Optimization of Preclinical Rodent Research Models of Human Shock: Part 2 Trauma, Burn, and the Gut Microbiome [0.03%]
优化人类休克的临床前啮齿动物研究模型（第二部分）：创伤、烧伤和肠道微生物群
Christine Rodhouse,Whitman Bertram Wiggins,Zoe Michael et al.
Christine Rodhouse et al.
Rodent models are critical tools in the study of trauma and burn injury, giving mechanistic insights into the unique pathophysiological response and the systemic complications that follow. These models allow researchers to control injury pa...
Synopsis July [0.03%]
七月小辑
Stefanie Flohe
Stefanie Flohe
Reply - Letter to the Editor: Clinical and Immunologic Effects of Extracorporeal Cytokine Removal in Patients with Septic Shock: A Randomized Controlled Trial [0.03%]
致编辑信件的回复——脓毒性休克患者体外细胞因子清除的临床及免疫学效应：一项随机对照试验
Christopher Lotz,Quirin Notz
Christopher Lotz
Comparative performance of reverse shock index multiplied by simplified motor score (rSI-sMS) and conventional indices for predicting outcomes in trauma patients: a retrospective analysis of a 13-year multicenter prospectively maintained trauma registry [0.03%]
逆转序冲击指数与简化motor评分（rSI-sMS）预测创伤患者预后的效能及与传统评分的比较：一项基于多中心前瞻性创伤登记数据库的回顾性分析研究
Yi-Ta Ho,Ya-Chih Yang,Huai-Kuan Huang et al.
Yi-Ta Ho et al.
Background: The reverse shock index multiplied by the simplified motor score (rSI-sMS) can rapidly reflect hemorrhagic shock and neurological status for rapid injury severity assessment in trauma patients during the emerg...
Early STAT3 Activation and Delayed STAT5 Dominance Define the Acute Leukocyte Signaling Response to Trauma and May Correlate with Clinical Outcomes [0.03%]
STAT3早期活化及STAT5晚期占优势定义了创伤后白细胞的急性信号传导反应可能与临床结果相关
Matthew Montoya Rush,Mark H Hoofnagle,Grace M Niziolek et al.
Matthew Montoya Rush et al.
Major trauma dysregulates the immune system, leaving injured patients at increased risk of infection. Despite extensive research to define the effect of trauma of the immune system, there are no effective interventions to restore immune fun...
Elucidating the Pathophysiology and Diagnostic Biomarkers of Sepsis-Associated Encephalopathy: A Multiomics Approach [0.03%]
多组学方法阐明脓毒症相关性脑病的病理生理及诊断生物标志物
Yuechen Zhang,Yun Xie,Zhouxing Zhang et al.
Yuechen Zhang et al.
Sepsis-associated encephalopathy (SAE) is a diffuse neurological injury that results from severe sepsis, and its underlying pathophysiological mechanisms remain largely unknown. This study aimed to elucidate the pathological basis of SAE an...
Renal veno-arterial pCO2 gap fails to detect renal medulla microcirculatory changes in a large animal model of sepsis-associated acute kidney injury [0.03%]
大动物模型中肾静脉-动脉pCO2差值不能检测脓毒症相关急性肾损伤的肾髓质微循环变化
Jiri Müller,Lenka Valesova,Jiri Chvojka et al.
Jiri Müller et al.
The difference in carbon dioxide partial pressure between arterial and mixed venous blood has been recognized as a marker of the adequacy of cardiac output. However, the extent to which global pCO2 gap accurately reflects regional organ blo...
Impact of Oxygen Targets on Sepsis Outcome: A Randomized Controlled Trial [0.03%]
氧疗目标影响重症脓毒症患者预后的随机对照临床研究：一项多中心随机试验
Xi Chen,Wei Wen,Liangliang Zheng
Xi Chen
Background: Sepsis is a clinical syndrome marked by a dysregulated host response to infection, impairing oxygen delivery and utilization and causing organ dysfunction. Hypoxemia, which can cause significant tissue and org...
Plasma regulates homeostatic pulmonary endothelial signaling to mitigate vascular leak following polytrauma and hemorrhagic shock [0.03%]
血浆通过调节多发伤和出血性休克后维持肺内皮细胞信号转导来减轻血管渗漏
Taylor E Wallen,Krystal L Rivera-Figueroa,James D Odum et al.
Taylor E Wallen et al.
Introduction: In hemorrhagic shock, plasma resuscitation preserves vascular integrity and protects against trauma-induced coagulopathy and organ injury. Despite demonstrated clinical benefit, the endothelial mechanisms un...
Resveratrol attenuates sepsis-induced lung injury by suppressing NLRP3-mediated pyroptosis [0.03%]
白藜芦醇通过抑制NLRP3介导的炎性焦亡减轻内毒素致急性肺损伤中小鼠的全身炎症反应
Yu-Ting Li,Xiao-Qi Yue,Jun-Chao Liu et al.
Yu-Ting Li et al.
Background: Sepsis-induced acute lung injury (ALI) is a severe condition with a high mortality rate and limited treatment options. Although NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasom...