Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle [0.03%]
双联刺激增加骨骼肌中troponin C对Ca2+的结合以确保快速产生力
Anthony J Bakker,Tanya R Cully,Catherine D Wingate et al.
Anthony J Bakker et al.
Fast-twitch skeletal muscle fibers are often exposed to motor neuron double discharges (≥200 Hz), which markedly increase both the rate of contraction and the magnitude of the resulting force responses. However, the mechanism responsible f...
Gating ring strengthens marriage of BK channel voltage sensing to pore opening [0.03%]
gates环增强BK通道电压感应与孔开启之间的结合力
Caitlin Sedwick
Caitlin Sedwick
A new JGP study shows that the gating ring helps the voltage-sensing domain open the BK channel's pore. © 2017 Rockefeller University Press.
Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels [0.03%]
细胞间门控环的删除减少了BK通道门和电压传感器的耦合
Guohui Zhang,Yanyan Geng,Yakang Jin et al.
Guohui Zhang et al.
Large conductance Ca2+-activated K+ channels (BK channels) gate open in response to both membrane voltage and intracellular Ca2+ The channel is formed by a central pore-gate domain (PGD), which spans the membrane, plus transmembrane voltage...
Che-Wei Chang,Chung-Wei Chiang,Meyer B Jackson
Che-Wei Chang
Ca2+-triggered exocytosis functions broadly in the secretion of chemical signals, enabling neurons to release neurotransmitters and endocrine cells to release hormones. The biological demands on this process can vary enormously. Although sy...
Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells [0.03%]
哺乳动物视网膜节细胞中产生瞬时和持续光反应的机制
Xiwu Zhao,Aaron N Reifler,Melanie M Schroeder et al.
Xiwu Zhao et al.
Retinal neurons use sustained and transient light responses to encode visual stimuli of different frequency ranges, but the underlying mechanisms remain poorly understood. In particular, although earlier studies in retinal ganglion cells (R...
Sharona E Gordon
Sharona E Gordon
Amid a difficult year for science and scientists, The Journal of General Physiology is thriving and gearing up for its 100th anniversary celebrations. ©...
The intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation [0.03%]
内在配体环核苷酸结合同源结构域促进KCNH通道激活
Yaxian Zhao,Marcel P Goldschen-Ohm,João H Morais-Cabral et al.
Yaxian Zhao et al.
Channels in the ether-à-go-go or KCNH family of potassium channels are characterized by a conserved, C-terminal domain with homology to cyclic nucleotide-binding homology domains (CNBhDs). Instead of cyclic nucleotides, two amino acid resi...
Caitlin Sedwick
Caitlin Sedwick
A new JGP study shows how a disease-causing mutation in RyR2 dramatically alters channel behavior. © 2017 Rockefeller University Press.
Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2 [0.03%]
识别TRPM2的NUDT9同源结构域中的cADPr结合口袋
Peilin Yu,Xiwen Xue,Jianmin Zhang et al.
Peilin Yu et al.
Activation of the transient receptor potential melastatin 2 (TRPM2) channel occurs during the response to oxidative stress under physiological conditions as well as in pathological processes such as ischemia and diabetes. Accumulating evide...
Haidun Yan,Chaojian Wang,Steven O Marx et al.
Haidun Yan et al.
Increased "persistent" current, caused by delayed inactivation, through voltage-gated Na+ (NaV) channels leads to cardiac arrhythmias or epilepsy. The underlying molecular contributors to these inactivation defects are poorly understood. He...