Michael Clerx,Paul G A Volders,Gary R Mirams
Michael Clerx
Electrically active cells like cardiomyocytes show variability in their size, shape, and electrical activity. But should we expect variability in the properties of their ionic currents? In this meta-analysis, we gather and visualize measure...
Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity [0.03%]
时空分辨cMyBP-C磷酸化和低渗性对猪和人心肌原纤维中β-心脏肌球蛋白活性的影响
Matvey Pilagov,Sonette Steczina,Ateeqa Naim et al.
Matvey Pilagov et al.
β-cardiac myosin mediates cardiac muscle contraction within the sarcomere by binding to the thin filament in an ATP-powered reaction. This process is highly regulated on a beat-to-beat basis by calcium interactions with the thin filament, ...
Ben Short
Ben Short
JGP study (Han et al. https://doi.org/10.1085/jgp.202413729) reveals that glycerol storage increases the titin-based stiffness of muscle fibers, suggesting that this commonly used method should be avoided by researchers interested in the pa...
Comparative mechanistic analysis of danicamtiv and omecamtiv mecarbil's in vivo cardiac effects [0.03%]
丹尼卡米特韦和奥美卡米特韦的在体心脏作用机制比较分析
Joshua B Holmes,Julian E Stelzer
Joshua B Holmes
Danicamtiv is a second-generation myotropic sarcomere activator currently in clinical trials for treating heart failure with reduced ejection fraction. Initial clinical and preclinical studies suggest that danicamtiv improves upon the major...
Comparative Study
The Journal of general physiology. 2025 Jul 7;157(4):e202513762. DOI:10.1085/jgp.202513762 2025
Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44 [0.03%]
GJC2突变体的分子动力学模拟揭示PMLD1和SPG44的致病机制
David Gong,Jennifer L Orthmann-Murphy,Deepak Kumar et al.
David Gong et al.
GJC2 encodes connexin 47 (Cx47), a gap junction protein expressed by oligodendrocytes that forms gap junction channels (GJCs) between adjacent oligodendrocytes (or astrocytes, via heterotypic Cx47-Cx43 GJCs). Autosomal recessive mutations o...
Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism [0.03%]
运用比喻法促进钠离子通道快速失活机制研究
Peter Hull,Angelika Lampert
Peter Hull
Metaphorical language is ubiquitous throughout the life sciences, with, for example, molecules forming chains which define genetic blueprints for the development of cells and ultimately the gates in the channels forming the subject of this ...
Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini [0.03%]
侧向通道通路的破坏允许由大电导钙激活钾通道的β亚基N端介导的封闭态失活现象
Yu Zhou,Xiao-Ming Xia,Christopher J Lingle
Yu Zhou
Cytosolic N termini of several BK channel β regulatory subunits mediate rapid inactivation. However, in contrast to Kv channels, inactivation does not occur via a simple, open-channel block mechanism, but involves two steps, an association...
Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias [0.03%]
缺obscurn导致代偿性扩张型心肌病和增加的期外收缩
Josè Manuel Pioner,Enrico Pierantozzi,Raffaele Coppini et al.
Josè Manuel Pioner et al.
Obscurin is a large muscle protein whose multiple functions include providing mechanical strength to the M-band and linking the sarcomere to the sarcoplasmic reticulum. Mutations in obscurin are linked to various forms of muscle diseases. T...
Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility [0.03%]
甘油储存通过影响titin的可延展性增加肌肉纤维的被动刚度
Seong-Won Han,Justin Kolb,Gerrie P Farman et al.
Seong-Won Han et al.
To study the physiological and pathological mechanisms of muscle, it is crucial to store muscle samples in ways that preserve their properties. Glycerol is commonly used for storage, as it stabilizes muscle proteins, slows enzymatic activit...
Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons [0.03%]
缺如的胞内FGF14(iFGF14)可增强成熟海马锥体神经元的兴奋性
Joseph L Ransdell,Yarimar Carrasquillo,Marie K Bosch et al.
Joseph L Ransdell et al.
Mutations in FGF14, which encodes intracellular fibroblast growth factor 14 (iFGF14), have been linked to spinocerebellar ataxia type 27 (SCA27), a multisystem disorder associated with deficits in motor coordination and cognitive function. ...