Stress-induced nucleolar rejuvenation via chaperone-mediated segregation in a filamentous fungus [0.03%]
分子伴侣介导的丝状真菌应激诱导核仁年轻化现象及机制研究
Audra M Rogers,Brenna K Broussard,Rachel Taylor et al.
Audra M Rogers et al.
How the nucleolus recovers from acute proteostatic stress, particularly in multinucleate syncytia, remains poorly understood. In the highly polarized hyphae of the model filamentous fungus Magnaporthe oryzae, we uncover a novel stress-induc...
Tetraspanin CD82 shapes EGFR signaling outcomes through nanoscale receptor organization [0.03%]
四次跨膜蛋白CD82通过纳米级受体分布调控EGFR信号转导效应
Sebastian Restrepo Cruz,Michael J Wester,Vernon S Pankratz et al.
Sebastian Restrepo Cruz et al.
Tetraspanins are integral membrane proteins that play a crucial role in organizing and regulating cellular signaling by serving as scaffolds that compartmentalize receptors and other signaling molecules within membrane microdomains. Here, w...
Angelina S Kim,Jing Ze Wu,Ruiqi Cai et al.
Angelina S Kim et al.
Lysosomes are subject to perturbations that can cause damage to their limiting membrane. Osmotic shifts, pore-forming toxins, and the growth of luminal polymers or pathogens all stand to increase lysosomal membrane tension and/or disrupt th...
Reversible one-way lipid transfer at ER-autophagosome membrane contact sites via Atg2 [0.03%]
Atg2介导的内质网-自噬体接触位点的可逆单向脂质转移
Li Hao,Tomoki Midorikawa,Yuta Ogasawara et al.
Li Hao et al.
Bridge-like lipid transfer proteins (LTPs) contain a repeating β-groove domain and long hydrophobic grooves that act as bridges at membrane contact sites (MCSs) to efficiently transfer lipids. Atg2 is one such bridge-like LTP essential for...
Distinct TRAPP complexes activate Ypt/Rab GTPases in secretion and autophagy [0.03%]
不同的TRAPP复合物在分泌和自噬中激活Ypt / Rab GTP酶
Valeriya Gyurkovska,Rakhilya Murtazina,Sarah F Zhao et al.
Valeriya Gyurkovska et al.
The conserved Ypt/Rab GTPases regulate all steps of the intracellular transport pathways. In yeast and human cells, Ypt1/Rab1 regulate early steps of secretion and autophagy, whereas Ypt31/Rab11 regulate a late step in secretion, and the TR...
Hoi1 targets BLTP2 to ER-PM contact sites to regulate lipid homeostasis [0.03%]
HOI1通过靶向BLTP2到内质网-质膜接触位点来调节脂类稳态
Samantha K Dziurdzik,Vaishnavi Sridhar,Hailey Eng et al.
Samantha K Dziurdzik et al.
Membrane contact sites between organelles are important for maintaining cellular lipid homeostasis. Members of the recently identified family of bridge-like lipid transfer proteins (BLTPs) span apposing membranes at these contact sites to e...
Two δ-catenins, plakophilin 4 and p120, promote formation of distinct types of adherens junctions [0.03%]
两个δ-catenin、plakophilin 4和p120促进不同类型的粘着斑连接的形成
Indrajyoti Indra,Regina B Troyanovsky,Farida V Korobova et al.
Indrajyoti Indra et al.
Classical cadherins are instrumental for connecting cells into tissues by forming adherens junctions (AJs), a structurally diverse class of cell-cell adhesions tailored to specific membrane domains, cell types, and particular functions. The...
Cdc5-mediated Ulp2 phosphorylation controls the timing of polySUMOylation during the cell cycle [0.03%]
CDC5介导的Ulp2磷酸化控制细胞周期中Poly-SUMO链形成的时机
Emily Gutierrez-Morton,Raed Rizkallah,Tomiwa Lawal et al.
Emily Gutierrez-Morton et al.
SUMOylation is a posttranslational modification, and polySUMOylation can further trigger protein ubiquitination and relocalization to facilitate cell cycle progression. Previous studies show cell cycle-dependent polySUMOylation in budding y...
Better reporting is better science: Community-defined minimal reporting requirements for light microscopy [0.03%]
更好的报告才能更好地进行科学研究——由社区定义的显微镜成像技术最小化报告要求
Paula Montero Llopis,Chloë van Oostende-Triplet,Nathalie Gaudreault et al.
Paula Montero Llopis et al.
Incomplete reporting of microscopy methods undermines transparency, reproducibility, and data reuse. Despite recent initiatives, comprehensive, broadly endorsed, and accessible reporting guidelines are still lacking. Here, we present a bare...
An inducible multiciliated cell line resolves proteome dynamics and identifies CDK7 as a conserved regulator [0.03%]
一个可诱导的多纤毛细胞系确定了蛋白质组动力学并识别出CDK7是一种保守的调节因子
Camille Boutin,Olivier Rosnet,Marine Touret et al.
Camille Boutin et al.
Multiciliated cells (MCCs) are essential for generating directional fluid flow across specialized epithelia in various vertebrate organs. MCC differentiation involves a tightly regulated program characterized by massive centriole amplificat...