Jessica Oliver,Victor Gray,Linda S Li et al.
Jessica Oliver et al.
Over the past decades, the immunomodulatory properties of radiotherapy have started to be uncovered. This has prompted a new way of interpreting radiotherapy responses and opened novel avenues for combining radiotherapy with immunotherapy. ...
Matías Fernández Muñoz,Mai K Bishr,Ben O&#x;Leary et al.
Matías Fernández Muñoz et al.
Radiotherapy has been a key component of cancer treatment for over a hundred years, with the understanding that its action was driven only by direct and indirect toxic effects on the tumor cells. With the advent of immunotherapy in recent d...
Targeting Cancer-associated Fibroblasts (CAFs) to Optimize Radiation Responses [0.03%]
靶向癌症相关成纤维细胞以优化放射反应
Katie O&#x;Fee,Amy Burley,Sarah Stewart et al.
Katie O&#x;Fee et al.
Cancer-associated fibroblasts (CAFs) are an important component of the tumor microenvironment with diverse functions. CAFs are heterogeneous; although their roles are primarily tumor-promoting, recent research suggests that in specific cont...
Tumor Evolution Driving Genome Instability, Immune Interactions, and Response to Radiotherapy [0.03%]
驱动基因组不稳定性、免疫相互作用和放射治疗反应的肿瘤进化
George Seed,France Truong,Rahma Riahi et al.
George Seed et al.
This review article explores the role of immuno-radiotherapy in the context of genome instability and tumor evolution. Genomic changes in tumors exist in a delicate balance with the immune system, offering evolutionary pathways to adapt and...
Harnessing Immunogenic Cell Death to Boost the Impact of Radiation Therapy [0.03%]
利用免疫源性细胞死亡增强放射治疗的效果
Jonathan Mannion,Pascal Meier
Jonathan Mannion
Harnessing radiotherapy (RT) to effectively eliminate cancer cells has been a cornerstone of clinical oncology for decades. Beyond its well-established cytotoxic effects, RT triggers a diverse array of tumor cell death modalities, including...
Radiation-dependent Nucleic Acid Sensing, and Its Possible Impact on Radiotherapy [0.03%]
辐射依赖的核酸传感及其可能对放射治疗的影响
Robert J Pickering,Christian Zierhut
Robert J Pickering
DNA damage and chromosomal instability can promote sterile inflammatory responses in cells, similar to those induced by pathogen infection. Primary contributors to this phenomenon are cGAS-dependent and AIM2-dependent DNA-sensing mechanisms...
Charleen Chan Wah Hak,Magnus Dillon
Charleen Chan Wah Hak
The complex interplay between DNA damage (DDR) and immune responses presents therapeutic opportunities for enhancing antitumour immunity, particularly in the context of radiotherapy. We discuss how DNA damage leads to immunomodulation and h...
Kevin J Harrington,Saptha Veerapathiran,Alison C Tree
Kevin J Harrington
Are we Only Doing Good? Long-term Psychosocial Effects of Fertility Preservation (or Lack Thereof) on Survivors of Cancer During Adolescence and Young Adulthood [0.03%]
我们只是在做好事吗？生育力保存（或缺失）对青少年及青壮年期癌症幸存者长期的心理社会影响几何？
Vicky Lehmann,Niels van Poecke,Leah Waterman et al.
Vicky Lehmann et al.
Purpose/background: Patients diagnosed with cancer at reproductive age can be offered fertility preservation, which includes options of freezing sperm (male patients), oocytes, embryos, or ovarian tissue (female patients)...
The Current Landscape for Human Papillomavirus Vaccination in Oropharyngeal Carcinoma [0.03%]
人乳头瘤病毒疫苗在口咽癌中的应用现状
Nivedha Kumar,James S Butler,Jay Vashisht
Nivedha Kumar
Human papillomavirus is associated with the development of malignancies in the head and neck region, particularly oropharyngeal carcinoma. In recent years, there has been a significant increase in these virally mediated cancers, largely due...