Worawan B Limpitikul,Ivy E Dick
Worawan B Limpitikul
Voltage-gated Ca2+ channels (VGCCs) are highly expressed throughout numerous biological systems and play critical roles in synaptic transmission, cardiac excitation, and muscle contraction. To perform these various functions, VGCCs are high...
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium [0.03%]
哺乳动物心肌细丝邻近协同作用的模型式效应
Tuan A Phan,Daniel P Fitzsimons
Tuan A Phan
The mechanisms underlying cooperative activation and inactivation of myocardial force extend from local, near-neighbor interactions involving troponin-tropomyosin regulatory units (RU) and crossbridges (XB) to more global interactions acros...
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders [0.03%]
电压门控钠离子通道突变在心血管疾病中作用的理解
Christian Jorgensen
Christian Jorgensen
Elhanafy et al. used Molecular Dynamics simulations and electrophysiology to show how identical mutations in the volgage sending domain of sodium channels can yield differential functional effects. ...
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials [0.03%]
疼痛感受器钠通道塑形亚阈值相位、动作电位去极化上升相位和次级波峰
Phil Alexander Köster,Enrico Leipold,Jenny Tigerholm et al.
Phil Alexander Köster et al.
Voltage-gated sodium channels (VGSCs) in the peripheral nervous system shape action potentials (APs) and thereby support the detection of sensory stimuli. Most of the nine mammalian VGSC subtypes are expressed in nociceptors, but predominan...
The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels [0.03%]
等效 gating-电荷突变在电压门控钠通道中的不同影响
Eslam Elhanafy,Amin Akbari Ahangar,Rebecca Roth et al.
Eslam Elhanafy et al.
Voltage-gated sodium (Nav) channels are pivotal for cellular signaling, and mutations in Nav channels can lead to excitability disorders in cardiac, muscular, and neural tissues. A major cluster of pathological mutations localizes in the vo...
Correction: How could simulations elucidate Nav1.5 channel blockers mechanism? [0.03%]
关于模拟如何阐明Nav1.5通道阻滞剂的作用机制的更正文章
Tanadet Pipatpolkai
Tanadet Pipatpolkai
Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore [0.03%]
药物在Nav1.5心脏钠通道孔道内的多种结合模式和进入途径
Elaine Tao,Ben Corry
Elaine Tao
Small molecule inhibitors of the sodium channel are common pharmacological agents used to treat a variety of cardiac and nervous system pathologies. They act on the channel via binding within the pore to directly block the sodium conduction...
Tanadet Pipatpolkai
Tanadet Pipatpolkai
Tao and Corry used metadynamics, an enhanced sampling method to identify and classify Nav channel blockers. © 2025 Pipatpolkai.
The calcium-binding protein S100A1 binds to titin's N2A insertion sequence in a pH-dependent manner [0.03%]
钙结合蛋白S100A1以pH依赖性方式与Titin的N2A插入序列结合
Sabrina I Apel,Emily Schaffter,Nicholas Melisi et al.
Sabrina I Apel et al.
Titin is the third contractile filament in the sarcomere, and it plays a critical role in sarcomere integrity and both passive and active tension. Unlike the thick and thin filaments, which are polymers of myosin and actin, respectively, ti...
ALLIN: A tool for annotation of a protein alignment combined with structural visualization [0.03%]
ALLIN：一个结合结构可视化的蛋白质多重序列对齐注释工具
Alessandra Picollo,Michael Pusch
Alessandra Picollo
The physiological, functional, and structural properties of proteins and their pathogenic variants can be summarized using many tools. The information relating to a single protein is often spread among different sources requiring different ...