The intricacies of atrial calcium cycling during excitation-contraction coupling [0.03%]
心肌兴奋收缩偶联过程中心房钙循环的复杂性
Lothar A Blatter
Lothar A Blatter
Blatter discusses the initiation and spread of Ca release, Ca store depletion, and release termination in atrial myocytes.
Ambiguous interactions between diastolic and SR Ca2+ in the regulation of cardiac Ca2+ release [0.03%]
心肌舒张期和SR内钙离子的相互作用在心肌钙释放调控中的作用及机制研究
Eric A Sobie,George S B Williams,W J Lederer
Eric A Sobie
Sobie et al. highlight unresolved issues concerning the regulation of sarcoplasmic reticulum calcium release in cardiac myocytes.
The Junior Faculty Networking Cohort: Filling a gap in support for our community [0.03%]
初级教职员工网络小组：填补我们社区支持的空白
Sharona E Gordon
Sharona E Gordon
JGP, in partnership with the Society of General Physiologists, announces a new networking and mentoring program for junior faculty. © 2017 Rockefeller U...
Rene Barro-Soria,Sara I Liin,H Peter Larsson
Rene Barro-Soria
Barro-Soria et al. highlight work that reveals how β1 and β3 subunits modulate NaV1.5 channel function.
Wandi Zhu,Taylor L Voelker,Zoltan Varga et al.
Wandi Zhu et al.
Voltage-gated Na+ (NaV) channels comprise a macromolecular complex whose components tailor channel function. Key components are the non-covalently bound β1 and β3 subunits that regulate channel gating, expression, and pharmacology. Here, ...
Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel [0.03%]
PI(4,5)P2门控G蛋白门控钾通道中固定螺旋的作用机制研究
Emre Lacin,Prafulla Aryal,Ian W Glaaser et al.
Emre Lacin et al.
G protein-gated inwardly rectifying potassium (GIRK) channels control neuronal excitability in the brain and are implicated in several different neurological diseases. The anionic phospholipid phosphatidylinositol 4,5 bisphosphate (PIP2) is...
Caitlin Sedwick
Caitlin Sedwick
JGP study shows how synaptotagmins 1 and 7 affect chromaffin cell granule fusion. © 2017 Rockefeller University Press.
Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules [0.03%]
不同突触素同工型赋予肾上腺嗜铬细胞颗粒不同的激活速率和动力学性质
Tejeshwar C Rao,Zuleirys Santana Rodriguez,Mazdak M Bradberry et al.
Tejeshwar C Rao et al.
Adrenomedullary chromaffin cells respond to sympathetic nervous system activation by secreting a cocktail of potent neuropeptides and hormones into the circulation. The distinct phases of the chromaffin cell secretory response have been att...
Emely Thompson,Jodene Eldstrom,Maartje Westhoff et al.
Emely Thompson et al.
The delayed potassium rectifier current, IKs , is composed of KCNQ1 and KCNE1 subunits and plays an important role in cardiac action potential repolarization. During β-adrenergic stimulation, 3'-5'-cyclic adenosine monophosphate (cAMP)-dep...
Correction: Clustering of Ca2+ transients in interstitial cells of Cajal defines slow wave duration [0.03%]
纠正：Cajal间质细胞中Ca２⁺瞬变的聚类定义了慢波的持续时间
Bernard T Drumm,Grant W Hennig,Matthew J Battersby et al.
Bernard T Drumm et al.
Published Erratum
The Journal of general physiology. 2017 Jul 3;149(7):751. DOI:10.1085/jgp.20171177106142017c 2017