Abdou Rachid Thiam,Maxime Carpentier
Abdou Rachid Thiam
Seipin is a conformationally flexible, oligomeric scaffold that regulates cellular lipid homeostasis beyond lipid droplet (LD) biogenesis. Seipin senses local lipid composition and membrane features to direct metabolic flux toward specific ...
Asymmetric mitochondrial trafficking balances perinuclear biogenesis to maintain network morphology [0.03%]
非对称线粒体运输平衡周质生物发生以维持网络形态
Julius Winter,Juan C Landoni,Keaton B Holt et al.
Julius Winter et al.
In functionally polarized cells, mitochondria can form distinct subpopulations, positioned at sites of varying metabolic and energetic demands. Thus far, the potential presence of such subpopulations and implications of their intracellular ...
Opposing actomyosin pools establish epithelial polarity during naive pluripotency exit [0.03%]
肌动蛋白肌球蛋白对抗建立上皮极性以终止 naive 多能性
Yu Shi,Nadia I Manzi,Nicole R Grater et al.
Yu Shi et al.
Epithelial cell polarity is fundamental for embryonic development and organ function. During organogenesis, epithelia often develop from unpolarized precursor cells. How mammalian epithelial cells establish polarity de novo is unclear, in p...
Glucose starvation signaling via nucleus-vacuole junction remodeling controls ergosterol synthesis [0.03%]
通过核 vac 窦重塑的葡萄糖饥饿信号传导控制麦角固醇合成
Shintaro Fujimoto,Yasushi Tamura
Shintaro Fujimoto
Membrane contact sites, where organelle membranes come into close proximity, function as dynamic hubs for lipid metabolism in response to metabolic and stress signals. In yeast, the nucleus-vacuole junction (NVJ) expands during glucose star...
A cytosolic IF1 reporter enables real-time visualization of severe mitochondrial membrane damage [0.03%]
一种细胞质IF1报告基因，能够实现在线实时监测严重的线粒体膜损伤事件
Erqing Gao,Liwei Guan,Kehang Zhang et al.
Erqing Gao et al.
Maintenance of mitochondrial integrity is fundamental for cellular survival, yet how cells recognize catastrophic mitochondrial membrane damage remains unknown. Here, we identify MAI-1 as the first genetically encoded reporter of severe mit...
Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis [0.03%]
Nedd4l通过使Neuroligin-2泛素化来控制发育期星形胶质细胞的形态发生
Kristina Sakers,Juan J Ramirez,Nimrod Elazar et al.
Kristina Sakers et al.
Central nervous system astrocytes have an intricate, highly branched morphology. Proper development of perisynaptic astrocyte processes is necessary for tripartite synapse formation and function. However, cellular pathways orchestrating thi...
Haoxi Wu,Ramanujan S Hegde
Haoxi Wu
We have curated and annotated the topologic determinants for all human membrane proteins made at the endoplasmic reticulum. This census of 4,863 proteins allowed us to systematically analyze the physical properties of their 20,546 transmemb...
E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity [0.03%]
E-和N-钙黏着蛋白通过调控RhoA活性的相反效应驱动肝极性和管腔延长
Junya Hayase,Li Yang,Yu-Heng Zhou et al.
Junya Hayase et al.
Hepatocytes display a unique polarity, forming narrow apical tubes-bile canaliculi (BCs)-between adjacent cells that are essential for liver function. Unlike most epithelial cells, hepatocytes express both E- and N-cadherin, yet their speci...
Jichao Sun,Mo Chen
Jichao Sun
Appalabhotla et al. (https://doi.org/10.1083/jcb.202507177) engineer a light-controlled version of PLC-γ1 (PLC-γ1) and show that activating it in an illuminated region of the cell membrane drives directional migration. The work redefines ...
Slow but steady: Molecular mechanisms controlling microtubule growth in centrioles and cilia [0.03%]
稳扎稳打：中心粒和纤毛中控制微管生长的分子机制
Saishree S Iyer,Anna Akhmanova
Saishree S Iyer
Microtubules are cytoskeletal filaments that form dynamic cytoplasmic arrays and stable cores of centrioles and cilia. Microtubule dynamics depend on GTP hydrolysis by tubulin: addition of GTP-tubulin creates a stabilizing cap, whereas cap ...