In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel [0.03%]
人体TPC2阳离子通道门控及选择性机制的计算机模拟特征分析
Alp Tegin Şahin,Ulrich Zachariae
Alp Tegin Şahin
Two-pore channels (TPCs) are twofold symmetric endolysosomal cation channels forming important drug targets, especially for antiviral drugs. They are activated by calcium, ligand binding, and membrane voltage, and to date, they are the only...
Michael L Jennings
Michael L Jennings
The article by Lewis et al. (https://doi.org/10.1085/jgp.202413709) in this issue of JGP describes the use of single-molecule fluorescence polarization microscopy to obtain estimates of all the rate constants for transitions in the catalyti...
Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy [0.03%]
荧光偏振显微镜检测AdiC转运蛋白的构象动力学
John H Lewis,Yufeng Zhou,Zhe Lu
John H Lewis
To understand the mechanism underlying the ability of individual AdiC molecules to transport arginine and agmatine, we used a recently developed high-resolution single-molecule fluorescence-polarization microscopy method to investigate conf...
Ben Short
Ben Short
JGP study (Avilés et al. https://doi.org/10.1085/jgp.202413642) reveals that visual perception of high-frequency flickers requires signaling by the tissue polarity protein FAT3 in retinal bipolar cells. ...
Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease [0.03%]
α-actinin同种型的结构和功能见解及其在心血管疾病中的影响
Maya Noureddine,Halina Mikolajek,Neil V Morgan et al.
Maya Noureddine et al.
α-actinin (ACTN) is a pivotal member of the actin-binding protein family, crucial for the anchoring and organization of actin filaments within the cytoskeleton. Four isoforms of α-actinin exist: two non-muscle isoforms (ACTN1 and ACTN4) p...
Andrew L Harris
Andrew L Harris
Gupta et al. (https://doi.org/10.1085/jgp.202413676) reconcile a disconnect between structural and functional data regarding stoichiometry of PANX1 channels and provide new insights about channel activation. ...
ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells [0.03%]
小鼠视网膜双极细胞中FAT3信号通路对高频闪烁引起的ERG反应是必需的
Evelyn C Avilés,Sean K Wang,Sarina Patel et al.
Evelyn C Avilés et al.
Vision is initiated by the reception of light by photoreceptors and subsequent processing via downstream retinal neurons. Proper circuit organization depends on the multifunctional tissue polarity protein FAT3, which is required for amacrin...
Brent D Foy,Chris Dupont,Phillip V Walker nd et al.
Brent D Foy et al.
Patients with periodic paralysis have attacks of weakness precipitated by depolarization of muscle. Each form of periodic paralysis is associated with unique changes in serum K+ during attacks of weakness. In hypokalemic periodic paralysis ...
JGP in 2025 [0.03%]
迈向2025年的JGP
David Eisner
David Eisner
Matthew Carter Childers
Matthew Carter Childers
Phan and Fitzsimons (https://doi.org/10.1085/jgp.202413582) develop a new mathematical model of muscle contraction that explores cooperative mechanisms in small (murine) and large (porcine) myocardium. ...