Exercise as a Therapy to Maintain Telomere Function and Prevent Cellular Senescence [0.03%]
运动作为维持端粒功能和预防细胞衰老的疗法
Jeongjin J Kim,Alexander Ahn,Jeffrey Ying et al.
Jeongjin J Kim et al.
Exercise transiently impacts the expression, regulation, and activity of TERT/telomerase to maintain telomeres and protect the genome from insults. By protecting the telomeres (chromosome ends) and the genome, telomerase promotes cellular s...
Exercise Mediates Myokine Release and Tumor Suppression in Prostate Cancer Independent of Androgen Signaling [0.03%]
运动介导肌细胞因子释放和前列腺癌中的肿瘤抑制作用独立于雄激素信号转导
Jin-Soo Kim,Dennis R Taaffe,Daniel A Galvão et al.
Jin-Soo Kim et al.
A prominent toxicity of androgen suppression in patients with prostate cancer (PCa) is loss of skeletal muscle. Exercise may induce tumor suppression through the endocrinal function of skeletal muscle; however, this is currently unknown. In...
Biomechanical Tradeoffs in Foot Function From Variations in Shoe Design [0.03%]
鞋类设计差异对步态生物力学的影响及其功能利弊分析
Ali Yawar,Daniel E Lieberman
Ali Yawar
There is debate and confusion over how to evaluate the biomechanical effects of running shoe design. Here, we use an evolutionary perspective to analyze how key design features of running shoes alter the evolved biomechanics of the foot, cr...
Affective Response During Real-World Physical Activity as an Intervention Mediator [0.03%]
真实世界身体活动的情感反应作为干预调解因素
Genevieve F Dunton,Rachel Crosley-Lyons,Ryan E Rhodes
Genevieve F Dunton
Some people experience pleasure during physical activity, whereas it can be unpleasant for others. Modifying affective responses during physical activity in real-world situations may be an intervention strategy for increasing physical activ...
Eccentric Exercise as a Potent Prescription for Muscle Weakness After Joint Injury [0.03%]
关节损伤后离心运动能够有效改善肌肉无力状况
Lindsey K Lepley,Luke Stoneback,Peter C D Macpherson et al.
Lindsey K Lepley et al.
Lengthening contractions (i.e., eccentric contractions) are capable of uniquely triggering the nervous system and signaling pathways to promote tissue health/growth. This mode of exercise may be particularly potent for patients suffering fr...
Jacob B Harth,Lisa M Renzi-Hammond,Billy R Hammond Jr
Jacob B Harth
Visual range is quantified by assessing how far one can see clearly (an ability crucial to many athletes). This ability tends to vary significantly across individuals despite similar personal characteristics. We hypothesize that the primary...
Energizing Mitochondria to Prevent Mobility Loss in Aging: Rationale and Hypotheses [0.03%]
激活线粒体以防止衰老引起的活动能力下降：原理和假设
Qu Tian,Philip R Lee,Keenan A Walker et al.
Qu Tian et al.
Based on recent studies from our group and others, we hypothesize that mitochondrial dysfunction during aging may be the root cause of mobility decline through deficits in the musculoskeletal and central nervous systems. Mitochondrial dysfu...
Sex Differences in Athletic Performance: Perspectives on Transgender Athletes [0.03%]
论运动员比赛表现的性别差异：关于跨性别运动员的思考
Natalie J Nokoff,Jonathon Senefeld,Csilla Krausz et al.
Natalie J Nokoff et al.
Sex hormone concentrations, particularly testosterone, are primary determinants of sex-based differences in athletic and sports performance, and this relationship may inform fair competition and participation for athletes. This article desc...
Milena Samora,Ann-Katrin Grotle,Audrey J Stone
Milena Samora
Exaggerated cardiovascular responses to exercise increase the risk of myocardial infarction and stroke in individuals with type 1 diabetes (T1D); however, the underlying mechanisms remain largely elusive. This review provides an overview of...
William A Fountain,Masatoshi Naruse,Alex Claiborne et al.
William A Fountain et al.
Chronic inflammation is associated with a decline in aging skeletal muscle health. Inflammation also seems to interfere with the beneficial skeletal muscle adaptations conferred by exercise training in older individuals. We hypothesize that...