Long-chain polyunsaturated fatty acid lipid and oxylipin alterations in postoperative delirium after cardiac surgery [0.03%]
心脏手术后术后谵妄患者的长链多不饱和脂肪酸、脂质和氧脂素变化研究
Kwame Wiredu,Pruthvi Gowda,James Rhee et al.
Kwame Wiredu et al.
Lipids play a crucial role in signaling, membrane dynamics, and inflammatory regulation, yet their involvement in postoperative delirium pathogenesis remains unclear. This study examined serum lipidomic alterations in postoperative delirium...
Amino acid residues L261, W264, F265, L268, and V269 of Apolipoprotein E4 critically regulate adipose tissue metabolism [0.03%]
载脂蛋白E4的L261、W264、F265、L268和V269氨基酸残基可调节关键的脂肪组织代谢功能
Evangelia Zvintzou,Panagiota C Giannopoulou,Katerina Giannatou et al.
Evangelia Zvintzou et al.
Apolipoprotein E (APOE) plays a tissue-specific role in diet-induced obesity: brain-expressed APOE promotes obesity, while hepatic APOE appears protective. Physiological plasma APOE levels facilitate clearance of atherogenic lipoproteins; h...
17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP-induced local inflammation by inhibiting neutrophil infiltration [0.03%]
17,18-环氧二十碳四烯酸通过抑制中性粒细胞浸润缓解mRNA-LNP诱导的局部炎症反应
Keigo Iemitsu,Ken Yoshii,Yuki Hirayama et al.
Keigo Iemitsu et al.
Lipid nanoparticles (LNPs) are a powerful technology for delivering nucleic acids into cells and have greatly contributed to the development of SARS-CoV-2 mRNA vaccines and nucleic acid-based therapeutics. However, side effects such as pain...
Spatial and Temporal Brain Biodistribution of Neuropathogenic Sphingolipids of Krabbe Disease [0.03%]
克罗贝病神经毒性鞘脂的脑内分布时空动态学研究
Tingting Yan,Shih-Chang Hsueh,Salma Begum et al.
Tingting Yan et al.
Glycosphingolipids are essential lipids enriched in the outer leaflet of the plasma membrane, particularly those forming the myelin sheaths. Disorders impacting the glycosphingolipid metabolism cause devastating demyelinating diseases. The ...
Proteomic analysis of HDL isolates reveals method-driven variability: an interlaboratory approach [0.03%]
蛋白质组分析显示HDL分离物存在方法驱动的差异性：基于多家实验室的方法
Francielle Aguiar Gomes,Douglas Ricardo Souza Junior,Michael Holzer et al.
Francielle Aguiar Gomes et al.
The high-density lipoprotein (HDL) is the most heterogeneous and protein-rich lipoprotein, and its complex proteome has been correlated with many distinct properties. However, the lack of a standardized approach for HDL isolation, combined ...
Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson's Disease [0.03%]
帕金森病中鞘氨醇和糖鞘脂代谢的失调
Yu-Fong Peng,Szu-Ju Chen,Jeng-Lin Li et al.
Yu-Fong Peng et al.
Background: Alterations in sphingolipid metabolism have been implicated in the pathogenesis of Parkinson's disease (PD), yet findings regarding peripheral sphingolipid changes remain inconsistent. This study aimed to eluc...
S-palmitoylation of MTDH regulates ferroptosis resistance in breast cancer cell [0.03%]
乳腺癌细胞中MTDH的S-棕榈酰化调控铁死亡抵抗作用
Shaojun Pei,Wen Wang,Tingze Feng et al.
Shaojun Pei et al.
S-palmitoylation is a dynamic and reversible post-translational modification that plays crucial roles in cancer progression. Here, we found the oncogene of metadherin (MTDH) modulates lipid metabolism and ferroptosis by its S-palmitoylation...
Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation [0.03%]
与Tauon P301S突变相关的额颞叶变性的脑脂质组特征分析
Almudena Maroto Juanes,Thomas Vogels,Sascha Koppes-den Hertog et al.
Almudena Maroto Juanes et al.
Mutations in microtubule-associated protein Tau (MAPT), the gene that codes for the protein Tau, cause frontotemporal lobar degeneration (FTLD) with phenotypes ranging from behavioral changes to cognitive impairment and parkinsonism. Recent...
Serum cholic acid and cecal Faecalibaculum increase in a male-specific manner in a murine hepatocellular carcinoma model [0.03%]
在小鼠肝细胞癌模型中以雄性为主增加的血清胆酸和结肠Faecalibaculum菌群增多
Angela E Dean,Douglas V Guzior,Robert A Quinn et al.
Angela E Dean et al.
Hepatocellular carcinoma (HCC) has a higher incidence in males and is a leading cause of cancer-related deaths, which lacks effective therapies and surveillance markers. Using a murine model of bile acid excess (farnesoid X receptor and sma...
Deletion of MMP12 improves energy metabolism and brown adipose tissue function in mice prone to cardiometabolic disease [0.03%]
MMP12缺失可改善易患心血管代谢性疾病的鼠的能量代谢和棕色脂肪组织功能
Melina Amor,Malena Diaz,Alexander Fuerlinger et al.
Melina Amor et al.
Matrix metalloproteinase-12 (MMP12) is a proinflammatory macrophage-secreted protein with immunomodulatory functions that affects neutrophil infiltration, cytokine release, macrophage recruitment, and proliferation. We have previously demon...