Balancing the Dual Mechanisms of Anti-VISTA mAbs for Anti-Tumor Activity: CD8+ T Cell Responses and Fc-dependent Depletion of VISTA-Expressing Immune Cells
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V-domain immunoglobulin suppressor of T cell activation (VISTA) is a negative immune checkpoint and an emerging target for cancer immunotherapy, yet its broad expression on myeloid cells and T cells has complicated therapeutic antibody development. Here, we re... ...
