Ben Short
Ben Short
JGP study (Avilés et al. https://doi.org/10.1085/jgp.202413642) reveals that visual perception of high-frequency flickers requires signaling by the tissue polarity protein FAT3 in retinal bipolar cells. ...
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease [0.03%]
α-actinin同种型的结构和功能见解及其在心血管疾病中的影响
Maya Noureddine,Halina Mikolajek,Neil V Morgan et al.
Maya Noureddine et al.
α-actinin (ACTN) is a pivotal member of the actin-binding protein family, crucial for the anchoring and organization of actin filaments within the cytoskeleton. Four isoforms of α-actinin exist: two non-muscle isoforms (ACTN1 and ACTN4) p...
Andrew L Harris
Andrew L Harris
Gupta et al. (https://doi.org/10.1085/jgp.202413676) reconcile a disconnect between structural and functional data regarding stoichiometry of PANX1 channels and provide new insights about channel activation. ...
ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells [0.03%]
小鼠视网膜双极细胞中FAT3信号通路对高频闪烁引起的ERG反应是必需的
Evelyn C Avilés,Sean K Wang,Sarina Patel et al.
Evelyn C Avilés et al.
Vision is initiated by the reception of light by photoreceptors and subsequent processing via downstream retinal neurons. Proper circuit organization depends on the multifunctional tissue polarity protein FAT3, which is required for amacrin...
Brent D Foy,Chris Dupont,Phillip V Walker nd et al.
Brent D Foy et al.
Patients with periodic paralysis have attacks of weakness precipitated by depolarization of muscle. Each form of periodic paralysis is associated with unique changes in serum K+ during attacks of weakness. In hypokalemic periodic paralysis ...
JGP in 2025 [0.03%]
迈向2025年的JGP
David Eisner
David Eisner
Matthew Carter Childers
Matthew Carter Childers
Phan and Fitzsimons (https://doi.org/10.1085/jgp.202413582) develop a new mathematical model of muscle contraction that explores cooperative mechanisms in small (murine) and large (porcine) myocardium. ...
Worawan B Limpitikul,Ivy E Dick
Worawan B Limpitikul
Voltage-gated Ca2+ channels (VGCCs) are highly expressed throughout numerous biological systems and play critical roles in synaptic transmission, cardiac excitation, and muscle contraction. To perform these various functions, VGCCs are high...
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium [0.03%]
哺乳动物心肌细丝邻近协同作用的模型式效应
Tuan A Phan,Daniel P Fitzsimons
Tuan A Phan
The mechanisms underlying cooperative activation and inactivation of myocardial force extend from local, near-neighbor interactions involving troponin-tropomyosin regulatory units (RU) and crossbridges (XB) to more global interactions acros...
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders [0.03%]
电压门控钠离子通道突变在心血管疾病中作用的理解
Christian Jorgensen
Christian Jorgensen
Elhanafy et al. used Molecular Dynamics simulations and electrophysiology to show how identical mutations in the volgage sending domain of sodium channels can yield differential functional effects. ...