Ribosomal readthrough as an alternative therapy for hemophilia patients with nonsense mutations [0.03%]
无意义突变血友病患者的核糖体读码框偏移的替代疗法
Zhigang Liu,Vishal Srivastava,Aabid Hussain et al.
Zhigang Liu et al.
Background: Drug-induced readthrough can rescue nonsense mutations by inserting a replacement amino acid at the premature termination codon. Hemophilia A (HA) is well-suited for this therapy as even modest increases in co...
Thrombolytic drugs for ischemic stroke: Historical perspective, State of play and future developments [0.03%]
溶栓药物治疗缺血性卒中的历史、现状及未来展望
Bamlaku Enawgaw Walie,Christoph E Hagemeyer,Rong Xu et al.
Bamlaku Enawgaw Walie et al.
Thrombolytic agents are serine proteases or related enzymes that facilitate blood clot breakdown via a process called thrombolysis. They work either indirectly, via activation of plasminogen into plasmin, a potent fibrin-degrading enzyme, o...
TET2 Mutations in Myeloproliferative Neoplasms: Potential Mediation of Atrial Fibrillation by IL-1β and Impact on Stroke Risk in Clinical Cohorts [0.03%]
TET2基因突变与骨髓增生性肿瘤患者房颤风险增加及血栓事件高危之间的关联研究
Guangshuai Teng,Minghui Duan,Ke Shang et al.
Guangshuai Teng et al.
Objective: To investigate the role of Clonal hematopoiesis of indeterminate potential (CHIP) related gene mutations in atrial fibrillation (AF) and stroke in myeloproliferative neoplasm (MPN) patients, and explore the rol...
Macrophage Plg-RKT expression promotes diet-induced obesity and metabolic dysfunction-associated steatotic liver disease [0.03%]
巨噬细胞Plg-RKT表达促进饮食诱导的肥胖和与代谢功能异常相关的脂肪变性肝病
Lindsey A Miles,Hongdong Bai,Sagarika Chakrabarty et al.
Lindsey A Miles et al.
Background: Plg-RKT, is a transmembrane plasminogen receptor which enhances the activation of plasminogen to plasmin and localizes proteolytic activity of plasmin on the cell surface. We investigated the role of Plg-RKT i...
Effects of Physical Activity on Platelet Activation and Hemostasis During Pregnancy - are placento-exerkines the hidden drivers? [0.03%]
运动对妊娠期血小板活化和止血的影响-胎盘运动因子是背后的驱动因素吗？
Freya Lyssy,Martin Gauster,Désirée Forstner
Freya Lyssy
Pregnancy is characterized by a physiological shift toward a pro-thrombotic state, necessary to prevent postpartum hemorrhage but also contributing to the pathogenesis of placental disorders such as preeclampsia (PE) and fetal growth restri...
Adding contrast to shed some light - A case of acute thrombocytopenia due to iohexol-dependent antibodies to glycoprotein IIb/IIIa [0.03%]
加用对比剂致急性血小板减少症一例：iohexol依赖性抗糖蛋白IIb/IIIa抗体所致
Ingvild Jenssen Lægreid,Erin Mathiesen Hald,Mirjana Grujic Arsenovic et al.
Ingvild Jenssen Lægreid et al.
Thrombocytopenia due to iodine contrast media is a rare complication, only sporadically reported in the medical literature. The mechanism for thrombocytopenia is not known, but the platelet count dynamics in the reported cases suggest an im...
Antibody-mediated multicellular pathophysiology of HIT and VITT: the dynamic roles of platelets, neutrophils, endothelial cells, and monocytes [0.03%]
HIT和VITT的抗体介导的多细胞病理生理学：血小板、中性粒细胞、内皮细胞和单核细胞的动态作用
Romy T Meier,Rick Kapur
Romy T Meier
Heparin-induced thrombocytopenia (HIT) is a severe immune-mediated reaction to heparin, characterized by thrombocytopenia and an increased risk of thrombosis. Its pathophysiology is centered around the formation of antibodies directed again...
Preclinical safety and bleeding evaluation in swine for an siRNA-lipid nanoparticle that prevents excess fibrinogen synthesis [0.03%]
用于预防过多纤维蛋白原合成的siRNA-脂质纳米颗粒在猪身上的药代动力学评估，安全性和出血评价研究
Monica S Seadler,Francesca Ferraresso,Halen M Turner et al.
Monica S Seadler et al.
Background: Fibrinogen levels can drastically increase from inflammation, trauma, or surgery, which drives an increased risk of venous thromboembolism (VTE). We developed small interfering RNA (siFibrinogen) that decrease...
Standardization of scanning electron microscopy analysis of fibrin fiber diameter measurement: Communication from the ISTH SSC Subcommittee on FXIII and Fibrinogen [0.03%]
国际血栓与止血学会第十三因子和纤维蛋白原分会有关标准化扫描电镜测定纤维直径的通讯报告
Can Cai,Zelda De Lange-Loots,Stephen R Baker et al.
Can Cai et al.
Background: The microscopic fibrin clot structure, such as fibrin fiber length and diameter, network fiber density, and pore size, can be correlated with mechanical properties, permeability, susceptibility to lysis, and d...
Sex differences in outcomes of vitamin K antagonist treatment in patients with a mechanical heart valve: a Dutch population-based cohort study [0.03%]
维生素K拮抗剂治疗机械瓣膜患者的疗效性别差异：荷兰队列研究
Eva K Kempers,Chantal Visser,Jaap Seelig et al.
Eva K Kempers et al.
Background: Patients with a mechanical heart valve (MHV) require vitamin K antagonist (VKA) treatment to prevent thromboembolism. Objectives: ...