The origins of oscillations [0.03%]
振荡的起源
Ben Short
Ben Short
JGP study (Horie et al. https://doi.org/10.1085/jgp.202413749) explains why mice lacking TRPM1 exhibit oscillatory firing of their retinal ganglion cells, and suggests that the same mechanism causes similar oscillations in other outer retin...
A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness [0.03%]
小鼠视网膜神经节细胞在夜盲模型中病理振荡的机制研究
Sho Horie,Konan Sakuta,Keigo Tada et al.
Sho Horie et al.
TRPM1 channels, regulated by mGluR6 at the dendrites of retinal ON bipolar cells (BCs), play a crucial role in visual signal transduction. Both Trpm1 knockout (KO) and mGluR6 KO mice are models of congenital stationary night blindness with ...
SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1 [0.03%]
SUMOylation和ATR1变异汇聚破坏Kir2.1的PIP2依赖性门控功能
Aishwarya Chandrashekar,Yu Xu,Xinyi Ma et al.
Aishwarya Chandrashekar et al.
Precise control of Kir2.1 channel gating is essential for maintaining membrane potential and enabling repolarization in excitable cells. Disruption of Kir2.1 function can cause Andersen-Tawil syndrome type 1 (ATS1), a multisystem channelopa...
Voltage-gated sodium channels: Mechanisms, disease, and a growing research community [0.03%]
电压门控钠通道：机制、疾病及日益增长的研究人群
Hugues Abriel,Angelika Lampert
Hugues Abriel
In this special issue of the Journal of General Physiology (JGP), we bring together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, and structure-function analysis of voltage-gated sodium (N...
Cortical spreading depression dynamics are altered by topical D2 receptor ligands [0.03%]
D2受体配体经皮给药可改变皮层扩散抑制的动态过程
Sonia Carolina Guerrero Prieto,Michael Cabrera Baez,Rubem Carlos Araújo Guedes
Sonia Carolina Guerrero Prieto
Cortical spreading depression (CSD) is a transient wave of neuronal and glial depolarization that propagates slowly through the cerebral cortex and is implicated in neurological events such as migraine aura. While glutamate, GABA, and serot...
Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice [0.03%]
Cantú综合征小鼠中由SUR2-但不是Kir6.1介导的内在性肌疲劳增加模型的研究
Rosa Scala,Maya Mukadam,Yuezhou Chen et al.
Rosa Scala et al.
Cantu syndrome (CS) is a rare disease caused by gain-of-function (GOF) mutations of Kir6.1 or SUR2 subunits of ATP-sensitive potassium (KATP) channels. CS patients with SUR2 and Kir6.1 variants display a similar constellation of symptoms, i...
PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating [0.03%]
PIP2驱动的细胞质区运动与Kir2通道门控相耦合
Eva-Maria Zangerl-Plessl,Anna Stary-Weinzinger,Colin G Nichols et al.
Eva-Maria Zangerl-Plessl et al.
Inwardly rectifying potassium (Kir) channel activity is important in the control of membrane potentials in both excitable and non-excitable cells and is regulated through various ligands, including specific membrane lipids. Phosphatidyl-4,5...
Adriano Senatore,Tatiana D Mayorova,Luis A Yañez-Guerra et al.
Adriano Senatore et al.
The sodium leak channel NALCN, a key regulator of neuronal excitability, associates with three ancillary subunits that are critical for its function: a subunit called FAM155, which interacts with the extracellular regions of the channel, an...
Investigating the role of the I-II linker in Nav1.5 channel function [0.03%]
I-II连接子在Nav1.5通道功能中的作用研究
Emily Wagner,Martina Marras,Shashi Kumar et al.
Emily Wagner et al.
The cardiac voltage-gated sodium channel, Nav1.5, initiates the cardiac action potential. Its dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. The functional Nav1.5 core consists of four homologous repeats (I...
Shane R Nelson
Shane R Nelson
Cardiac contractility is driven by shortening of ∼2-μm-long, macromolecular assemblies known as sarcomeres. During contraction, the motor protein myosin binds to, and exerts force upon actin filaments, utilizing energy from the hydrolysis...