Association Between the Sequential Organ Failure Assessment-2 (SOFA-2) Score and 90-Day and 365-Day Mortality in Patients With Sepsis: A Retrospective Cohort Study Based on the MIMIC-IV Database [0.03%]
基于MIMIC-IV数据库的回顾性队列研究：脓毒症患者的序贯器官功能衰竭评估（SOFA-2）评分与90天和365天死亡率之间的关系
Zhengchao Li,Yuzhu Wang,Yudong Gao et al.
Zhengchao Li et al.
Background: The Sequential Organ Failure Assessment-2 (SOFA-2) score is a recently developed update of the conventional SOFA score that incorporates contemporary patterns of organ support in the intensive care unit (ICU)....
Identifying GADD45A as a potential R-loop regulator in sepsis via machine-learning and multi-omics analysis [0.03%]
通过机器学习和多组学分析识别GADD45A作为潜在的脓毒症R环调节因子
Min Chen,Jie-Xiang Kang,Shi-Ling He et al.
Min Chen et al.
Background: Sepsis is a life-threatening syndrome characterized by dysregulated immune responses, while the molecular basis of immune dysfunction remains unclear. Increasing evidence suggests that R-loop accumulation and ...
Sex-Based Differences in Severe Trauma and Hemorrhagic Shock: A Systematic Review of Pre-Clinical and Veterinary Animal Studies [0.03%]
基于性别的重度创伤和失血性休克差异的系统评价：从前期临床研究和兽医动物实验中获得的证据
Gennadi Saiko,Fazle Kibria,Denis Bragin
Gennadi Saiko
Purpose: To systematically review preclinical studies to determine whether biological sex alters outcomes after severe trauma with hemorrhagic shock (T/HS), identify the mechanistic drivers of any sex dimorphism, and defi...
Phenotyping Sepsis at Emergency Department Presentation Using Early Clinical Data: A Multicenter Cohort Study [0.03%]
基于早期临床数据的急诊重症脓毒症表型研究：一项多中心队列研究
Junhyuk Seo,Namkee Oh,Gee Young Suh et al.
Junhyuk Seo et al.
Background: Sepsis is heterogeneous, and early emergency department (ED) management is constrained by limited information and dynamic clinical trajectories. ...
Julia Kleinhapl,Lucineia Gainski Danielski,Kristine Knappskog et al.
Julia Kleinhapl et al.
Background: Burn injury is frequently complicated by shock, critical illness, and multi-organ dysfunction, all of which may contribute to renal injury. While acute renal complications are well recognized, long-term renal ...
Low pan-immune-inflammation value is associated with increased mortality in septic patients with immunocompromised status: a multicenter retrospective cohort study [0.03%]
低免疫炎症值与免疫抑制状态的脓毒症患者预后不良有关：多中心回顾性队列研究
Qingyu Zhao,Xuyang Ji,Shuxing Wei et al.
Qingyu Zhao et al.
Background: Pan-immune-inflammation value (PIV) is a readily available biomarker reflecting systemic inflammatory and immune status. Although elevated PIV is generally associated with adverse outcomes, its prognostic sign...
Disruption of mitochondria-associated ER membranes: a novel mechanism for high-salt diet-exacerbated hemorrhagic shock-induced lymphatic dysfunction [0.03%]
高盐饮食加重失血性休克诱导的淋巴损伤通过扰乱内质网-线粒体接触点机制
Hong-Li Han,Yang Liu,Yu-Yao Hao et al.
Hong-Li Han et al.
Background: Although high-salt diet (HSD) impairs cardiovascular function, its impact on the prognosis of hemorrhagic shock (HS) has not been elucidated. Impaired mesenteric lymphatic contractility post-HS contributes to ...
MiR-340-5p acts as a lung protective factor in sepsis-induced acute lung injury by inhibiting ROCK1 [0.03%]
miR-340-5p通过抑制ROCK1在脓毒症诱导的急性肺损伤中发挥肺保护作用
Yuan Zhang,Fangning Liu
Yuan Zhang
Objective: This study aims to explore the role of miR-340-5p in sepsis-related acute lung injury (ALI). Methods: Firstly, ROC curve and...
Metabolic Syndrome and In-Hospital Mortality in Sepsis: A Multicenter Cohort Study Revealing a Severity-Dependent Survival Advantage Driven by Overweight and Hyperlipidemia [0.03%]
代谢综合征与脓毒症住院死亡率相关：一项多中心队列研究揭示由超重和高脂血症驱动的生存优势具有不同严重程度依赖性
Yining Zhang,Guoxiang Liu,Xianxian Yu et al.
Yining Zhang et al.
Objectives: To evaluate the association between metabolic syndrome (MetS) and in-hospital mortality in sepsis patients and to determine whether this association varies according to disease severity and individual MetS-rel...