Prediction and biological significance of small changes in binding of leiomodin to tropomyosin [0.03%]
球形碎石子蛋白与肌动蛋白结合的微小变化及其生物学意义预测
Eduardo Sánchez Díaz,Brayan Osegueda,Svetlana Minakhina et al.
Eduardo Sánchez Díaz et al.
In cardiac muscle, regulation of actin polymerization at the thin filament pointed end is controlled by two structurally similar but functionally antagonistic proteins, leiomodin-2 and tropomodulin-1. Both proteins contain tropomyosin-bindi...
Ben Short
Ben Short
In a new JGP study (Thoreson et al. https://doi.org/10.1085/jgp.202413746), anatomically realistic simulations reveal how the complex architecture of rod synapses influences glutamate dynamics and postsynaptic responses. ...
Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826 [0.03%]
Suzetrigine、LTGO-33和A-887826对Nav1.8的差异性状态依赖抑制作用
Sooyeon Jo,Akie Fujita,Tomás Osorno et al.
Sooyeon Jo et al.
Nav1.8 sodium channels are expressed in pain-sensing neurons, and some Nav1.8 inhibitors significantly reduce pain in clinical trials. Several Nav1.8 inhibitors have an unusual state dependence whereby inhibition is relieved by depolarizati...
Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes [0.03%]
肌球蛋白结合蛋白C调节渗透性心肌细胞的负重肌节收缩
Kerry S McDonald,Theodore J Kalogeris,Adam B Veteto et al.
Kerry S McDonald et al.
During the ejection phase of the cardiac cycle, left ventricular (LV) cardiac myocytes undergo loaded shortening and generate power. However, few studies have measured sarcomere shortening during loaded contractions. Here, we simultaneously...
Lawrence Salkoff
Lawrence Salkoff
Studies of potassium channel evolution from the Jegla group contribute valuable insights into the evolution of complexity in electrical signaling and the conservation and repurposing of key molecular components throughout evolutionary histo...
Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels [0.03%]
栉水母和parahoxozoans独立进化出功能多样的电压门控钾通道
Benjamin T Simonson,Zhaoyang Jiang,Joseph F Ryan et al.
Benjamin T Simonson et al.
The ctenophore species Mnemiopsis leidyi is known to have a large set of voltage-gated K+ channels, but little is known about the functional diversity of these channels or their evolutionary history in other ctenophore species. Here, we sea...
Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band [0.03%]
马凡氏综合症心肌细胞显示出N2BA形式的titin过量和延长的肌节M带
Dalma Kellermayer,Cristina M Șulea,Hedvig Tordai et al.
Dalma Kellermayer et al.
Marfan syndrome (MFS) is an autosomal dominant disease caused by mutations in the gene (FBN1) of fibrillin-1, a major determinant of the extracellular matrix (ECM). Functional impairment in the cardiac left ventricle (LV) of these patients ...
Projections from ventral hippocampus to nucleus accumbens' cholinergic neurons are altered in depression [0.03%]
抑郁症患者来自腹侧海马到伏隔核的胆碱能神经元投射发生改变
Lucian Medrihan,Margarete G Knudsen,Tatiana Ferraro et al.
Lucian Medrihan et al.
The cholinergic interneurons (ChIs) of the nucleus accumbens (NAc) have a critical role in the activity of this region, specifically in the context of major depressive disorder. To understand the circuitry regulating this behavior, we sough...
Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model [0.03%]
心脏肌细胞中多尺度钙离子释放模型揭示的新型钙离子波机制
Morris Vysma,James S Welsh,Derek R Laver
Morris Vysma
Integrating cellular sarcoplasmic reticulum (SR) Ca2+ release with the known Ca2+ activation properties of RyR2s remains challenging. The sharp increase in SR Ca2+ permeability above a threshold SR luminal [Ca2+] is not reflected in RyR2 ki...
The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses [0.03%]
嵌入棒状突触的结构减缓谷氨酸扩散并影响突触反应
Wallace B Thoreson,Thomas M Bartol,Nicholas H Conoan et al.
Wallace B Thoreson et al.
Synapses of retinal rod photoreceptors involve deep invaginations occupied by second-order rod bipolar cell (RBP) and horizontal cell (HC) dendrites. Synaptic vesicles are released into this invagination at multiple sites beneath an elongat...