Coupling between an electrostatic network and the Zn2+ binding site modulates Hv1 activation [0.03%]
静电网络与Zn2+结合位点之间的偶联调节Hv1激活
Victor De La Rosa,Ashley L Bennett,Ian Scott Ramsey
Victor De La Rosa
The voltage sensor (VS) domain in Hv1 proton channels mediates a voltage-dependent and H+-selective "aqueous" conductance (GAQ) that is potently modulated by extracellular Zn2+ Although two conserved His residues are required for Zn2+ effec...
Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition [0.03%]
小鼠瞬时受体电位锚定通道A1激活与抑制的分子机制研究
Amrita Samanta,Janna Kiselar,Ruth A Pumroy et al.
Amrita Samanta et al.
Pain, though serving the beneficial function of provoking a response to dangerous situations, is an unpleasant sensory and emotional experience. Transient receptor potential ankyrin 1 (TRPA1) is a member of the transient receptor potential ...
Dimerization of the voltage-sensing phosphatase controls its voltage-sensing and catalytic activity [0.03%]
电压感觉磷酸酶的二聚作用控制其电压感觉和催化活性
Vamseedhar Rayaprolu,Perrine Royal,Karen Stengel et al.
Vamseedhar Rayaprolu et al.
Multimerization is a key characteristic of most voltage-sensing proteins. The main exception was thought to be the Ciona intestinalis voltage-sensing phosphatase (Ci-VSP). In this study, we show that multimerization is also critical for Ci-...
Christopher Miller
Christopher Miller
Miller recounts the distinct influences that Gilbert Ling and Efraim Racker had on his early career.
Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels [0.03%]
KATP通道的冷冻电子显微镜结构和通向对其动态理解的进步
Michael C Puljung
Michael C Puljung
Adenosine triphosphate (ATP)-sensitive K+ (KATP) channels are molecular sensors of cell metabolism. These hetero-octameric channels, comprising four inward rectifier K+ channel subunits (Kir6.1 or Kir6.2) and four sulfonylurea receptor (SUR...
Caitlin Sedwick
Caitlin Sedwick
New JGP study uncovers a connection between Connexin 26 fast and slow gates. © 2018 Rockefeller University Press.
Full and partial agonists evoke distinct structural changes in opening the muscle acetylcholine receptor channel [0.03%]
全长和部分激动剂通过不同的结构变化来开启肌肉乙酰胆碱受体通道
Nuriya Mukhtasimova,Steven M Sine
Nuriya Mukhtasimova
The muscle acetylcholine (ACh) receptor transduces a chemical into an electrical signal, but the efficiency of transduction, or efficacy, depends on the particular agonist. It is often presumed that full and partial agonists elicit the same...
Dana Yaffe,Lucy R Forrest,Shimon Schuldiner
Dana Yaffe
The H+-coupled vesicular monoamine transporter (VMAT) is a transporter essential for life. VMAT mediates packaging of the monoamines serotonin, dopamine, norepinephrine, and histamine from the neuronal cytoplasm into presynaptic vesicles, w...
Mitochondrial ATP synthase dimers spontaneously associate due to a long-range membrane-induced force [0.03%]
线粒体ATP合成酶二聚体会自发结合以产生远程膜作用力
Claudio Anselmi,Karen M Davies,José D Faraldo-Gómez
Claudio Anselmi
Adenosine triphosphate (ATP) synthases populate the inner membranes of mitochondria, where they produce the majority of the ATP required by the cell. From yeast to vertebrates, cryoelectron tomograms of these membranes have consistently rev...
The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels [0.03%]
Cx26半通道中综合征性耳聋突变G12R损害快速和缓慢门控功能
Isaac E García,Felipe Villanelo,Gustavo F Contreras et al.
Isaac E García et al.
Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate th...