What to Eat for Cancer Prevention: The Total Dietary Pattern as a Combination Treatment for Prevention [0.03%]
吃什么可以预防癌症？总体饮食模式是预防治疗的综合方法
Yiwen Zhang,Edward L Giovannucci
Yiwen Zhang
Over the past 2 decades, the search for dietary factors for developing cancer prevention guidelines has led to a significant expansion in the study of dietary patterns and their relation to cancer. Dietary patterns, which consider the types...
Jiangjiang Zhu
Jiangjiang Zhu
Cancer has been marked by metabolic irregularities that fuel various aggressive activities such as rapid cell proliferation, evasion of the immune system, and spread to distant organs. Therefore, exploiting cancer metabolism for diagnosis, ...
The Role of Circulating Tumor DNA for Management of Patients With Rectal Cancer: Challenges and Opportunities [0.03%]
循环肿瘤DNA在结直肠癌患者管理中的作用：机遇与挑战
Ibrahim Halil Sahin,Rami Yanes,Turcin Saridogan et al.
Ibrahim Halil Sahin et al.
Recently, organ preservation with total neoadjuvant therapy resulted in substantial progress in the management of locally advanced rectal cancer (LARC). The PROSPECT trial showed noninferiority of de-escalation of radiotherapy for patients ...
Michael P Dykstra,Smith Apisarnthanarax,George Poultsides et al.
Michael P Dykstra et al.
The oligometastatic disease state, defined as a cancer with 5 or fewer sites of metastasis, is a therapeutic opportunity to improve oncologic outcomes. Colorectal cancer (CRC) was among the first for which oligometastatic treatment was used...
Sean R Miller,Daniel T Chang
Sean R Miller
Colorectal cancer is one of the most common malignancies in the United States as well as a leading cause of cancer-related death. Upward of 30% of patients ultimately develop metastatic disease, most commonly to the liver and lung. Untreate...
Samuel N Regan,Samantha Hendren,John C Krauss et al.
Samuel N Regan et al.
Up to 10% of patients with locally advanced rectal cancer will experience locoregional recurrence. In the setting of prior surgery and often radiation and chemotherapy, these represent uniquely challenging cases. When feasible, surgical res...
Point/Counterpoint #2: Current Clinical Considerations With Nonoperative Management of Rectal Cancer [0.03%]
rectal癌非手术治疗的当前临床考虑因素
Greeshma Rajeev-Kumar,Rohan R Katipally,Shen Li et al.
Greeshma Rajeev-Kumar et al.
Locally advanced rectal cancer has historically been treated with multimodal therapy consisting of radiation therapy, chemotherapy, and total mesorectal excision. However, recent prospective trials and registry studies have demonstrated sim...
Point/Counterpoint #1: Chemotherapy Alone Is a Sufficient Preoperative Treatment for Rectal cancer [0.03%]
焦点讨论一：化学治疗可作为直肠癌术前的足够治疗手段吗
Abhishek Kumar,Manisha Palta,Jingquan Jia
Abhishek Kumar
For decades, the standard neoadjuvant therapy regimen for locally advanced rectal cancer consisted of chemoradiation, surgical resection, and consideration of adjuvant systemic therapy. Additional data have emerged suggesting neoadjuvant sy...