Cardiovascular Risk Score (SCORE2) Predicts the Incidence and Severity of Cardiac Damage after Polytrauma - How to Identify At-risk Patients? [0.03%]
心血管风险评分（SCORE2）可预测多发伤后心脏损伤的发生和严重程度-如何识别高危患者？
Birte Weber,Larissa Sztulman,Victoria Pfeiffer et al.
Birte Weber et al.
Background: Cardiac damage predicts poor outcomes in polytrauma (PT). In older patients, cardiovascular risk factors may predispose to post-traumatic cardiac dysfunction. This study examined whether cardiovascular risk co...
Reply to the Letter to the Editor: Early Physiologic Deterioration versus True Risk Prediction: Methodological Considerations for SALI Nomogram Development [0.03%]
关于《编辑来信》的答复：生理早期恶化与真正风险预测：SALI列线图开发的方法学考量
Lulu Weng,Haidong Li,Jiawen Shi et al.
Lulu Weng et al.
CD74-Pax5 Regulates B-cell Function via PI3K/AKT Signaling Pathway in Sepsis [0.03%]
CD74-Pax5通过PI3K/AKT信号通路调节脓毒症中的B细胞功能
Zhongxue Feng,Xiaoyu Xiang,Chengyong Ma et al.
Zhongxue Feng et al.
Sepsis-induced B-cell dysfunction is a pivotal driver of adaptive immunosuppression, although the underlying molecular mechanisms remain incompletely elucidated. CD74, a multifunctional immunoregulatory protein, is known to mediate tumor im...
Pulmonary Artery Catheter Monitoring in Cardiogenic Shock: A Systematic Review and Meta-Analysis [0.03%]
心脏源性休克患者肺动脉导管监测的系统评价和 meta 分析
Jorge A Ortega-Hernández,Francisco Jose Chacon-Lozsan,Luca Baldetti et al.
Jorge A Ortega-Hernández et al.
Introduction: The role of pulmonary artery catheterization (PAC) in cardiogenic shock (CS) remains debated: prior intensive care unit trials showed no benefit, but contemporary observational registries suggest improved ou...
At the Edge of Chaos: Complexity Science and Critical Care in the Era of Artificial Intelligence [0.03%]
混沌边缘：人工智能时代的复杂科学与重症监护
L Nelson Sanchez-Pinto
L Nelson Sanchez-Pinto
Critical care unfolds at the crossroads of highly complex, nonlinear systems. The intersection of pathophysiology, human behavior, and clinical operations exemplifies this complexity. We can frame critical illnesses along two dimensions of ...
Dual Targeting of NET Formation and Coagulation Improves Survival and Organ Protection in Experimental Sepsis [0.03%]
双重靶向NET形成和凝血可改善实验性脓毒症的生存率和器官保护作用
Xiangqun Zhang,Junyuan Wu,Shubin Guo
Xiangqun Zhang
Background: Sepsis is a life-threatening critical illness characterized by dysregulated host responses, in which excessive neutrophil extracellular trap (NET) formation and sepsis-associated coagulopathy play central role...
Dynamic Profiling of Angiogenic, Metabolic, and Immune Checkpoint Biomarkers Predicts Chronic Critical Illness and Long-term Outcomes in Abdominal Sepsis [0.03%]
腹腔脓毒症的血管生成、代谢和免疫检查点生物标志物的动态分析可预测慢性重症和长期预后
Tianwei Xu,Chao Lin,Haoyang Huang et al.
Tianwei Xu et al.
Background: Many patients who survive abdominal sepsis develop Chronic Critical Illness (CCI), characterized by prolonged intensive care unit (ICU) stay, ongoing organ dysfunction, and poor one-year outcomes. Current seve...
STEAP4 Modulates Intestinal Barrier Dysfunction and Inflammatory Signaling Pathways in Ulcerative Colitis [0.03%]
STEAP4在溃疡性结肠炎中的作用及机制研究
Shimeng Xu,Peixian Chen,Xiang Shi et al.
Shimeng Xu et al.
Ulcerative colitis (UC) is characterized by intestinal barrier dysfunction and chronic inflammation, yet its underlying mechanisms remain incompletely understood. This study investigates the role of Six-transmembrane epithelial antigen of t...
Regulation of Inflammatory Responses and Apoptosis: sgp130fc as a Potential Therapeutic Agent for Sepsis-Associated Kidney Injury [0.03%]
炎症反应和细胞凋亡的调节：sgp130fc在防治脓毒症相关性急性肾损伤中的应用及其机制研究
Xuefang Liu,Ya Liu,Yuhong Chen et al.
Xuefang Liu et al.
Objective: This study aims to evaluate the therapeutic potential and underlying mechanisms of sgp130Fc, a selective inhibitor interleukin-6 (IL-6) trans-signaling, in mitigating sepsis-associated kidney injury (SAKI). ...
5'tiRNA-32-LysCTT-11 Alleviates Sepsis-Induced Myocardial Injury by stabilizing Mfn2 and inhibiting mitochondrial dysfunction-mediated necroptosis [0.03%]
5' tiRNA-32-LysCTT-11通过稳定Mfn2和抑制线粒体功能障碍介导的坏死性凋亡来缓解脓毒症诱导的心肌损伤
Jing Li,Ludong Yuan,Xiaofang Lin et al.
Jing Li et al.
Background: Transfer RNA-derived small RNAs (tsRNAs) represent a novel class of non-coding RNAs increasingly implicated in cardiovascular regulation. However, their roles in sepsis-induced cardiomyopathy (SICM) remain lar...