Role of the nonhelical tailpiece of myosin-II in regulating filament architecture and function [0.03%]
肌球蛋白-II非螺旋尾节在调节丝状结构和功能方面的的作用
Kangji Wang,Shi Shu,Xiong Liu et al.
Kangji Wang et al.
Mammalian nonmuscle myosin-II isoforms (NM-IIA, NM-IIB, and NM-IIC) each contain a nonhelical tailpiece (NHT) at their C terminus. Stop-codon mutations in the NHT of NM-IIA are linked to diseases such as macrothrombocytopenia. However, the ...
Andreas Boland
Andreas Boland
Feedback loops have been described as universal, recurring motifs that regulate major cell cycle transitions. In this issue, Williams et al. (https://doi.org/10.1083/jcb.202602088) show, however, that chromosome segregation synchrony in fis...
Sneha Ray,Aakanksha Singhvi
Sneha Ray
The complex structure of astrocytes allows for nervous system function; however, mechanisms underlying astrocyte morphogenesis remain unclear. Sakers et al. (https://doi.org/10.1083/jcb.202512111) find that astrocyte neuroligins (NLs) are f...
Fibroblast depletion reveals mammalian epithelial resilience across neonatal and adult stages [0.03%]
纤维母细胞耗竭揭示哺乳动物上皮在新生儿和成人阶段的恢复力
Isabella M Gaeta,Shuangshuang Du,Clémentine Villeneuve et al.
Isabella M Gaeta et al.
Regenerative organs, like the skin, depend on niche-stem cell interactions that sustain cellular turnover. In culture, skin fibroblasts promote epidermal stem cell proliferation and differentiation. Yet, it remains elusive how fibroblasts r...
Met-Vision reveals coexisting energetic states in tissue macrophages redistributed by inflammation [0.03%]
Met-Vision 揭示了由炎症重新分布的组织巨噬细胞中同时存在的活跃状态
Adriana Lecourieux,Margot Bardou,Zacarias Garcia et al.
Adriana Lecourieux et al.
The function of tissue-associated macrophages is tightly linked to their energy metabolism. Yet, the diversity of macrophage metabolic profiles coexisting in tissues at homeostasis or during immune challenges is incompletely understood. Her...
Redox-dependent S-glutathionylation of Aurora-A kinase by Gstp promotes postsynaptic maturation [0.03%]
Gstp通过硫氧还蛋白依赖的Aurora-A丝裂原活化蛋白激酶S-谷胱甘肽化促进突触后成熟
Shuji Wakatsuki,Akiko Yumoto,Takehiro Suzuki et al.
Shuji Wakatsuki et al.
Synapse formation relies on the precise orchestration of signaling pathways within postsynaptic compartments. Although we previously identified Aurora-A kinase as a promoter of synaptogenesis, the mechanism by which it is activated in postm...
Centriolar satellites assemble via a hierarchical pathway driven by PCM1 multimerization [0.03%]
PCM1多聚化驱动的中心粒卫星分层级聚合组装路径
Efe Begar,Ece Seyrek,Selin Yilmaz-Karaoglu et al.
Efe Begar et al.
Centriolar satellites (CS) are ubiquitous membraneless organelles with diverse functions and links to developmental and neuronal diseases. However, the molecular principles governing their assembly and regulation remain poorly understood. T...
Procollagen 1 assembles into phase-separated condensates in the endoplasmic reticulum [0.03%]
前胶原1在内质网中组装成相分离凝聚体
Soumya Bhattacharyya,Jose Wojnacki,Nathalie Brouwers et al.
Soumya Bhattacharyya et al.
Procollagen I (PC1) is assembled into a trimer within the lumen of the endoplasmic reticulum (ER). In vitro, collagen trimers form rigid molecules reaching lengths of up to 400 nm, and this conformation is presumed to represent their assemb...
Early architects: Eosinophils promote postnatal development of the small intestinal villus structure [0.03%]
早肠造诣者：嗜酸性粒细胞促进小肠绒毛结构的发育
Nicola Laura Diny
Nicola Laura Diny
Smooth muscle cells in the intestinal villus form early postnatally and aid the uptake of dietary fats. In this issue, Petrova et al. (https://doi.org/10.1083/jcb.202505012) describe a second postnatal wave of smooth muscle cell formation f...
Mitochondria limit coenzyme Q export under cholesterol biosynthetic stress [0.03%]
线粒体限制辅酶Q的输出以应对胆固醇生物合成压力
Marjana Ndoci,Sharanya Bhattacharya,Ishita Agrawal et al.
Marjana Ndoci et al.
Coenzyme Q (CoQ) is a hydrophobic lipid primarily synthesized in the mitochondria, though it is also present in non-mitochondrial membranes. However, the metabolic pathways that regulate intracellular CoQ distribution are unknown. This stud...