Farnesyl transferase inhibitor KO-2806 (darlifarnib) enhances the anti-tumor activity of tyrosine kinase inhibitors in RCC [0.03%]
法尼基转移酶抑制剂KO-2806（达利法铵）可增强酪氨酸激酶抑制剂在肾细胞癌中的抗肿瘤活性
Jovylyn G Gasendo,Stacia Chan,Hetika V Patel et al.
Jovylyn G Gasendo et al.
Anti-angiogenic tyrosine kinase inhibitors (TKIs) targeting VEGFR remain the backbone of therapy in advanced renal cell carcinoma (RCC). However, durability of responses is limited, and resistance typically arises. Thus, there is an urgent ...
DHX9 inhibition enhances paclitaxel sensitivity by inducing mitotic failure in ovarian and endometrial cancers [0.03%]
DHX9抑制通过诱导卵巢癌和子宫内膜癌有丝分裂失败而增强紫杉醇敏感性
Tzu-Ting Huang,Jayakumar R Nair,Courtney Bowen et al.
Tzu-Ting Huang et al.
Recurrent high-grade serous ovarian carcinoma (HGSOC) and endometrial cancer (EC) remain major clinical challenges with limited effective treatment options. DHX9, a DNA/RNA helicase essential for genomic stability, has not yet been explored...
Delivery of ATSP-7041 by Minimally Invasive Nasal Depot (MIND) to Target Diffuse Intrinsic Pontine Glioma [0.03%]
通过微创鼻腔缓释(MIND)给药ATSP-7041治疗弥漫性内生型脑桥胶质瘤(DIPG)研究
Andy J Chua,Valentina Di Francesco,Bethany Tesar et al.
Andy J Chua et al.
Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor with limited therapeutic progress due to its infiltrative brainstem location, blood-brain barrier (BBB), and resistance to systemic agents. We present a novel strateg...
Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across sarcomas affecting the young [0.03%]
全面的多平台酪氨酸激酶谱分析揭示了影响年轻人的软组织肉瘤中的FGFR异常的新治疗靶点
Ashleigh M Fordham,Lauren M Brown,Chelsea Mayoh et al.
Ashleigh M Fordham et al.
Limited targeted agents are approved for pediatric sarcomas. Tyrosine kinase (TK) inhibitors have shown clinical efficacy in some, but not all, young sarcoma patients. A major obstacle preventing further advances and clinical implementation...
A bispecific anti-fluorescein x anti-CD3 T-cell engager in combination with fluoresceinated adaptors enables lysis of AML cells [0.03%]
双特异性抗荧光素×抗CD3 T细胞衔接器结合荧光素适配体，可使AML细胞裂解
Laura G Volta,Celeste Gobbi,Christian Koch et al.
Laura G Volta et al.
Tumor-targeting antibodies, antibody-drug conjugates, and radionuclide antibody conjugates are established therapeutic tools in clinical use. Beyond, bispecific T-cell engaging antibodies (TCEs) and chimeric antigen receptor (CAR) T-cells a...
Amanitin-Based Fc-Small Molecule Drug Conjugates with Non-Cleavable Linker: A Novel Therapeutic Strategy for Prostate Cancer Targeted Therapy [0.03%]
一种新型非裂解型小分子-抗体药物偶联物AMI-Fc-1的体内外抗肿瘤活性研究
Daniela Carraturo,Francesca Gallo,Marisa Schmitt et al.
Daniela Carraturo et al.
Prostate cancer remains a major global health burden, with limited options and poor prognosis in advanced stages. To extend survival and improve quality of life for patients, targeted therapies have become an emerging treatment modality. An...
Dynamic switching of apoptosis-modulating BIM heterodimers in response to BH3 mimetics in xenograft models of hematologic malignancies [0.03%]
异种移植模型中针对血液系统恶性肿瘤的BH3模拟物诱导的促凋亡调节蛋白BIM异二聚体动态转换响应机制研究
Jeevan Prasaad Govindharajulu,Sharon Fluss,Melinda G Hollingshead et al.
Jeevan Prasaad Govindharajulu et al.
This study tested the hypothesis that tumor cells can evade apoptosis following BH3 mimetic treatment by utilizing alternative Bim binding partners. Levels of Bim heterodimers with Mcl-1, Bcl-2 and Bcl-xL were measured in multiple hematolog...
Balancing the Dual Mechanisms of Anti-VISTA mAbs for Anti-Tumor Activity: CD8+ T Cell Responses and Fc-dependent Depletion of VISTA-Expressing Immune Cells [0.03%]
抗VISTA单克隆抗体的抗癌活性的双重机制：CD8⁺T细胞反应和VISTA表达免疫细胞的Fc依赖性耗尽作用间的平衡关系
Miaomiao He,Tianqi Cao,Kailun Wang et al.
Miaomiao He et al.
V-domain immunoglobulin suppressor of T cell activation (VISTA) is a negative immune checkpoint and an emerging target for cancer immunotherapy, yet its broad expression on myeloid cells and T cells has complicated therapeutic antibody deve...
TNIK overexpression is sufficient for chemoradiation resistance in limited-stage small cell lung cancer [0.03%]
TNK基因过度表达足以使小细胞肺癌产生放化疗耐药性
Dipanwita Dutta Chowdhury,Eddie L Imada,Nick Connis et al.
Dipanwita Dutta Chowdhury et al.
Small cell lung cancer (SCLC) is characterized by early metastasis, intrinsic chemoradiation resistance and tumor recurrence. Besides the lack of potentially targetable oncogenic drivers, therapeutic advancements are also hindered by the sc...
MRTX1133 suppresses ERK signaling but elicits context-dependent antiproliferative responses in KRAS (G12C) cancer cells [0.03%]
MRTX1133 抑制 ERK 信号通路，但在 KRAS(G12C) 癌细胞中产生上下文相关的抗增殖反应
Abraham C Sianoya,Yan Zuo,Cynthia V Pagba et al.
Abraham C Sianoya et al.
KRAS is a high-value therapeutic target for the treatment of cancer. Two covalent inhibitors, sotorasib and adagrasib, which target a specific codon 12 mutation (G12C), had received accelerated approvals for clinical use. Studies of these i...