Null method to estimate the maximal PA at subsaturating concentrations of agonist [0.03%]
利用激动剂亚饱和浓度下的零法估计最大配体占用率
Allison L Germann,Spencer R Pierce,Joe Henry Steinbach et al.
Allison L Germann et al.
The maximal probability of being in an active state (PA,max) is a measure of gating efficacy for a given agonist acting on a given receptor channel. In macroscopic electrophysiological recordings, PA,max is typically estimated by comparing ...
Regulation of NMDAR activation efficiency by environmental factors and subunit composition [0.03%]
环境因素和亚基组成对NMDAR激活效率的调节作用
Miaomiao He,Lonnie P Wollmuth
Miaomiao He
NMDA receptors (NMDAR) convert the major excitatory neurotransmitter glutamate into a synaptic signal. A key question is how efficiently the ion channel opens in response to the rapid exposure to presynaptic glutamate release. Here, we appl...
Vidya Murthy,Josh E Baker
Vidya Murthy
Accurate models of muscle contraction are necessary for understanding muscle performance and the molecular modifications that enhance it (e.g., therapeutics, posttranslational modifications, etc.). As a thermal system containing millions of...
Ben Short
Ben Short
JGP study (Steinz et al. https://doi.org/10.1085/jgp.202313515) reveals that oxidative stress can induce stable posttranslational modifications of RyR1 that increase the channel's open probability and could therefore disrupt muscle contract...
Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae [0.03%]
霍乱弧菌谷氨酸特异性的TAXI TRAP结合蛋白的结构和选择性
Joseph F S Davies,Andrew Daab,Nicholas Massouh et al.
Joseph F S Davies et al.
Tripartite ATP-independent periplasmic (TRAP) transporters are widespread in prokaryotes and are responsible for the transport of a variety of different ligands, primarily organic acids. TRAP transporters can be divided into two subclasses;...
Correction: Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle [0.03%]
关于发育脊椎动物快肌纤维肌球蛋白结合蛋白H功能作用的更正论文
Andrew F Mead,Neil B Wood,Shane R Nelson et al.
Andrew F Mead et al.
Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1 [0.03%]
运动训练可通过DRP1减少心肌梗死后缺血再灌注损伤中的线粒体碎裂
Mathilde Dubois,Florian Pallot,Maxime Gouin-Gravezat et al.
Mathilde Dubois et al.
Mitochondrial fission is a key trigger of cardiac ischemia-reperfusion injuries (IR). Exercise training is an efficient cardioprotective strategy, but its impact on mitochondrial fragmentation during IR remains unknown. Using isolated rat h...
Stable oxidative posttranslational modifications alter the gating properties of RyR1 [0.03%]
稳定的氧化型翻译后修饰改变了RyR1的门控特性
Maarten M Steinz,Nicole Beard,Emily Shorter et al.
Maarten M Steinz et al.
The ryanodine receptor type 1 (RyR1) is a Ca2+ release channel that regulates skeletal muscle contraction by controlling Ca2+ release from the sarcoplasmic reticulum (SR). Posttranslational modifications (PTMs) of RyR1, such as phosphorylat...
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors [0.03%]
Piezo2与专门的胃肠道上皮机械感受器中的E-钙粘蛋白相互作用
Arnaldo Mercado-Perez,Jeric P Hernandez,Yaroslav Fedyshyn et al.
Arnaldo Mercado-Perez et al.
Piezo2 is a mechanically gated ion channel most commonly expressed by specialized mechanoreceptors, such as the enteroendocrine cells (EECs) of the gastrointestinal epithelium. A subpopulation of EECs expresses Piezo2 and functionally resem...
David Y Barefield
David Y Barefield
Decades of research into striated muscle have provided a robust understanding of the structure and function of the sarcomere and its protein constituents. However, a handful of sarcomere proteins remain that have had little to no functional...