Mitoguardin-2-mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation [0.03%]
线粒体脂质转移维持线粒体形态和脂滴形成的作用机制研究
Zhouping Hong,Jyoti Adlakha,Neng Wan et al.
Zhouping Hong et al.
Lipid transport proteins at membrane contacts, where organelles are closely apposed, are critical in redistributing lipids from the endoplasmic reticulum (ER), where they are made, to other cellular membranes. Such protein-mediated transfer...
Yujuan Fu,Yaxin Liu,Tanye Wen et al.
Yujuan Fu et al.
RNA polymerase I (Pol I) synthesizes about 60% of cellular RNA by transcribing multiple copies of the ribosomal RNA gene (rDNA). The transcriptional activity of Pol I controls the level of ribosome biogenesis and cell growth. However, there...
RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes [0.03%]
RUFY1与Arl8b结合介导网格蛋白包被的早期内体到TGN囊泡的CI-M6PR回取，从而将货物分选至溶酶体中
Shalini Rawat,Dhruba Chatterjee,Rituraj Marwaha et al.
Shalini Rawat et al.
Arl8b, an Arf-like GTP-binding protein, regulates cargo trafficking and positioning of lysosomes. However, it is unknown whether Arl8b regulates lysosomal cargo sorting. Here, we report that Arl8b binds to the Rab4 and Rab14 interaction par...
Hemicentin-mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage [0.03%]
半纤连介导的IV型胶原组装可加强相邻基底膜连接
Claire A Gianakas,Daniel P Keeley,William Ramos-Lewis et al.
Claire A Gianakas et al.
Basement membrane (BM) matrices surround and separate most tissues. However, through poorly understood mechanisms, BMs of adjacent tissue can also stably link to support organ structure and function. Using endogenous knock-in fluorescent pr...
APC/CCdc20-mediated degradation of Clb4 prompts astral microtubule stabilization at anaphase onset [0.03%]
CLB4的APC/C CDC20依赖性降解稳定了赤道板分裂前期的星状微管
Federico Zucca,Clara Visintin,Jiaming Li et al.
Federico Zucca et al.
Key for accurate chromosome partitioning to the offspring is the ability of mitotic spindle microtubules to respond to different molecular signals and remodel their dynamics accordingly. Spindle microtubules are conventionally divided into ...
Lucia Morgado-Palacin
Lucia Morgado-Palacin
Elvan Böke investigates the mechanisms that preserve the viability of dormant oocytes. © 2022 Morgado-Palacin.
Ian A Windham,Sarah Cohen
Ian A Windham
Lipid droplets (LDs) are key organelles for fat storage and trafficking. In this issue, Rogers et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202205053) show that glucose restriction triggers liquid crystalline lattice formation wit...
Allyson F O&#x;Donnell
Allyson F O&#x;Donnell
Post-endocytic recycling in yeast has been posited to transit solely through the Golgi, raising the possibility that yeast lack early endosomes. In this issue, Laidlaw and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202109137...
Plant autophagosomes mature into amphisomes prior to their delivery to the central vacuole [0.03%]
植物自噬体在递送至中央液泡之前成熟为氨菲苏体
Jierui Zhao,Mai Thu Bui,Juncai Ma et al.
Jierui Zhao et al.
Autophagosomes are double-membraned vesicles that traffic harmful or unwanted cellular macromolecules to the vacuole for recycling. Although autophagosome biogenesis has been extensively studied, autophagosome maturation, i.e., delivery and...
Nikoline Lander Rasmussen,Athanasios Kournoutis,Trond Lamark et al.
Nikoline Lander Rasmussen et al.
NBR1 was discovered as an autophagy receptor not long after the first described vertebrate autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while NBR1 is mentioned in