Subtype-selective targeting of NMDA receptors-A potent new compound emerges [0.03%]
选择性靶向NMDA受体亚型——一种新的有效化合物出现
Hiro Furukawa
Hiro Furukawa
Subtype-selective modulation of N-methyl-D-aspartate receptors (NMDARs) remains a major goal in neuropharmacology, with the potential to advance basic research and enable targeted therapies for disorders involving dysregulated glutamatergic...
Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel [0.03%]
羧基末端结构区的错义突变改变心脏钠通道的特定属性
Akshay Sharma,Christopher Marra,Nomon Mohammad et al.
Akshay Sharma et al.
Voltage-gated sodium channels undergo reversible voltage/time-dependent transitions from closed to open and inactivated states. The voltage setpoints and efficiency of cardiac sodium channel Nav1.5 state transitions are crucial for tuning t...
β2 and β3a regulatory subunits can coassemble in the same BK channels [0.03%]
β2和β3a调节亚基可以共同组装在同一BK通道中
Yu Zhou,Vivian Gonzalez-Perez,Xiao-Ming Xia et al.
Yu Zhou et al.
Ca2+- and voltage-activated BK-type K+ channels are influenced profoundly by associated regulatory subunits, including β subunits (Kcnmb1-4; β1-β4). Although overlap in expression of different BK β subunits occurs in native tissues, whe...
Myosin-binding protein H-like nonsense variants exhibit impaired sarcomere incorporation and alter contractility [0.03%]
肌球蛋白结合蛋白H假无效变异体表现出嵌入辅肌丝功能受损和改变收缩性
Alejandro Alvarez-Arce,Geena E Fritzmann,Hope V Burnham et al.
Alejandro Alvarez-Arce et al.
Heart function depends on cardiomyocyte contractile apparatus and proper sarcomere protein expression. Variants in sarcomere genes cause inherited forms of cardiomyopathy and arrhythmias, including atrial fibrillation. Recently, a sarcomere...
Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue [0.03%]
通过操纵单赖氨酸残基对离子通道进行光学控制以调控PI（4,5）P2敏感性
Junxian Zhou,Rizki Tsari Andriani,Natsuki Mizutani et al.
Junxian Zhou et al.
Polyphosphoinositides (PPIns) are essential components of membrane lipids and play crucial roles in cell signaling in eukaryotes. Phosphatidylinositol4,5-bisphosphate (PI(4,5)P2) is a species of PPIns enriched in the plasma membrane and reg...
Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry [0.03%]
激活的斑马鱼肌肉纤维中的锰淬灭并非由于钙库操作型钙内流所致
Francisco Jaque-Fernandez,Léa Demesmay,Romane Idoux et al.
Francisco Jaque-Fernandez et al.
In mammalian skeletal muscle fibers, transmembrane Ca2+ influx is known to occur at rest and to increase in response to depolarization. In parallel to the well-identified dihydropyridine receptor (DHPR) pathway underlying this depolarizatio...
Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit [0.03%]
钙通道辅助亚基β3调节CaV1.2电压感受结构
Daniela De Giorgis,Guido Mellado,Jose Antonio Garate et al.
Daniela De Giorgis et al.
High voltage-activated (HVA) calcium channels (CaV) have four homologous but nonidentical repeats encompassing a voltage-sensing domain (VSD) and a quarter of the pore domain (PD). HVA can be modulated by at least two accessory subunits α2...
Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture [0.03%]
水凝胶嵌入肌纤维提高细胞活力并在体外长期培养中保持收缩功能
Leander A Vonk,Osman Esen,Daan Hoomoedt et al.
Leander A Vonk et al.
Ex vivo culture of isolated muscle fibers can serve as an important model for in vitro research on mature skeletal muscle fibers. Nevertheless, this model has limitations for long-term studies due to structural loss and dedifferentiation fo...
Correction: The calcium-binding protein S100A1 binds to titin's N2A insertion sequence in a pH-dependent manner [0.03%]
题目校正：钙结合蛋白S100A1以pH依赖性方式与titin的N2A插序序列结合
Sabrina I Apel,Emily Schaffter,Nicholas Melisi et al.
Sabrina I Apel et al.
Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction [0.03%]
两名由于酪氨酸66丝氨酸变异导致小纤维功能障碍的患者其NaV1.9通道活性改变
Noortje W M van den Braak,Samuel Kuehs,Greta Z Peschke et al.
Noortje W M van den Braak et al.
Pain perception is a complex experience, the initiation of which is mediated, among others, by voltage-gated sodium channels. Pathogenic variants in the sodium channel gene SCN11A encoding for NaV1.9 have been associated with various pain l...