Ben Short
Ben Short
JGP study (Handlin et al. https://doi.org/10.1085/jgp.202513925) provides new mechanistic insights into the cholesterol-dependent modulation of pain sensation by DRG neurons. ...
Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane [0.03%]
家兔 apex 耳蜗 Corti 器官和基底膜的独特机械响应特征
George W S Burwood,Tianying Ren,Edward V Porsov et al.
George W S Burwood et al.
Upon acoustic stimulation of the mammalian cochlea, a travelling wave will move in a base-to-apex direction, peaking close to the resonant place of the basilar membrane. A gradient of different resonances along the basilar membrane gives ri...
Missense mutation causes multiple defects in Nav1.4 channel gating and leads to an SCN4A-associated overlap phenotype [0.03%]
错义突变引起Nav1.4通道多种门控缺陷并导致SCN4A相关重叠型周期性瘫痪症状
Tatiana B Tikhonova,Artem A Sharkov,Aysylu F Murtazina et al.
Tatiana B Tikhonova et al.
Mutations in SCN4A gene encoding the skeletal muscle-type voltage-gated sodium channel Nav1.4 are known to cause neuromuscular disorders. Here, we report a previously undescribed variant affecting the DIII-IV cytoplasmic linker, which is a ...
Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels [0.03%]
结合线弹性网络模型和线性响应理论研究HCN通道中变构调节的全局动态机制
Magnus Behringer,Jan Krumbach,Alessandro Porro et al.
Magnus Behringer et al.
Hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN channels) play important regulatory roles in the heart and the brain. At the core of their physiological functions is an activation by negative membrane potential and ...
Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations [0.03%]
糖尿病条件下缝隙连接偶联降低不会导致功能β细胞亚群的丧失
Claire H Levitt,Dominic Isaacs,Maria S Hansen et al.
Claire H Levitt et al.
Within the islets of Langerhans, gap junction coupling is important for synchronizing oscillatory free-calcium activity ([Ca2+]) and regulating pulsatile insulin release. In islets from multiple models of diabetes, gap junction coupling is ...
Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles [0.03%]
窦房结中的ATP微域与钙离子时间相互映射并制定能量层级和区域起搏器的作用模式
Manuel F Muñoz,Collin Matsumoto,Paula Rhana et al.
Manuel F Muñoz et al.
Pacemaker cells of the sinoatrial (SA) node fire spontaneously and continuously under normal conditions, sustaining a high energetic cost with every heartbeat. How they meet this demand has remained poorly understood. Using genetically enco...
Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons [0.03%]
胆固醇通过序列膜重塑在幼稚和神经病理性DRG神经元中特异性调节HCN通道
Lucas J Handlin,Clémence Gieré,Nicolas L A Dumaire et al.
Lucas J Handlin et al.
Cholesterol, abundantly present in distinct plasma membrane pools, is a critical modulator of ion channel function, including hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that regulate the excitability of dorsal root g...
Titin's P-zone domains A164-167 are essential for thick filament structural arrangement [0.03%]
题标：蛋白titin的P区结构域A164-167对肌原纤维粗丝结构排列是必需的
Catherine Hoover Browne,Seong-Won Han,Gerrie P Farman et al.
Catherine Hoover Browne et al.
The sarcomeric protein titin plays a central role in thick filament structure and function through its modular A-band domains, including the understudied P-zone, which links the C-zone to the M-band. To investigate the first four domains of...
Lisa Schmidt,Wojciech Kopec
Lisa Schmidt
Lopez-Mateos et al. show that AlphaFold 2 can generate structural ensembles of NaV channels and that β-subunits and calmodulin reshape these ensembles, while emphasizing that these are testable structural hypotheses, not actual thermodynam...
Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen [0.03%]
光动力产生的单线态氧开启视杆细胞CNG通道
Gaogao He,Xiaoxi Li,Yanlin Huang et al.
Gaogao He et al.
Molecular oxygen exists in three electronic states: the triplet ground state and two singlet (1O2) excited states. Under physiological conditions, 1O2 can be produced either through photodynamic processes, which require light, photosensitiz...