Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere [0.03%]
心脏肌球蛋白结合蛋白-C的翻译后修饰：精细调节肌小节的机制
Angela C Greenman,Willem de Lange,J Carter Ralphe
Angela C Greenman
Since the discovery of the cardiac isoform of myosin-binding protein-C (cMyBP-C), there has been continued interest in how cMyBP-C impacts cardiac function in both health and disease. cMyBP-C is a regulatory protein in the sarcomere that co...
Putative RNA editing of a nicotinic receptor increases acetylcholine sensitivity [0.03%]
推测的烟碱型受体RNA编辑提高了乙酰胆碱敏感性
Cecilia M Borghese,Ying Lu,Edward J Bertaccini et al.
Cecilia M Borghese et al.
Regulation of the agonist sensitivity of neurotransmitter receptors is critical for proper functioning of neuronal circuits and is, therefore, conserved across evolutionary time. Mutations that alter agonist sensitivity are often pathologic...
Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel [0.03%]
电压门控钠离子通道的锂离子选择性结构功能分析
Yuki K Maeda,Kentaro Kojima,Tomoe Y Nakamura et al.
Yuki K Maeda et al.
Voltage-gated sodium channels (Navs) selectively conduct Na+ to generate action potentials. Na+ permeates Navs with significantly higher efficiency than many other cations, but Li+ can also permeate Navs to an extent comparable with Na+. Li...
JGP in 2026 [0.03%]
2026年的JGP赛程
David Eisner
David Eisner
Molecular dynamics analyses of CLDN15 pore size and charge selectivity [0.03%]
CLDN15孔大小和电荷选择性的分子动力学分析
Sarah McGuinness,Pan Li,Ye Li et al.
Sarah McGuinness et al.
Claudin-15 (CLDN15) molecules form channels that directly regulate cation and water transport. In the gastrointestinal tract, this transport indirectly impacts nutrient absorption. However, the mechanisms governing ion transport through the...
Ben Short
Ben Short
JGP study (Dapino and Curti. https://doi.org/10.1085/jgp.202513883) reveals that the D-type K+ current regulates coincidence detection by shaping electrical transmission between pairs of MesV neurons. ...
Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence [0.03%]
prepulse 通过激活通道的移动产生并需要完整的失活序列来实现蜜蜂CaV4通道的促进作用
Thierry Cens,Matthieu Rousset,Claudine Menard et al.
Thierry Cens et al.
The recently characterized honeybee CaV4 channel is a high-voltage-activated Ca2+ channel ortholog to the DSC1 channel identified in Drosophila. While sequence similarities to NaV channels are obvious, permeation properties and current kine...
AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia [0.03%]
AMPK介导的HCN4通道磷酸化参与了与年龄相关的心率内在减慢现象
Luca M G Palloni,Nicole Sarno,Caterina Azzoni et al.
Luca M G Palloni et al.
The regulation of the hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) channels in pacemaker myocytes is essential for maintaining physiological cardiac rhythm. HCN4 dysfunctional behavior is among the major factors contributing...
Coincidence detection supported by electrical synapses is shaped by the D-type K+ current [0.03%]
D型钾电流对电突触介导的偶然检测的影响
Antonella Dapino,Sebastián Curti
Antonella Dapino
Electrical synapses mediated by gap junctions are widespread in the mammalian brain, playing essential roles in neural circuit function. Beyond their role synchronizing neuronal activity, they also support complex computations such as coinc...
A primer on the methods of skeletal and cardiac muscle mechanics using permeabilized preparations [0.03%]
鬼笔环肽固定肌丝条件下骨骼肌和心肌力学方法综述
Anthony L Hessel,Katelyn M Manross,Matthew M Borkowski et al.
Anthony L Hessel et al.
Permeabilized muscle fibers have a chemically disturbed sarcolemma that allows for the mixing of the extra- and intracellular environments and is important for a large variety of experimental methods. The experimental tools and skillsets us...