Distinct roles of light-activated channels TRP and TRPL in photoreceptors of Periplaneta americana [0.03%]
美洲蜚蠊视网膜中光激活通道TRP和TRPL的独立作用机制
Paulus Saari,Andrew S French,Päivi H Torkkeli et al.
Paulus Saari et al.
Electrophysiological studies in Drosophila melanogaster and Periplaneta americana have found that the receptor current in their microvillar photoreceptors is generated by two light-activated cationic channels, TRP (transient receptor potent...
Tanmay Chavan,Merritt Maduke,Kenton Swartz
Tanmay Chavan
Chavan et al. highlight work showing that a monobody can inhibit a fluoride channel using a mechanism similar to that of a scorpion toxin blocker of potassium channels.
László Csanády
László Csanády
Csanády discusses a new study that provides insight into the unique conductance properties of the CFTR chloride channel.
Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants [0.03%]
局麻药、抗心律失常和抗惊厥药物阻滞钠通道的机制
Denis B Tikhonov,Boris S Zhorov
Denis B Tikhonov
Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about ...
Mechanism of single- and double-sided inhibition of dual topology fluoride channels by synthetic monobodies [0.03%]
合成单体对双重拓扑氟化物通道的单向和双向抑制机制
Daniel L Turman,Randy B Stockbridge
Daniel L Turman
The Fluc family of proteins comprises small, electrodiffusive fluoride channels, which prevent accumulation of toxic F- ions in microorganisms. Recent crystal structures have confirmed their unusual architecture, in which a pair of antipara...
Probing the conformation of a conserved glutamic acid within the Cl- pathway of a CLC H+/Cl- exchanger [0.03%]
研究CLC H+/Cl-交换器中Cl-通道内的保守性谷氨酸残基的构象状态
Malvin Vien,Daniel Basilio,Lilia Leisle et al.
Malvin Vien et al.
The CLC proteins form a broad family of anion-selective transport proteins that includes both channels and exchangers. Despite extensive structural, functional, and computational studies, the transport mechanism of the CLC exchangers remain...
Teresa Giraldez,Brad S Rothberg
Teresa Giraldez
Regulator of conduction of K+ (RCK) domains are ubiquitous regulators of channel and transporter activity in prokaryotes and eukaryotes. In humans, RCK domains form an integral component of large-conductance calcium-activated K channels (BK...
Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR [0.03%]
CFTR预水解和后水解开环状态的静电调节
Jingyao Zhang,Tzyh-Chang Hwang
Jingyao Zhang
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that couples adenosine triphosphate (ATP) hydrolysis at its nucleotide-binding domains to gating transitions in its transmembrane domains. We previously reported t...
Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains [0.03%]
DIII和DIV电压感受域对钠通道失活的调节作用
Eric J Hsu,Wandi Zhu,Angela R Schubert et al.
Eric J Hsu et al.
Functional eukaryotic voltage-gated Na+ (NaV) channels comprise four domains (DI-DIV), each containing six membrane-spanning segments (S1-S6). Voltage sensing is accomplished by the first four membrane-spanning segments (S1-S4), which toget...
Acting on an impulse (or two): Advantages of high-frequency tetanic onset in skeletal muscle [0.03%]
冲动行事（或两次）：骨骼肌高频tetanus发生的优势
Richard L Moss,Thomas L Lynch th,Daniel P Fitzsimons
Richard L Moss
Moss et al. highlight why high-frequency bursts at the onset of tetany increase force development in fast-twitch skeletal muscle fibers.