Augmenting β2-adrenergic signaling during exercise to enhance anti-tumor immune function [0.03%]
运动时增强β2肾上腺素能信号传导可提高抗肿瘤免疫功能
Timothy M Kistner,Emmanuel Katsanis,Richard J Simpson
Timothy M Kistner
Exercise is emerging as a powerful adjuvant therapy during cancer treatment, partly due to its immunomodulatory effects. However, the moderate to vigorous intensities required for optimal immune-boosting effects are a barrier for many patie...
Lyndsey E DuBose,Kerrie L Moreau
Lyndsey E DuBose
Limb Disuse Trials in Humans: Key Insights on Study Design, Ethics, and Project Execution [0.03%]
人体 limbs 不使用试验的设计、伦理及项目实施要点剖析——从关键研究中获得的见解
Matt S Stock,Kylie K Harmon,Justin W Andrushko et al.
Matt S Stock et al.
Limb disuse models, such as immobilization and limb suspension, have been implemented for 30+ years to understand the mechanistic and clinical implications of neuromuscular impairments and muscle atrophy. Drawing on decades of experience, w...
David E Conroy
David E Conroy
Seasonal phase variation, characterized as a sinusoidal waveform anchored at the annual solstices, can be positively associated with both between- and within-person differences in physical activity in observational, longitudinal, and experi...
microRNA-1: A Master Regulator of Metabolism Governing Skeletal Muscle Hypertrophy [0.03%]
微小核糖核酸-1：调控代谢的主调节因子，在骨骼肌肥大中的作用
Jainil Daredia,Benjamin I Burke,John J McCarthy et al.
Jainil Daredia et al.
Downregulation of microRNA-1 (miR-1), the most abundant muscle-enriched microRNA, represents a conserved hallmark of skeletal muscle hypertrophy across species. We propose that mechanical overload-induced reduction in miR-1 expression drive...
Soichi Ando,Toshihiko Fujimoto,Mizuki Sudo et al.
Soichi Ando et al.
Acute physical exercise improves cognitive performance; however, the underlying physiological mechanisms are not yet fully understood. Here, we propose that enhanced neuromodulation is a crucial factor in the exercise-cognition interaction ...
Cognitive neuro-electrical activity during preparation for exercise under hyperthermia [0.03%]
高温环境下运动准备状态的脑电活动及认知效应研究
Manabu Shibasaki,Hiroki Nakata
Manabu Shibasaki
Exercise in a hot environment can impair performance due to not only impaired coordination of major physiological systems but also reduced cognitive processing related to the exercise strategy. In this review, we discuss potential factors c...
Breaking Boundaries Between Resistance and Aerobic Training in Cancer Survivors [0.03%]
癌症幸存者抗阻训练和有氧运动界限的突破
Kyuwan Lee
Kyuwan Lee
Current exercise guidelines for cancer survivors continue to rely on a binary separation of resistance and aerobic training. This review proposes a stimulus-based continuum, in which mechanical load, cardiorespiratory strain, metabolic stre...
Reactive Hyperemia: revisiting a key vascular feature of cardiorespiratory fitness [0.03%]
反应性充血：重新审视心血管健康的关键血管特征
Nicholas Blackmond,Juan M Murias,Rogerio Nogueira Soares
Nicholas Blackmond
Although flow-mediated dilation (FMD) is a well-established marker of conduit artery endothelial function, it is not optimally suited to detect endurance exercise training-mediated vascular adaptations in healthy individuals. Herein, we eva...
Sex Over Cycle: Sex Differences Outweigh Menstrual Cycle Effects on Human Motor Output [0.03%]
性别差异超过月经周期对人类运动输出的影响
Sophia T Jenz,Gregory E P Pearcey
Sophia T Jenz
Females are underrepresented in research often due to concerns about potential variability introduced by the menstrual cycle. Although the cycle influences motor output, these effects are small and inconsistent, and are rarely interpreted r...