The Role of Circulating Tumor DNA (ctDNA) in the Treatment of Human Papilloma Virus-positive (HPV+) Oropharyngeal Squamous Cell Carcinoma [0.03%]
循环肿瘤DNA（ctDNA）在人类乳头瘤病毒阳性（HPV+）口咽鳞癌治疗中的作用
Joshua Y Qian,Linda Chen,Winston Wong et al.
Joshua Y Qian et al.
Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) presents a favorable prognosis compared with its HPV-negative counterpart, prompting interest in treatment de-escalation to reduce toxicity. However, attempts...
Advances in Systemic and Immunotherapies for Human Papillomavirus-Mediated Oropharyngeal Cancers [0.03%]
人类乳头瘤病毒介导的口咽癌的系统性和免疫疗法进展
Niema B Razavian
Niema B Razavian
This review highlights recent advances in systemic and immunotherapy for patients with HPV-mediated oropharynx cancer. Over the last 20 years, therapies have evolved from cytotoxic agents alone to those that target mechanisms of treatment r...
The Change in Paradigm for Surgical Management of HPV-positive Oropharynx Cancer [0.03%]
人乳头瘤病毒阳性型口咽癌手术治疗理念的改变
Daniel W Scholfield,Ian Ganly
Daniel W Scholfield
Traditional surgical approaches to all oropharyngeal cancer included open surgery via mandibulotomy or mandibular swing procedures-extensive surgery that often led to tracheostomy, gastrostomy tube dependence, and prolonged hospital stay. A...
Fan Zhu,Musaddiq Awan
Fan Zhu
HPV+ oropharyngeal cancer represents a unique disease entity in the realm of head and neck cancer with distinct incidence and prevalence, pathogenesis, and treatment outcome. Management of this disease needs to be personalized in considerat...
Anika Patel,Anna Lee
Anika Patel
Standard of care for locoregionally advanced HPV-positive OPSCC is definitive chemoradiation with doses up to 70 Gy and concurrent cisplatin. Radiation techniques have evolved considerably from 3D conformal radiotherapy (3D CRT) to the now ...
Abel Martel-Martel,Krishna M Sinha,Eduardo Vilar
Abel Martel-Martel
Recent advances in cancer immunotherapy have established neoantigen-based vaccines as a promising approach to cancer prevention. Unlike tumor-associated antigens, neoantigens originate exclusively from somatic mutations, thus enabling tumor...
Elizabeth A R Garfinkle,Elaine R Mardis
Elizabeth A R Garfinkle
The application of next-generation sequencing-based genomics and corresponding analytical pipelines have significantly improved our ability to identify tumor-unique antigenic peptides ("neoantigens") for the design of personalized vaccine t...
Ameya R Kirtane,Giovanni Traverso
Ameya R Kirtane
mRNA vaccines consist of antigen-encoding mRNA, which produces the antigenic protein upon translation. Coupling antigen production with innate immune activation can generate a potent, antigen-specific T-cell response. Clinical reports have ...
Cancer Vaccines [0.03%]
癌症疫苗
Elaine R Mardis
Elaine R Mardis