Blood Glucose Trajectories and Mortality in Sepsis-Induced Coagulopathy: A Latent Growth Mixture Modeling Analysis [0.03%]
latent growth mixture modeling分析败血症凝血病血糖轨迹与死亡率的关系
Kai Qi,Chenjia Guo,Linhua Yang
Kai Qi
Background: Sepsis-induced coagulopathy (SIC) is a severe complication contributing significantly to mortality in critically ill patients. While hyperglycemia is a known risk factor, the prognostic value of longitudinal b...
Transcriptome and experimental verification identified candidate biomarkers related to mitochondrial metabolism in sepsis-associated encephalopathy [0.03%]
转录组和实验验证鉴定出与脓毒症性脑病相关线粒体代谢候选生物标志物
Ran Zhou,Hao Fang,Herui Li et al.
Ran Zhou et al.
Background: Mitochondrial metabolism (MM) abnormalities have been implicated in multiple diseases, but its contribution to sepsis-associated encephalopathy (SAE) remains insufficiently understood. The purpose of this rese...
Unveiling the Metabolic Profiles and Identifying Early Diagnostic Biomarkers for Sepsis-Associated Acute Kidney Injury Based on Untargeted Metabolomics [0.03%]
基于非靶向代谢组学揭示脓毒症相关急性肾损伤代谢谱型及发现早期诊断生物标志物
Dandan Li,Yi Gou,Nazila Haireti et al.
Dandan Li et al.
Background: Sepsis-associated acute kidney injury (SA-AKI) is a critical condition associated with high morbidity and mortality rates. Elucidating metabolic alterations and identifying early diagnostic biomarkers is essen...
Translocator protein deficiency promotes splenomegaly with extramedullary hematopoiesis after sepsis [0.03%]
败血症后促进髓外造血的脾大伴随移位蛋白缺乏症
Kazuya Kikutani,Xiao Lyu,Miyuki Hattori et al.
Kazuya Kikutani et al.
The translocator protein 18 kDa (TSPO) is expressed in immune cells such as macrophages and hematopoietic progenitors and is involved in modulating innate immune responses. However, a role of TSPO in post-sepsis immune dysregulation remains...
Extracellular Vesicles Derived From Mesenchymal Stem Cells Ameliorate Bronchopulmonary Dysplasia in Mle-12 Cells and Neonatal Mice by Downregulating Mir-34A [0.03%]
外源性间充质干细胞衍生的细胞通过下调Mir-34A来缓解Mle-12细胞和新生小鼠的支气管肺发育不良
Qing Mu,Rong Zhu,Yuanyuan Shi et al.
Qing Mu et al.
Background: Bronchopulmonary dysplasia (BPD) represents a multifaceted, chronic lung disorder caused by extensive oxygen exposure. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been increasingly repo...
Qualitative and Quantitative Analysis of Circulating Net-Derived Chromatin and Nucleosomes in Severe Thermal and Traumatically Injured Patients [0.03%]
严重烧伤和创伤患者循环NETs及核小体的定性和定量分析
Ali Asiri,Jon Hazeldine,Naiem Moiemen et al.
Ali Asiri et al.
Objectives: This study evaluates the dynamic changes in the quantity and quality of neutrophil-derived cell-free DNA (cfDNA) in whole blood and plasma samples from severe thermal and traumatically injured patients. ...
A Novel Therapeutic Strategy for Sepsis: The Multiorgan Protective Properties and Clinical Potential of Ulineastatin [0.03%]
乌拉地尔在治疗重症肺炎中的临床研究及多器官保护作用和临床潜力的新治疗策略的研究
Hong Zhang,Xuan Liang,Xing-Hua Liu et al.
Hong Zhang et al.
Sepsis, a life-threatening systemic inflammatory response induced by infection, remains a major therapeutic challenge with high mortality rates, especially when progressing to multiple organ dysfunction syndrome. Ulinastatin (UTI), a serine...
Heat Shock Protein 90 In Sepsis-Induced Cardiomyopathy: Mechanistic Insights And Emerging Therapeutic Target [0.03%]
热休克蛋白90在脓毒症诱导的心肌病中的作用机制及新兴治疗靶点
Xiong Yue,Meimei Hu,Cunmin Zhou et al.
Xiong Yue et al.
Sepsis-induced cardiomyopathy (SIC) is a form of cardiac dysfunction triggered by sepsis, whose pathogenesis primarily involves the release of endogenous danger signal molecules. As a key molecular chaperone, Heat Shock Protein 90 (Hsp90) p...
A BAR-based nomogram for predicting septic shock in patients with acute pancreatitis complicated by sepsis: development and external validation [0.03%]
基于急性胰周坏死感染患者发生脓毒症休克列线图的建立及外部验证
Jiajing Xing,Xiaoli Xie,Weiwei Niu et al.
Jiajing Xing et al.
Background: Septic shock is a common and life-threatening complication in patients with acute pancreatitis complicated by sepsis, yet rapid and accurate tools for early risk prediction remain limited in clinical practice....
Effects and mechanisms of NAD + on lung injury after cardiac arrest and cardiopulmonary resuscitation in swine [0.03%]
NAD+对心脏骤停和心肺复苏后猪肺损伤的影响及机制研究
Meisong Chen,Yufeng Hu,Xuelin Yang et al.
Meisong Chen et al.
Introduction: This study aimed to investigate the effects of nicotinamide adenine dinucleotide (NAD⁺) on lung injury after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in swine and to explore the potential...