Heat shock proteins are important mediators of skeletal muscle insulin sensitivity [0.03%]
热休克蛋白是骨骼肌胰岛素敏感性的重要调节因子
Paige C Geiger,Anisha A Gupte
Paige C Geiger
Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic character...
Aging, persistent viral infections, and immunosenescence: can exercise "make space"? [0.03%]
衰老、持续性病毒感染和免疫衰老：运动能“开拓空间”吗？
Richard J Simpson
Richard J Simpson
Overcrowding the immune space with excess clones of viral-specific T cells causes the naïve T-cell repertoire to shrink, which increases infection susceptibility to novel pathogens. Physical exercise preferentially mobilizes senescent T ce...
Biomechanics of sport concussion: quest for the elusive injury threshold [0.03%]
运动生物力学与脑震荡伤：寻找难以捉摸的损伤阈值
Kevin M Guskiewicz,Jason P Mihalik
Kevin M Guskiewicz
Previous concussion biomechanics research has relied heavily on the animal model or laboratory reconstruction of concussive injuries captured on video footage. Real-time data collection involves a novel approach to better understanding the ...
Mark W Hamrick
Mark W Hamrick
This review presents the hypothesis that muscle is a source of secreted factors (myokines) that can influence bone mass in both positive and negative ways. Growth factor secretion by muscle may therefore be one pathway through which mechani...
Control of human limb movements: the leading joint hypothesis and its practical applications [0.03%]
人类肢体运动控制：主导关节假说及其应用研究进展
Natalia Dounskaia
Natalia Dounskaia
The leading joint hypothesis (LJH) offers a novel interpretation of control of human movements that involve multiple joints. The LJH makes control of each multijoint movement transparent. This review highlights effective applications of the...
Complex integrative morphological and mechanical contributions to ACL injury risk [0.03%]
复杂而综合的形态和力学因素对前交叉韧带损伤易感性的影响
Scott G McLean,Mélanie L Beaulieu
Scott G McLean
By failing to consider the integrative impact of key morphological and neuromechanical factors within the anterior cruciate ligament injury mechanism, we consider the current injury prevention model to be flawed. Critical links between thes...
Robert W Motl
Robert W Motl
Multiple sclerosis (MS) is a neurological disease that may result in the progressive worsening of disability. Recent research has identified physical activity as a behavioral correlate of disability in MS. The current review highlights that...
D Walter Wray,Steve K Nishiyama,Anthony J Donato et al.
D Walter Wray et al.
Unlike quadrupeds, human limbs are exposed to differing homeostatic challenges and uses across the life span. This raises the question of whether vascular function and skeletal muscle blood flow regulation differs between human limbs and wh...
James A Carson,Kristen A Baltgalvis
James A Carson
Interleukin 6 (IL-6) has received significant attention for its regulatory role in muscle wasting during cachexia. This review examines the role of circulating IL-6 for decreasing muscle mass during cancer and emphasizes some of the indirec...
Does careful glycemic control improve aerobic capacity in subjects with type 1 diabetes? [0.03%]
严格血糖控制可以改善1型糖尿病患者的有氧运动能力吗？
James C Baldi,Paul L Hofman
James C Baldi
Existing evidence shows that some, but not all, individuals with type 1 diabetes are capable of the same aerobic capacity as matched nondiabetic subjects. Poor glycemic control impairs pulmonary, cardiac, and vascular responses to exercise....