Mariana R Brewer,Clifford S Deutschman,Matthew D Taylor
Mariana R Brewer
Murine sepsis models are limited by an inability to recapitulate several common features of human sepsis. One possible explanation is that laboratory mice lack the robust preexisting memory T cell repertoire that is a key feature of the hum...
Integrative Analysis Identifies Lactylation-Associated Hub Genes in Septic Cardiomyopathy [0.03%]
整合分析鉴定出脓毒症心肌病中的乳酰化核心基因
Rui Jin,Jinwei Dai,Xiaolei Zhang et al.
Rui Jin et al.
Objective: Septic Cardiomyopathy (SCM) is a critical complication contributing to high mortality in septic patients, yet its precise molecular mechanisms remain incompletely elucidated. ...
Circulating Nucleosomes Are Elevated In Trauma Patients With Venous Thromboembolism: A Prospective Case-Cohort Study [0.03%]
创伤患者静脉血栓栓塞症患者循环核小体水平升高：前瞻性队列研究
Sergio M Navarro,Riley J Thompson,Grant M Spears et al.
Sergio M Navarro et al.
Methods: Trauma patients (pts) presenting to a Level I trauma center were evaluated for inclusion in a prospective case-cohort study, and citrated blood samples were collected within 12 hours of injury. Pts were followed ...
Serpine1 mediates cardiac fibrosis following myocardial ischemia-reperfusion injury by activating the endothelial-mesenchymal transition process and inducing mitochondrial damage [0.03%]
缺血再灌注损伤后Serpine1通过激活内皮间充质转化过程和诱导线粒体损伤介导心脏纤维化
Fen Zhang,Jie Wu,Xingxing Li et al.
Fen Zhang et al.
Background: Cardiac fibrosis represents a severe pathological consequence following myocardial ischemia-reperfusion (MI/R) injury. This study aims to investigate the underlying molecular mechanisms of Serpine1 in post-MI/...
Smad7 Downregulation Promotes Ferroptosis in Pulmonary Arterial Hypertension via the TGF-β1-Smad2/3 Pathway [0.03%]
Smad7下调通过TGF-β1-Smad2/3信号通路促进肺动脉高压的铁死亡
Wenhui Huang,Xueying Wang,Wenteng Wu et al.
Wenhui Huang et al.
Background: In pulmonary arterial hypertension (PAH), ferroptosis could influence vascular remodeling by affecting the pulmonary artery endothelial cells (PAECs). However, the underlying pathogenic mechanisms of ferroptos...
Diffuse Correlation Spectroscopy for Non-invasive Monitoring of Peripheral Perfusion During Cardiogenic Shock and VA-ECMO Support: An Experimental Study [0.03%]
用于心脏骤停性休克和VA-ECMO支持外周灌注非侵入监测的漫射相关光谱技术：一项实验研究
Hiroki Matsushita,Kenta Oba,Koki Kurono et al.
Hiroki Matsushita et al.
Introduction: In cardiogenic shock (CS), persistent microcirculatory impairment despite improved macrocirculatory parameters is associated with poor outcomes. Therapeutic strategies must therefore address both macro- and ...
Global Research Landscape and Emerging Frontiers of Heparin-Binding Protein in Sepsis and Infection: A Bibliometric Mapping Study [0.03%]
败血症与感染背景下肝素结合蛋白的研究态势和前沿分布：文献计量共引分析映射研究
Khalid Waleed,Ai Peng,Zuorui Zheng et al.
Khalid Waleed et al.
Heparin-binding protein (HBP), also known as azurocidin, is a neutrophil-derived mediator that modulates vascular permeability and inflammatory responses and has been actively studied in relation to infection and sepsis. Despite significant...
Effects of Different Ventilation Rates on Resuscitation in a Porcine Ventricular Fibrillation Cardiac Arrest Model [0.03%]
不同通气量对猪室颤心脏骤停复苏的影响研究
Hongmeng Dong,Yudan Cao,Jingyi Wang et al.
Hongmeng Dong et al.
Objective: We tested the a priori hypothesis that a ventilation rate of 20 breaths per minute (bpm) is non-inferior to 10 bpm and 5 bpm with respect to resuscitation outcomes and physiology following advanced airway place...
Neutrophil Transcriptomic Changes in Severe Sterile Vasoplegic Syndrome Resemble a Distinct Molecular Subtype of Septic Shock [0.03%]
严重无菌性血管渗漏综合征的中性粒细胞转录组变化类似于脓毒症的一类分子亚型
Anaar E Siletz,Kindra M Kelly-Scumpia,Phillip O Scumpia et al.
Anaar E Siletz et al.
Background: Understanding early molecular events in systemic inflammation in sepsis is complicated by host-pathogen interactions and responses over time. Vasoplegic syndrome after cardiac surgery resembles septic shock bu...