Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells [0.03%]
小胶质细胞对播散性肿瘤细胞的初始反应异质性强
Takahiro Tsuji,Haruka Hirose,Daisuke Sugiyama et al.
Takahiro Tsuji et al.
Brain metastases are frequent and often lethal complications of advanced cancers. Microglia, resident immune cells of the brain, are known to exert both anti-tumor and pro-tumor functions in late-stage metastases; however, their response du...
Macropinocytosis and Vascularization Determine Response to mTOR Inhibitors in Lung Squamous Cell Carcinoma [0.03%]
巨胞饮和血管生成决定mTOR抑制剂在肺鳞状细胞癌中的反应
Morgan R Brady,Nedas Matulionis,Heather R Christofk et al.
Morgan R Brady et al.
The capacity of cancer cells to rewire their cellular metabolism in response to therapeutic pressure confers resistance to treatments targeting key metabolic pathways, which represents a significant challenge in personalized cancer therapy ...
Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progression of Breast Cancer [0.03%]
肿瘤细胞与脂质相关巨噬细胞融合驱动乳腺癌转移进展
Yixin Cheng,Guanyin Huang,Xuefei Liu et al.
Yixin Cheng et al.
Intratumoral heterogeneity supports cancer progression and metastasis while limiting therapeutic efficacy. Comprehensive biological characterization of heterogeneous subclones in breast cancer may hold promise in battling against this deadl...
Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity [0.03%]
抗体介导的分泌蛋白SCUBE3靶向通过抑制致癌信号传导并诱导抗肿瘤免疫来抑制癌症进展
Deepika Singh,Benjamin C Onyeagucha,Daisy Medina et al.
Deepika Singh et al.
Approaches targeting factors that simultaneously promote tumor growth and progression, induce therapy resistance, and inhibit anti-tumor immunity offer clear benefits over therapies targeting only one of these tumor-promoting processes. Thr...
GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma [0.03%]
GFER代表胰腺癌中破坏氧化还原稳态和重新激活免疫反应的双重靶标
Ziheng Chen,I-Lin Ho,Jintan Liu et al.
Ziheng Chen et al.
Both metabolic dysregulation and the immunosuppressive tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) contribute to the recalcitrance of this lethal disease to treatment. Accordingly, we aimed to identify and characterize...
Transfer of Damaged Mitochondria from Cancer Cells to Cancer-Associated Fibroblasts Promotes Tyrosine Kinase Inhibitor Tolerance in EGFR-Mutant Lung Cancer [0.03%]
致癌细胞向癌相关成纤维细胞转移线粒体促进表皮生长因子受体突变型肺癌的酪氨酸激酶抑制耐药性
Tongyan Liu,Shiyi Huang,Zhitong Li et al.
Tongyan Liu et al.
Drug-tolerant persister (DTP) cells drive therapeutic resistance in EGFR-mutant lung adenocarcinoma. Using single-cell RNA sequencing, we identified a clinically significant RGS5+MYL9+ cancer-associated fibroblast (CAF) population that was ...
Integration of Short- and Long-Read RNA Sequencing Enables the Discovery of Circular RNAs [0.03%]
短长读RNA测序的结合能够发现环形RNA
Sidi Z Swift,Jace Webster,Hung Mai et al.
Sidi Z Swift et al.
Circular RNAs (circRNAs) are associated with crucial hallmarks of tumorigenesis. Select circRNAs contain circular open reading frames (cORFs) and impact tumorigenesis through encoded small peptides. However, current circRNA detection approa...
Fabio Zani,Julianna Blagih
Fabio Zani
Sugar-sweetened beverages (SSBs), which contain both glucose and fructose, have been linked to an increased incidence of colorectal cancer (CRC). Their effects on CRC progression, however, are unclear. In their recent work, Feng and colleag...
Can't KEEP Up: UXS1 Dependency Exposes a Pyrimidine Vulnerability in KEAP1-Mutant Lung Cancer [0.03%]
不能应对：UXS1依赖性揭示了KEAP1突变型肺癌中嘧啶的脆弱性
Basma A Yasseen,Gina M DeNicola
Basma A Yasseen
Loss-of-function mutations in KEAP1 are found in more than 20% of non-small cell lung cancers. These mutations stabilize the transcription factor NRF2 to induce a battery of antioxidative and cytoprotective genes. Although NRF2 accumulation...
Gut Check: Lactobacillus johnsonii Harnesses Bile Acids and Reactive Oxygen Species to Suppress High-Fat Diet-Induced Colorectal Cancer [0.03%]
胆汁酸和活性氧诱导调控肠道菌群预防高脂饮食诱发的结直肠癌发生发展的作用及机制研究
Prarthana J Dalal,Yatrik M Shah
Prarthana J Dalal
Colorectal cancer is among the most prevalent and deadly malignancies worldwide, with its incidence being closely associated with lifestyle factors, including high-fat diets (HFD). Epidemiologic studies correlate HFD with increased colorect...