Tension-activated channels in the mechanism of osmotic fitness in Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌渗透压适应的张力激活通道机制研究
Uğur Çetiner,Ian Rowe,Anthony Schams et al.
Uğur Çetiner et al.
Pseudomonas aeruginosa (PA) is an opportunistic pathogen with an exceptional ability to adapt to a range of environments. Part of its adaptive potential is the ability to survive drastic osmolarity changes. Upon a sudden dilution of externa...
Caitlin Sedwick
Caitlin Sedwick
A new study explains Pseudomonas aeruginosa's strong resistance to osmotic down-shock. © 2017 Rockefeller University Press.
Isoflurane modulates activation and inactivation gating of the prokaryotic Na+ channel NaChBac [0.03%]
异氟烷调控原核钠离子通道NaChBac的激活和失活_gate_operating
Rheanna M Sand,Kevin J Gingrich,Tamar Macharadze et al.
Rheanna M Sand et al.
Voltage-gated Na+ channels (Nav) have emerged as important presynaptic targets for volatile anesthetic (VA) effects on synaptic transmission. However, the detailed biophysical mechanisms by which VAs modulate Nav function remain unclear. VA...
Identifiability, reducibility, and adaptability in allosteric macromolecules [0.03%]
变构大分子中的识别性、可缩减性和适应性
Gergő Bohner,Gaurav Venkataraman
Gergő Bohner
The ability of macromolecules to transduce stimulus information at one site into conformational changes at a distant site, termed "allostery," is vital for cellular signaling. Here, we propose a link between the sensitivity of allosteric ma...
Control of Kir channel gating by cytoplasmic domain interface interactions [0.03%]
调控Kir通道门控的胞质结构域界面相互作用
William F Borschel,Shizhen Wang,Sunjoo Lee et al.
William F Borschel et al.
Inward rectifier potassium (Kir) channels are expressed in almost all mammalian tissues and play critical roles in the control of excitability. Pancreatic ATP-sensitive K (KATP) channels are key regulators of insulin secretion and comprise ...
A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore [0.03%]
电压传感器和孔道之间的钾通道KV10.1的新电压依赖性闸门机制
Adam P Tomczak,Jorge Fernández-Trillo,Shashank Bharill et al.
Adam P Tomczak et al.
Voltage-gated ion channels couple transmembrane potential changes to ion flow. Conformational changes in the voltage-sensing domain (VSD) of the channel are thought to be transmitted to the pore domain (PD) through an α-helical linker betw...
Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue [0.03%]
无颌类T型Ca2+通道同源物的进化新见解：结构、功能和离子选择性方面的研究
Carolyn L Smith,Salsabil Abdallah,Yuen Yan Wong et al.
Carolyn L Smith et al.
Four-domain voltage-gated Ca2+ (Cav) channels play fundamental roles in the nervous system, but little is known about when or how their unique properties and cellular roles evolved. Of the three types of metazoan Cav channels, Cav1 (L-type)...
Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9 [0.03%]
活体哺乳动物视杆细胞的闪光反应恢复速度受RGS9限制
Gabriel Peinado Allina,Christopher Fortenbach,Franklin Naarendorp et al.
Gabriel Peinado Allina et al.
The temporal resolution of scotopic vision is thought to be constrained by the signaling kinetics of retinal rods, which use a highly amplified G-protein cascade to transduce absorbed photons into changes in membrane potential. Much is know...
The glass micropipette electrode: A history of its inventors and users to 1950 [0.03%]
玻璃微吸管电极：其发明者及使用者的历史（直到1950年）
Allan H Bretag
Allan H Bretag
Soon after the glass micropipette was invented as a micro-tool for manipulation of single bacteria and the microinjection and microsurgery of living cells, it was seen to hold promise as a microelectrode to stimulate individual cells electr...
Caitlin Sedwick
Caitlin Sedwick
New simulations explain how several types of drugs block sodium channels. © 2017 Rockefeller University Press.