Serum IL-6 levels in sepsis predict the development of sepsis-induced disseminated intravascular coagulation [0.03%]
血清IL-6水平可以预测脓毒症患者的继发性DIC的发展趋势
Kosuke Kato,Masayuki Ozaki,Masanobu Tsuda et al.
Kosuke Kato et al.
Disseminated intravascular coagulation (DIC) significantly increases sepsis mortality rates to 40-80%, making early identification crucial for improved outcomes. Interleukin-6 (IL-6) promotes leukocyte activation and immunothrombosis while ...
AI-Driven Real-Time Hyperlactatemia Prediction in ICU: A Multi-Cohort International Retrospective Study with External Validation [0.03%]
基于人工智能的ICU实时乳酸血症预测：一项多队列国际回顾性研究及外部验证
Simone Zappalà,Lucrezia Rovati,Francesca Alfieri et al.
Simone Zappalà et al.
Background: Blood lactate is a key biomarker of tissue hypoperfusion and metabolic distress, reflecting the balance between oxygen delivery and cellular metabolism. Early identification of rising lactate levels is critica...
A Single-Center Study: XGBoost-Based Multi-Omics Prediction Model for Sepsis-Associated Acute Kidney Injury (SA-AKI) and Personalized Immune Therapy Efficacy in Pancreatic Cancer ICU Patients [0.03%]
单中心研究：基于XGBoost的多组学预测模型在脓毒症相关急性肾损伤（SA-AKI）及胰腺癌ICU患者的个性化免疫治疗疗效中的应用
Zhanzhi Long,Ying Fu,Shuren Wang et al.
Zhanzhi Long et al.
Background: Sepsis-associated acute kidney injury (SA-AKI) is a highly prevalent and lethal complication in pancreatic cancer patients admitted to the intensive care unit (ICU), characterized by complex pathophysiology in...
Mesenchymal Stem Cell-Derived Extracellular Vesicles Mitigate Immune Cell Activation in an In Vitro Model of Post-Resuscitation Inflammation [0.03%]
间充质干细胞来源的外泌体减轻复苏后炎症的体外模型中的免疫细胞活化
Tyler J Rolland,Sumbule Zahra,Luke A Graser et al.
Tyler J Rolland et al.
Background: Systemic inflammation is a well-established component of post-cardiac arrest syndrome (PCAS), a condition responsible for significant morbidity and mortality in patients who are initially resuscitated from sud...
M1 Macrophage-Derived Exosomes Promote Intestinal Barrier Dysfunction and Pyroptosis in Sepsis by Modulating NLRP3 Inflammasome Activation [0.03%]
M1型巨噬细胞源外泌体通过调节NLRP3炎症小体活化促进脓毒症肠道屏障功能障碍及Pyroptosis发生
Tao Yang,Zhifen Wang,Haiyan Wu et al.
Tao Yang et al.
Background: Intestinal barrier injury is pivotal in sepsis deterioration. M1 macrophage-derived exosomes (M1-Exos) promote gut inflammation. We aimed to reveal the roles of M1-Exos in sepsis-induced gut barrier injury and...
"Interpreting Hemoadsorption in Septic Shock: methodological considerations and dosing implications" [0.03%]
「严重感染性休克患者血浆吸附治疗的疗效评估：方法学问题及剂量探讨」
Gabriella Bottari,Federico Pappalardo,Filippo Aucella et al.
Gabriella Bottari et al.
The Efficacy of Whole Blood Exchange- Lymphoplasmapheresis Combined Transfusion in Sepsis with Anemia [0.03%]
全血置换联合血浆置换输注治疗脓毒症合并贫血的疗效分析
Run Yao,Danyang Yan,Xiangjie Fu et al.
Run Yao et al.
Background: Sepsis progression is driven by a dysregulated immune response and persistent leukocyte activation. Inflammation-induced hemolysis also places septic patients at high risk for anemia. Whole blood exchange has ...
Evaluation of tissue perfusion in septic shock using cardiac output monitoring and transcutaneous oxygen challenge test: A prospective observational study [0.03%]
应用心排血量监测及经皮氧挑战试验评估感染性休克组织灌注：一项前瞻性观察研究
Xiu Peng,Xiaoling Li,Jijia Bai et al.
Xiu Peng et al.
Objective: To evaluate tissue perfusion in patients with septic shock using oxygenation and cardiac output (CO) monitoring. Methods: Th...
Subphenotypes of Infection in the Emergency Department: Clustering Analysis from Routine Parameters to Predict Early Deterioration [0.03%]
基于常规参数的急诊感染亚型分组分析及早期恶化预测能力研究
Manon Dumolard,Anaëlle Nardot-Suchaud,Henri Hani Karam et al.
Manon Dumolard et al.
Anticipating sepsis and infection-related deterioration in the ED remains challenging due to the limited accuracy of available individual scores and biomarkers. We performed an unsupervised hierarchical cluster analysis using routine variab...
Bridging bench to bedside: mechanistic elucidation and clinical translation of vasopressin and its analogues for hemorrhagic shock resuscitation [0.03%]
从实验室到临床：血管加压素及其类似物在出血性休克复苏中的机制阐明与转化研究
Shouyin Jiang,Bojin Chen,Lei Wang et al.
Shouyin Jiang et al.
Hemorrhagic shock remains a leading cause of preventable mortality in civilian and military trauma, despite advances in trauma systems and resuscitation strategies. Vasopressor therapy for early resuscitation is controversial, as convention...