100 years and counting: JGP celebrates its centenary [0.03%]
继往百年，开来无限：《 Journal of General Physiology 》创刊一百周年纪念
Sharona E Gordon
Sharona E Gordon
As JGP approaches its 100th year, dissemination of science is more important than ever. © 2017 Gordon.
Caitlin Sedwick
Caitlin Sedwick
New JGP study models how sinoatrial node pacemaker activity changes in aged hearts. © 2017 Rockefeller University Press.
Chemistry in a vesicle [0.03%]
囊泡中的化学反应
Meyer B Jackson
Meyer B Jackson
Slow fusion pore expansion could retain molecules within vesicles, enabling a chemical reaction that modifies secreted products.
Age-related pacemaker deterioration is due to impaired intracellular and membrane mechanisms: Insights from numerical modeling [0.03%]
基于数值模拟的年龄相关起搏器退化是由于细胞内和膜机制受损所致
Joachim Behar,Yael Yaniv
Joachim Behar
Age-related deterioration of pacemaker function has been documented in mammals, including humans. In aged isolated sinoatrial node tissues and cells, reduction in the spontaneous action potential (AP) firing rate was associated with deterio...
A coarse-grained computational model of the nuclear pore complex predicts Phe-Gly nucleoporin dynamics [0.03%]
核孔复合物的粗粒化计算模型预测Phe-Gly核孔蛋白动力学
Joan Pulupa,Manas Rachh,Michael D Tomasini et al.
Joan Pulupa et al.
The phenylalanine-glycine-repeat nucleoporins (FG-Nups), which occupy the lumen of the nuclear pore complex (NPC), are critical for transport between the nucleus and cytosol. Although NPCs differ in composition across species, they are larg...
Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo [0.03%]
缓慢的融合孔扩张为共包装货物创建了一个独特的反应室
Kevin P Bohannon,Mary A Bittner,Daniel A Lawrence et al.
Kevin P Bohannon et al.
A lumenal secretory granule protein, tissue plasminogen activator (tPA), greatly slows fusion pore dilation and thereby slows its own discharge. We investigated another outcome of the long-lived narrow fusion pore: the creation of a nanosca...
Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2 [0.03%]
心肌ryanodine受体的调控作用及其腔内Ca2+的影响
Peter P Jones,Wenting Guo,S R Wayne Chen
Peter P Jones
Jones et al. propose that SR luminal Ca2+ regulates RyR2 activity via a luminal Ca2+ sensor distinct from the cytosolic Ca2+ sensor.
Quenching the spark: Termination of CICR in the submicroscopic space of the dyad [0.03%]
熄灭微小二联体间隙空间中的火花：CICR在亚微观空间中的终止现象
Mark B Cannell,Cherrie H T Kong
Mark B Cannell
Cannell and Kong discuss the different termination mechanisms proposed for CICR in cardiac myocytes.
The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis [0.03%]
腔内钙离子调节在钙信号不应性和心律失常中的作用
Sándor Györke,Andriy E Belevych,Bin Liu et al.
Sándor Györke et al.
Györke et al. discuss the role of sarcoplasmic reticulum Ca2+ in cardiac refractoriness and pathological implications.
Perspectives on "Control of Ca release from within the cardiac sarcoplasmic reticulum" [0.03%]
“关于心肌细胞内钙释放调控的几点思考”观点与点评论文
Eduardo Ríos
Eduardo Ríos
Five groups of experts unravel the complex modulation of a function crucial for the beating heart.