Voltage modulates halothane-triggered Ca2+ release in malignant hyperthermia-susceptible muscle [0.03%]
电压调节卤仿诱发的恶性高热易感肌肉中的钙释放
Alberto Zullo,Martin Textor,Philipp Elischer et al.
Alberto Zullo et al.
Malignant hyperthermia (MH) is a fatal hypermetabolic state that may occur during general anesthesia in susceptible individuals. It is often caused by mutations in the ryanodine receptor RyR1 that favor drug-induced release of Ca2+ from the...
The prokaryotic Na+/Ca2+ exchanger NCX_Mj transports Na+ and Ca2+ in a 3:1 stoichiometry [0.03%]
拟南芥Nramp金属转运蛋白通过质子驱动力转运铁和 manganese
Irina Shlosman,Fabrizio Marinelli,José D Faraldo-Gómez et al.
Irina Shlosman et al.
Intracellular Ca2+ signals control a wide array of cellular processes. These signals require spatial and temporal regulation of the intracellular Ca2+ concentration, which is achieved in part by a class of ubiquitous membrane proteins known...
Differential contribution of Ca2+ sources to day and night BK current activation in the circadian clock [0.03%]
钙离子来源对昼夜节律钟中BK电流激活的差异贡献
Joshua P Whitt,Beth A McNally,Andrea L Meredith
Joshua P Whitt
Large conductance K+ (BK) channels are expressed widely in neurons, where their activation is regulated by membrane depolarization and intracellular Ca2+ (Ca2+i). To enable this regulation, BK channels functionally couple to both voltage-ga...
Christian Aalkjær,Ole Bækgaard Nielsen
Christian Aalkjær
Aalkjær and Nielsen discuss new data revealing the basis of acid–base transport in t-tubules of skeletal muscle.
Zachary M James,William N Zagotta
Zachary M James
Cyclic nucleotide-binding domain (CNBD) channels are a family of ion channels in the voltage-gated K+ channel superfamily that play crucial roles in many physiological processes. CNBD channels are structurally similar but functionally very ...
Clay M Armstrong,Stephen Hollingworth
Clay M Armstrong
We are wired with conducting cables called axons that rapidly transmit electrical signals (e.g., "Ouch!") from, for example, the toe to the spinal cord. Because of the high internal resistance of axons (salt water rather than copper), a sig...
Revisiting multimodal activation and channel properties of Pannexin 1 [0.03%]
revisit Pannexin 1的多模态激活和通道属性
Yu-Hsin Chiu,Michael S Schappe,Bimal N Desai et al.
Yu-Hsin Chiu et al.
Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed throughout the body. Panx1 activation results in the release of nucleotides such as adenosine triphosphate and uridine triphosphate. Thus, these channels have b...
Uncorking AMPA receptors [0.03%]
揭开AMPA受体之谜
Caitlin Sedwick
Caitlin Sedwick
New JGP study explains how auxiliary proteins relieve polyamine block of AMPARs. © 2018 Rockefeller University Press.
NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat [0.03%]
大鼠快缩肌纤维管腔系统膜上的电中性和扩散决定的氢离子转运
Bradley S Launikonis,Tanya R Cully,Laszlo Csernoch et al.
Bradley S Launikonis et al.
The complex membrane structure of the tubular system (t-system) in skeletal muscle fibers is open to the extracellular environment, which prevents measurements of H+ movement across its interface with the cytoplasm by conventional methods. ...
Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation [0.03%]
Stargazin和Cornichon-3通过增强阻断剂的渗透作用来缓解多胺对AMPA受体的阻断作用
Patricia M G E Brown,Hugo McGuire,Derek Bowie
Patricia M G E Brown
Most ligand- and voltage-gated ion channels assemble as signaling complexes consisting of pore-forming and auxiliary subunits. In the mammalian brain, AMPA-type ionotropic glutamate receptors (AMPARs) coassemble with several families of aux...