the nanoscopic features at the tip of mechanosensory cilia [0.03%]
局部活性运输在机械感觉纤毛尖端纳米级特征塑造中起作用
Shan Wang,Yue-Ting Hu,Yan-Rong Chen et al.
Shan Wang et al.
Cilia, despite sharing a conserved axonemal structure, display diverse structural and molecular features, particularly at their tips. This study uncovers a mechanism that shapes the molecular features of fly mechanosensory cilia tips throug...
Insights into retinal disease and non-tubulin glutamylation from a RPGR-TTLL5 complex structure [0.03%]
RPGR-TTLL5复合物结构揭示视网膜疾病和非微管蛋白泛谷氨酰胺化的新见解
James H Park,Richard J Y Liu,Xun Sun et al.
James H Park et al.
Mutations in retinitis pigmentosa GTPase regulator (RPGR) cause photoreceptor degeneration, vision loss, and eventual blindness. RPGR function requires glutamylation by tubulin tyrosine ligase-like 5 (TTLL5) whose mutation is also linked to...
A regional regulatory axis shapes enteroendocrine cell morphology and function [0.03%]
一个区域性的调控轴系决定了肠内分泌细胞的形态和功能
Haimeng Yu,Yongchao Zhang,Jingyuan Shi et al.
Haimeng Yu et al.
Enteroendocrine cells (EEs) are secretory cells in the gut epithelium that exist in two morphologically distinct forms: "open" and "closed." However, the mechanisms governing this morphological divergence remain unclear. Here, we show that ...
The KIF3B/B/KAP3 tail domain specifically facilitates TRIM46 transport to the axon initial segment [0.03%]
KIF3B/B/KAP3尾结构域特异性促进TRIM46向轴突初始段的运输
Xuguang Jiang,Sotaro Ichinose,Tadayuki Ogawa et al.
Xuguang Jiang et al.
Intracellular transport is essential for neuronal organization, yet how motor proteins achieve cargo selectivity remains incompletely understood. Kinesin-2 motors transport diverse cargos through the heterotrimeric KIF3/KAP3 complex, but wh...