Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels [0.03%]
能掩蔽电压门控型Cav2.2钙通道的钙离子依赖性易化作用的分子结构部位
Jessica R Thomas,Jussara Hagen,Daniel Soh et al.
Jessica R Thomas et al.
Voltage-gated Cav2.1 (P/Q-type) Ca2+ channels undergo Ca2+-dependent inactivation (CDI) and facilitation (CDF), both of which contribute to short-term synaptic plasticity. Both CDI and CDF are mediated by calmodulin (CaM) binding to sites i...
Michael Jaehme,Rajkumar Singh,Alisa A Garaeva et al.
Michael Jaehme et al.
Membrane transporters of the bacterial pyridine nucleotide uptake (Pnu) family mediate the uptake of various B-type vitamins. For example, the PnuT transporters have specificity for vitamin B1 (thiamine). It has been hypothesized that Pnu t...
Integrative model of coronary flow in anatomically based vasculature under myogenic, shear, and metabolic regulation [0.03%]
基于解剖的血管结构在肌源性、剪切性和代谢调节下的冠状流量整合模型
Ravi Namani,Ghassan S Kassab,Yoram Lanir
Ravi Namani
Coronary blood flow is regulated to match the oxygen demand of myocytes in the heart wall. Flow regulation is essential to meet the wide range of cardiac workload. The blood flows through a complex coronary vasculature of elastic vessels ha...
A new model for an old friend [0.03%]
老友新模型
Caitlin Sedwick
Caitlin Sedwick
JGP study suggests the anion exchanger AE1 operates via an elevator-like mechanism. © 2017 Rockefeller University Press.
Asymmetry of inverted-topology repeats in the AE1 anion exchanger suggests an elevator-like mechanism [0.03%]
AE1阴离子交换器中倒置拓扑重复序列的不对称性表明存在电梯样机制
Emel Ficici,José D Faraldo-Gómez,Michael L Jennings et al.
Emel Ficici et al.
The membrane transporter anion exchanger 1 (AE1), or band 3, is a key component in the processes of carbon-dioxide transport in the blood and urinary acidification in the renal collecting duct. In both erythrocytes and the basolateral membr...
An atypical CaV1.1 mutation reveals a common mechanism for hypokalemic periodic paralysis [0.03%]
发现一种罕见的CaV1.1突变揭示了低钾血症周期性瘫痪的普遍致病机制
Stephen C Cannon
Stephen C Cannon
Cannon reviews new evidence supporting a key role for anomalous inward currents in the etiology of hypokalemic periodic paralysis.
Gerhard Meissner
Gerhard Meissner
Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic reticulum. There are three mammalian RyR isoforms: RyR1 is present in ...
Na leak with gating pore properties in hypokalemic periodic paralysis V876E mutant muscle Ca channel [0.03%]
低钾血症周期性瘫痪V876E突变体肌肉Ca通道的Na泄漏电流具有 gating pore 性质
Clarisse Fuster,Jimmy Perrot,Christine Berthier et al.
Clarisse Fuster et al.
Type 1 hypokalemic periodic paralysis (HypoPP1) is a poorly understood genetic neuromuscular disease characterized by episodic attacks of paralysis associated with low blood K+ The vast majority of HypoPP1 mutations involve the replacement ...
Chasing the open-state structure of pentameric ligand-gated ion channels [0.03%]
追逐五聚体配体门控离子通道开放状态的结构
Giovanni Gonzalez-Gutierrez,Yuhang Wang,Gisela D Cymes et al.
Giovanni Gonzalez-Gutierrez et al.
Remarkable advances have been made toward the structural characterization of ion channels in the last two decades. However, the unambiguous assignment of well-defined functional states to the obtained structural models has proved challengin...
Analysis of the quality of crystallographic data and the limitations of structural models [0.03%]
晶体学数据的质量分析及结构模型的局限性
Valentina Arkhipova,Albert Guskov,Dirk-Jan Slotboom
Valentina Arkhipova
Crystal structures provide visual models of biological macromolecules, which are widely used to interpret data from functional studies and generate new mechanistic hypotheses. Because the quality of the collected x-ray diffraction data dire...