Han-I Yeh,Yoshiro Sohma,Katja Conrath et al.
Han-I Yeh et al.
Cystic fibrosis (CF) is a channelopathy caused by loss-of-function mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a phosphorylation-activated and adenosine triphosphate (ATP)-gated chloride c...
Thermodynamic cooperativity of cosubstrate binding and cation selectivity of Salmonella typhimurium MelB [0.03%]
副底物结合的热力学协同作用及沙门氏菌MelB的阳离子选择性
Parameswaran Hariharan,Lan Guan
Parameswaran Hariharan
The Na+-coupled melibiose symporter MelB, which can also be coupled to H+ or Li+ transport, is a prototype for the glycoside-pentoside-hexuronide:cation symporter family. Although the 3-D x-ray crystal structure of Salmonella typhimurium Me...
Hans-Jürgen Apell
Hans-Jürgen Apell
Insufficient sodium-ion extrusion by mutated Na+,K+-ATPases causes hyperaldosteronism.
Caitlin Sedwick
Caitlin Sedwick
New JGP study explores the thermodynamic cycle and cation preference of the sugar symporter MelB. © 2017 Rockefeller University Press.
Dylan J Meyer,Craig Gatto,Pablo Artigas
Dylan J Meyer
Primary aldosteronism, a condition in which too much aldosterone is produced and that leads to hypertension, is often initiated by an aldosterone-producing adenoma within the zona glomerulosa of the adrenal cortex. Somatic mutations of ATP1...
Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel [0.03%]
将哺乳动物Slo1通道的生物物理特性与无脊椎动物Slo1通道结构相结合
Yu Zhou,Huanghe Yang,Jianmin Cui et al.
Yu Zhou et al.
For those interested in the machinery of ion channel gating, the Ca2+ and voltage-activated BK K+ channel provides a compelling topic for investigation, by virtue of its dual allosteric regulation by both voltage and intracellular Ca2+ and ...
Jon T Sack
Jon T Sack
Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and sm...
The voltage sensor of excitation-contraction coupling in mammals: Inactivation and interaction with Ca2 [0.03%]
哺乳动物兴奋收缩耦联的电压感受器：失活和与Ca2+的作用
Juan Ferreira Gregorio,Germán Pequera,Carlo Manno et al.
Juan Ferreira Gregorio et al.
In skeletal muscle, the four-helix voltage-sensing modules (VSMs) of CaV1.1 calcium channels simultaneously gate two Ca2+ pathways: the CaV1.1 pore itself and the RyR1 calcium release channel in the sarcoplasmic reticulum. Here, to gain ins...
Epithelial transport in The Journal of General Physiology [0.03%]
《_journal of general physiology_》上的上皮转运论文
Lawrence G Palmer
Lawrence G Palmer
Epithelia define the boundaries of the body and often transfer solutes and water from outside to inside (absorption) or from inside to outside (secretion). Those processes involve dual plasma membranes with different transport components th...
The enduring legacy of the "constant-field equation" in membrane ion transport [0.03%]
膜离子转运中的“恒定场方程”的长久影响
Osvaldo Alvarez,Ramon Latorre
Osvaldo Alvarez
In 1943, David Goldman published a seminal paper in The Journal of General Physiology that reported a concise expression for the membrane current as a function of ion concentrations and voltage. This body of work was, and still is, the theo...