FOSL1 Orchestrates Epigenetic Reprogramming of Anaplastic Thyroid Cancer and Suppresses Natural Killer Cell-Mediated Antitumor Immunity [0.03%]
FOSL1通过表观遗传重塑调控分化型甲状腺癌发生及抑制自然杀伤细胞抗肿瘤免疫功能
Yanfei Huo,Yizhou Huang,Xinyuan Yu et al.
Yanfei Huo et al.
Anaplastic thyroid cancer (ATC) is the most aggressive type of thyroid cancer with survival time of only 7-10 months. Previous work revealed reduced proportions and cytotoxicity of natural killer (NK) cells in ATC tumor microenvironment (TM...
Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to KIF18A Inhibition [0.03%]
JAK1功能丧失导致G2/M细胞周期缺陷，易受KIF18A抑制的影响
Vanessa M Kelley,Marta Baro,William E Gasperi et al.
Vanessa M Kelley et al.
Therapeutic resistance to DNA damage is a significant challenge in oncology. To gain insight into biological mechanisms that cause DNA damage resistance and to inform strategies for achieving synergy with therapeutic radiation, we performed...
Targeting LRRC15 in Cancer-Associated Fibroblasts Modifies the Extracellular Matrix and Enhances Tumor Immune Responses to Suppress Lung Cancer Progression [0.03%]
靶向作用于癌相关成纤维细胞的LRRC15能改变细胞外基质并增强肿瘤免疫反应以抑制肺癌进展
Lu Qi,Guohui Dang,Xinnan Ling et al.
Lu Qi et al.
Cancer-associated fibroblasts (CAFs) play a crucial role in shaping the tumor microenvironment (TME) and driving tumor progression. While single-cell transcriptomics has revealed the phenotypic and functional heterogeneity of CAFs, effectiv...
Intratumoral P. copri Reprograms MARCO+ Tumor-Associated Macrophages by Depleting Glycerophosphocholine to Drive Colorectal Cancer Progression [0.03%]
瘤内P.copri通过耗竭甘油磷胆碱重新编程MARCO+肿瘤相关巨噬细胞以促进结直肠癌进展
Qihang Yuan,Yushan Sun,Yue Zhang et al.
Qihang Yuan et al.
Colorectal cancer (CRC) is characterized by a complex tumor microenvironment (TME) shaped by intestinal microbiota. In this study, 16S rRNA sequencing of CRC patient tissues identified Prevotella, particularly the dominant species Prevotell...
ACSL5 Mediates Adaptation to the Palmitic Acid-Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis [0.03%]
ACSL5介导适应富含棕榈酸的肺微环境以增强转移性乳腺癌细胞存活和肺转移
Shanchun Chen,Chao Chang,Xiaoqi Liu et al.
Shanchun Chen et al.
Solid tumors frequently preferentially metastasize to specific organs. Metabolites within metastatic niches have emerged as critical regulators of organotropic metastasis. Here, we found that palmitic acid (PA) accumulated in both pre- and ...
IDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma [0.03%]
IDH1通过诱导染色质重塑和DHODH转录来重新编程核苷酸代谢，以驱动鼻咽癌的化学抗性
Yuheng Zhao,Chunxian Ou,Huimin Huang et al.
Yuheng Zhao et al.
Metabolic reprogramming under therapeutic stress may represent a targetable vulnerability for cancer treatment. Elucidation of the metabolic alterations linked to chemotherapy in nasopharyngeal carcinoma (NPC) could uncover potential therap...
Intratumoral Lactobacillus johnsonii Enhances Sensitivity to PD-1 Blockade by Inducing CD8+ T Cell Expansion in Hepatocellular Carcinoma [0.03%]
瘤内乳酸菌通过诱导细胞扩张增强肝癌中PD-1阻断的敏感性
Qianshi Liu,Yiqiang Liu,Yue Zhou et al.
Qianshi Liu et al.
While surgical resection is an effective intervention for early-stage hepatocellular carcinoma (HCC), postoperative recurrence remains a major clinical hurdle. Delving into the mechanisms underlying relapse and pinpointing potential therape...
Cell and Nuclear Size are Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells that Undergo Whole Genome Doubling [0.03%]
癌细胞的全基因组加倍与细胞和核大小、染色体不稳定性和肿瘤发生之间的关系
Mathew Bloomfield,Sydney M Huth,Daniella S McCausland et al.
Mathew Bloomfield et al.
Whole genome doubling (WGD) is a frequent event in cancer evolution associated with chromosomal instability, metastasis, and poor prognosis. While the genomic consequences of WGD are well documented, non-genetic alterations that accompany W...
ETC-501 is a Brain Penetrant MNK Kinase Inhibitor that Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy [0.03%]
ETC-501是一种穿透大脑的MNK激酶抑制剂，可增强TMZ诱导的细胞衰老并使胶质母细胞瘤细胞对衰老清除疗法敏感
Giselle Sek Suan Nah,Yuk Kien Chong,Fatin Nasha Sulaimi et al.
Giselle Sek Suan Nah et al.
Glioblastoma (GBM) is the deadliest primary brain tumor in adults, with a median survival of only 15 months and fewer than 10% of patients surviving beyond 5 years. Despite aggressive multimodal therapies, including surgical resection, radi...
KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment [0.03%]
KRASG12R突变型胰腺癌具有有限的ERK / MAPK转录活性和独特的肿瘤微环境
Rachel A Burge,Ozgun Le Roux,Olesja Popow et al.
Rachel A Burge et al.
Patients with pancreatic ductal adenocarcinoma (PDAC) harboring KRASG12R mutations have increased overall survival relative to patients with KRASG12D/V mutations. To investigate the mechanisms underlying this differential outcome, we develo...