Sara da Mata,Carlota Mora,Fernanda Silva et al.
Sara da Mata et al.
Endometrioid endometrial carcinoma (EEC) is the most common type of endometrial carcinoma. A small subset recurs exclusively in the vagina. Data on this group remain limited due to its low incidence and study heterogeneity, combining differ...
Untangling the Labyrinth: An Integrated View of the Mesothelial and Epithelial Linings of the Female Adnexa Based on Newly Characterized Anatomic and Histologic Junctions [0.03%]
解开迷宫：基于新发现的解剖和组织学连接对女性副性腺腔 mesothelial 和上皮衬里的综合观察
Jeffrey D Seidman,Russell Vang
Jeffrey D Seidman
Epithelial junctions such as the cervical transformation zone and the gastroesophageal and anorectal junctions are hotspots for carcinogenesis. Three junctional regions in the female adnexa have been recently described and characterized: th...
Vulvar Squamous Cell Carcinoma: Scientific Progress and Impacts to Pathology Practice [0.03%]
外阴鳞状细胞癌：科学研究进展及其对病理实践的影响
Lynn Hoang,Somayah Alsolami,Blake Gilks et al.
Lynn Hoang et al.
Despite vulvar cancer's rarity, meaningful advances have been made to improve the clinical care of affected patients-particularly with respect to vulvar squamous cell carcinoma (VSCC). These advances are reflected in changes to tumor classi...
Universal Molecular Testing for Endometrial Cancers: Institutional Experience and Focus on Phenotypic and Clinical Characterization of POLE-mutated Cases [0.03%]
子宫内膜癌的全基因检测：机构经验及POLE突变型病例表型和临床特征分析聚焦
Laura Warren,Courtney Connelly,Susan J Hsiao et al.
Laura Warren et al.
Molecular classification of endometrial tumors is now incorporated into the 2023 FIGO staging criteria. The POLE-mutated (POLEmut) subtype is reported to have a favorable prognosis despite aggressive morphologic features. Our institution be...
Stepwise Increase of Carboxypeptidase E and Altered ALDH1A1 Expression During Cervical Carcinogenesis: A Retrospective Immunohistochemical Study [0.03%]
宫颈癌变过程中羧肽酶E的逐步升高和ALDH1A1表达的改变：一项回顾性免疫组化研究
Tevfik Berk Bildaci,Selcuk Erkilinc,Ilker Cakir et al.
Tevfik Berk Bildaci et al.
Cervical carcinogenesis involves progressive molecular changes from preinvasive lesions to invasive carcinoma. Carboxypeptidase E (CPE) and aldehyde dehydrogenase 1A1 (ALDH1A1) have been implicated in cancer-related pathways, yet their stag...
HER2 and FOLR1 Expression in Mesonephric and Mesonephric-Like Adenocarcinomas in the Gynecologic Tract [0.03%]
妇科生殖道中肾腺癌和中肾类腺癌中的HER2和FOLR1表达
Eyas Alzayadneh,Megan E Dibbern,Joseph Rabban et al.
Eyas Alzayadneh et al.
Mesonephric adenocarcinoma (MA) of the cervix and mesonephric-like adenocarcinoma (MLA) of the endometrium and ovaries are rare, aggressive tumors showing limited response to standard therapy. The DESTINY-PanTumor02 study demonstrated stron...
Endometrial Endometrioid Carcinomas With Signet Ring Cells: Report of a Case Series With Detailed Clinical, Pathologic, and Molecular Analysis [0.03%]
带印戒细胞子宫内膜管状腺癌的临床病理研究及分子分析（报告14例）
Megan Ryan,Jennifer Taylor,Lauren McConnell et al.
Megan Ryan et al.
Signet ring cells are extremely rare in primary endometrial carcinomas with a limited number of reported cases. We report a series of 5 endometrioid-type endometrial carcinomas with signet ring cells, the largest reported series in the lite...
Illustrating the "Quiet Genome" Concept of SMARCA4-Deficient Uterine Sarcoma Via Whole-Exome Sequencing: A Highly Aggressive Case in a Young Woman [0.03%]
通过外显子组测序阐释SMARCA4缺陷型子宫肉瘤“安静基因组”概念：一例年轻女性高度侵袭性病例研究报告
Hiroshi Yoshida,Kouya Shiraishi,Taro Yamanaka et al.
Hiroshi Yoshida et al.
SMARCA4-deficient undifferentiated uterine sarcoma (SDUS) is a rare, highly aggressive SWI/SNF-deficient malignancy that can morphologically overlap with undifferentiated endometrial carcinoma (UDEC). Although prior targeted sequencing stud...
Diagnostic Proficiency of Large Language Models in the Interpretation of Cervical Cytopathology [0.03%]
大型语言模型在宫颈细胞病理学诊断中的熟练度评估
Iason Psilopatis,Kleio Vrettou
Iason Psilopatis
To evaluate the diagnostic proficiency of well-established multimodal Large Language Models (LLMs)-specifically Gemini, Claude, and Copilot-in interpreting cervical cytopathology (PAP smears). This diagnostic accuracy study used 30 represen...
Primary Ovarian Pleomorphic Adenoma of Salivary Gland Type: Report of A Unique Case With A HMGA2::WIF1 Fusion [0.03%]
唾液腺型原发卵巢多形性腺瘤一例并伴有HMGA2::WIF1融合基因
Holly Beckett,Roger Hunt,W Glenn McCluggage
Holly Beckett
We report a unique case of a primary ovarian neoplasm with morphological and immunohistochemical features identical to a pleomorphic salivary adenoma in a 56-year-old female. Morphologically the tumour was composed of cellular nodules of bl...